Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation.  They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Found 371 Results
Title Research Area Disease Model System/Component Year
Explosive sensing with insect-based biorobots Pheromone/Plume Tracking Odor Perception
200B: miniPID Fast Response Olfaction Sensor 2020
Harnessing insect olfactory neural circuits for detecting and discriminating human cancers Pheromone/Plume Tracking Odor Perception
220A: Olfactometer 2023
Odor-searching Robot with Insect-behavior-based Olfactory Sensor Pheromone/Plume Tracking Odor Perception
200B: miniPID Fast Response Olfaction Sensor 2021
Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress Muscle Pathology & Wasting Cachexia
1300A: 3-in-1 Whole Animal System for Mice 2022
MYTHO is a novel regulator of skeletal muscle autophagy and integrity Muscle Pathology & Wasting Atrophy
1300A: 3-in-1 Whole Animal System for Mice 2023
Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth Muscle Pathology & Wasting Cancer
1200A: Isolated Muscle System for Mice 2023
Microdystrophin Gene Addition Significantly Improