Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation.  They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Found 341 Results
Title Research Area Disease Model System/Component Year
The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology Molecular Biology and Pharmacology Development
 615A: Dynamic Muscle Control and Analysis Software 2022
Minocycline Treatment Reduces Mass and Force Output From Fast-Twitch Mouse Muscles and Inhibits Myosin Production in C2C12 Myotubes Neuromuscular Atrophy
 615A: Dynamic Muscle Control and Analysis Software 2021
Effects of hindlimb suspension and reloading on gastrocnemius and soleus muscle mass and function in geriatric mice Muscle Pathology & Wasting Aging
 615A: Dynamic Muscle Control and Analysis Software 2019
Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy Muscle Pathology & Wasting Dystrophy
 800A/805A: in-vitro Muscle Apparatus 2021
On a coupled electro-chemomechanical model of gastric smooth muscle contraction General Physiology N/A
 800A/805A: in-vitro Muscle Apparatus 2020
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure Muscle Pathology & Wasting Cardiovascular
 615A: Dynamic Muscle Control and Analysis Software 2019
Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice Exercise & Metabolism Diabetes
 800A/805A: in-vitro Muscle Apparatus 2019
Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit Muscle Pathology & Wasting Dystrophy
 800A/805A: in-vitro Muscle Apparatus 2018
Exercise promotes satellite cell contribution to myofibers in a load-dependent manner Exercise & Metabolism N/A
 800A/805A: in-vitro Muscle Apparatus 2020
Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility Exercise & Metabolism Myopathy
 800A/805A: in-vitro Muscle Apparatus 2019
Shortening the thick filament by partial deletion of titin’s C-zone alters cardiac function by reducing the operating sarcomere length range Cardiology N/A
 2022
A high-whey-protein diet does not enhance mechanical and structural remodeling of cardiac muscle in response to aerobic exercise in rats Cardiology N/A
 2022
Contributions of Titin and Collagen to Passive Stress in Muscles from mdm Mice with a Small Deletion in Titin’s Molecular Spring Muscle Pathology & Wasting Dystrophy
 2022
One-to-one innervation of vocal muscles allows precise control of birdsong General Physiology N/A
 2021
FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy Muscle Pathology & Wasting Dystrophy
 2021
Passive force and viscoelastic properties of single fibers in human aging muscles General Physiology Aging
 2019
SIRT1 regulates nuclear number and domain size in skeletal muscle fibers Molecular Biology and Pharmacology N/A
 2018
Influence of residual force enhancement and elongation of attached cross-bridges on stretch-shortening cycle in skinned muscle fibers General Physiology N/A
 2017
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions Pain/Touch Diabetes
 300C-I: Dual-Mode Indenters 2021
Cortical Responses to Touch Reflect Subcortical Integration of LTMR Signals Pain/Touch N/A
 300C-I: Dual-Mode Indenters 2021
Intermittent Failure of Spike Propagation in Primary Afferent Neurons during Tactile Stimulation Pain/Touch N/A
 300C-I: Dual-Mode Indenters 2019
The signaling lipid sphingosine 1-phosphate regulates mechanical pain Pain/Touch N/A
 300C-I: Dual-Mode Indenters 2018
Influence of weighted downhill running training on serial sarcomere number and work loop performance in the rat soleus Exercise & Metabolism N/A
 615A: Dynamic Muscle Control and Analysis Software 2022
Influence of external forces on actin-dependent T cell protrusions during immune synapse formation Artificial Muscle Physiological Tissue N/A
 400B: Force Transducers 2021
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans Pain/Touch N/A
 300C-I: Dual-Mode Indenters 2021
Paraspinal Muscle Contractile Function is Impaired in the ENT1-deficient Mouse Model of Progressive Spine Pathology Neuromuscular Neurodegenerative
 901D: High-Speed Video Sarcomere Length 2021
Efficient precise in vivo base editing in adultdystrophic mice Muscle Pathology & Wasting DMD
 1300A: 3-in-1 Whole Animal System for Mice 2021
Store-Operated Ca2+ Entry in Skeletal Muscle Contributes to the Increase in Body Temperature during Exertional Stress Exercise & Metabolism N/A
 1200A: Isolated Muscle System for Mice 2022
High-Fat Diet Impairs Muscle Function and Increases the Risk of Environmental Heatstroke in Mice Exercise & Metabolism N/A
 1200A: Isolated Muscle System for Mice 2022
microRNA‐29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery Molecular Biology and Pharmacology Ischmia/Reperfusion
 1300A: 3-in-1 Whole Animal System for Mice 2022
Influenza A Virus-Driven Airway Inflammation may be Dissociated From Limb Muscle Atrophy in Cigarette Smoke-Exposed Mice Muscle Pathology & Wasting Atrophy
 1300A: 3-in-1 Whole Animal System for Mice 2022
Muscle mitochondrial remodeling by intermittent glucocorticoid drugs requires an intact circadian clock and muscle PGC1α Exercise & Metabolism Dystrophy
 1300A: 3-in-1 Whole Animal System for Mice 2022
Silencing of the Ca2+ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice Muscle Pathology & Wasting Myopathy
 1305A: 3-in-1 Whole Animal System for Rats 2022
Reduced cardiac muscle power with low ATP simulating heart failure Cardiology Cardiovascular
 1400A: Permeabilized Fiber System – Microscope Mountable 2022
Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging Muscle Pathology & Wasting Aging
 1400A: Permeabilized Fiber System – Microscope Mountable 2022
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy Muscle Pathology & Wasting Myopathy
 1500A: Isolated Muscle System – Microscope Mountable 2022
Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy Cardiology Cardiovascular
 1500A: Isolated Muscle System – Microscope Mountable 2022
Novel γ-sarcoglycan interactors in murine muscle membranes Molecular Biology and Pharmacology Dystrophy
 800A/805A: in-vitro Muscle Apparatus 2022
The road not taken: Evolution of tetrodotoxin resistance in the Sierra garter snake (Thamnophis couchii) by a path less traveled General Physiology N/A
 800A/805A: in-vitro Muscle Apparatus 2022
Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression Muscle Pathology & Wasting DMD
 1300A: 3-in-1 Whole Animal System for Mice 2021
In vivo Measurement of Knee Extensor Muscle Function in Mice Orthopedics Injury
 1300A: 3-in-1 Whole Animal System for Mice 2021
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline Muscle Pathology & Wasting Aging
 1305A: 3-in-1 Whole Animal System for Rats 2021
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics Cardiology Cardiovascular
 1500A: Isolated Muscle System – Microscope Mountable 2021
Impact of syndecan-2-selected mesenchymal stromal cells on the early onset of diabetic cardiomyopathy in diabetic db/db mice Cardiology Diabetes
 1600A: Permeabilized Myocyte System – Microscope Mountable 2021
Representational drift in primary olfactory cortex Olfaction Odor Perception
 200B: miniPID Fast Response Olfaction Sensor 2021
Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein Orthopedics Musculoskeletal
 300C: Dual-Mode Muscle Levers 2021
Pharmacological Mitigation of Fibrosis in a Porcine Model of Volumetric Muscle Loss Injury General Physiology Volumetric Muscle Loss
 890A: in-situ Large Animal Apparatus 2020
Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression Muscle Pathology & Wasting DMD
 1300A: 3-in-1 Whole Animal System for Mice 2021
In vivo Measurement of Knee Extensor Muscle Function in Mice Orthopedics Injury
 1300A: 3-in-1 Whole Animal System for Mice 2021
Optogenetic activation of muscle contraction in vivo Neuromuscular N/A
 1300A: 3-in-1 Whole Animal System for Mice 2021
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline Muscle Pathology & Wasting Aging
 1305A: 3-in-1 Whole Animal System for Rats 2021
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics Cardiology Cardiovascular
 1500A: Isolated Muscle System – Microscope Mountable 2021
Impact of syndecan-2-selected mesenchymal stromal cells on the early onset of diabetic cardiomyopathy in diabetic db/db mice Cardiology Diabetes
 1600A: Permeabilized Myocyte System – Microscope Mountable 2021
Representational drift in primary olfactory cortex Olfaction Odor Perception
 200B: miniPID Fast Response Olfaction Sensor 2021
Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein Orthopedics Musculoskeletal
 300C: Dual-Mode Muscle Levers 2021
Influence of external forces on actin-dependent T cell protrusions during immune synapse formation Artificial Muscle Physiological Tissue N/A
 400B: Force Transducers 2021
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans Pain/Touch N/A
 300C-I: Dual-Mode Indenters 2021
Paraspinal Muscle Contractile Function is Impaired in the ENT1-deficient Mouse Model of Progressive Spine Pathology Neuromuscular Neurodegenerative
 901D: High-Speed Video Sarcomere Length 2021
Efficient precise in vivo base editing in adultdystrophic mice Muscle Pathology & Wasting DMD
 1300A: 3-in-1 Whole Animal System for Mice 2021
Dose-Escalation Study of Systemically Delivered rAAVrh74.MHCK7.micro-dystrophin in the mdx Mouse Model of Duchenne Muscular Dystrophy Muscle Pathology & Wasting DMD
 1305A: 3-in-1 Whole Animal System for Rats 2021
A novel ex vivo protocol to mimic human walking gait: implications for Duchenne muscular dystrophy Muscle Pathology & Wasting DMD
 1300A: 3-in-1 Whole Animal System for Mice 2020
Muscle contraction induces osteogenic levels of cortical bone strain despite muscle weakness in a mouse model of Osteogenesis Imperfecta Orthopedics Musculoskeletal
 1300A: 3-in-1 Whole Animal System for Mice 2020
Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction Exercise & Metabolism Obesity
 1500A: Isolated Muscle System – Microscope Mountable 2020
In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes Cardiology Cardiovascular
 1600A: Permeabilized Myocyte System – Microscope Mountable 2020
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues General Physiology Myopathy
 1600A: Permeabilized Myocyte System – Microscope Mountable 2020
Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator Cardiology Cardiovascular
 1600A: Permeabilized Myocyte System – Microscope Mountable 2020
Quantitative assessment of olfactory dysfunction accurately detects asymptomatic COVID-19 carriers Olfaction COVID-19
 200B: miniPID Fast Response Olfaction Sensor 2020
The contribution of temporal coding to odor coding and odor perception in humans Olfaction Odor Perception
 200B: miniPID Fast Response Olfaction Sensor 2020
In vitro virtual reality: an anatomically explicit musculoskeletal simulation powered by in vitro muscle using closed-loop tissue–software interaction General Physiology N/A
 300C: Dual-Mode Muscle Levers 2020
Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice Orthopedics Musculoskeletal
 300C: Dual-Mode Muscle Levers 2020
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals Muscle Pathology & Wasting Atrophy
 300C: Dual-Mode Muscle Levers 2020
Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception Pain/Touch N/A
 300C-I: Dual-Mode Indenters 2020
Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function Biomaterials Polymers Volumetric Muscle Loss
 2020
Mechanical Properties of Single Muscle Fibers: Understanding Poor Muscle Quality in Older Adults with Diabetes Muscle Pathology & Wasting Diabetes
 315D/322D: High-Speed Length Controllers 2020
Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation Artificial Muscle Physiological Tissue N/A
 400B: Force Transducers 2020
Improved volatile cargo retention and mechanical properties of capsules via sediment-free in situ polymerization with cross-linked poly(vinyl alcohol) as an emulsifier Nanomaterials MEMS N/A
 400B: Force Transducers 2020
Motor transmission defects with sex differences in a new mouse model of mild spinal muscular atrophy Neuromuscular Neurodegenerative
 400B: Force Transducers 2020
Long-Term Evaluation of Functional Outcomes Following Rat Volumetric Muscle Loss Injury and Repair Biomaterials Polymers Volumetric Muscle Loss
 1305A: 3-in-1 Whole Animal System for Rats 2020
Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts Cardiology Cardiovascular
 801C: Small Intact Muscle Apparatus – Microscope Mountable 2020
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues Cardiology Cardiovascular
 801C: Small Intact Muscle Apparatus – Microscope Mountable 2020
Encoding of Wind Direction by Central Neurons in Drosophila Pheromone/Plume Tracking Odor Perception
 200B: miniPID Fast Response Olfaction Sensor 2019
Olfactory and Neuromodulatory Signals Reverse Visual Object Avoidance to Approach in Drosophila Olfaction, Pheromone/Plume Tracking Odor Perception
 200B: miniPID Fast Response Olfaction Sensor 2019
Mesoscopic and microscopic imaging of sensory responses in the same animal Olfaction Odor Perception
 200B: miniPID Fast Response Olfaction Sensor 2019
Long-Stroke Rolling Diaphragm Actuators For Haptic Display of Forces in Teleoperation Biomaterials Polymers N/A
 300C: Dual-Mode Muscle Levers 2019
Extracellular matrix stiffness regulates human airway smooth muscle contraction by altering the cell-cell coupling General Physiology Asthma
 300C: Dual-Mode Muscle Levers 2019
Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice Neuromuscular Neurodegenerative
 300C: Dual-Mode Muscle Levers 2019
Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice Pain/Touch Neurodegenerative
 300C-I: Dual-Mode Indenters 2019
Depiction of Oral Tumor-Induced Trigeminal Afferent Responses Using Single-Fiber Electrophysiology Pain/Touch Cancer
 300C-I: Dual-Mode Indenters 2019
Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease Neuromuscular Neurodegenerative
 2019
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure Muscle Pathology & Wasting Cardiovascular
 615A: Dynamic Muscle Control and Analysis Software 2019
Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease Neuromuscular Neurodegenerative
 701C: Electrical Stimulator 2019
Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasis Exercise & Metabolism Obesity
 701C: Electrical Stimulator 2019
Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice Exercise & Metabolism Diabetes
 800A/805A: in-vitro Muscle Apparatus 2019
Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity Exercise & Metabolism Atrophy
 801C: Small Intact Muscle Apparatus – Microscope Mountable 2019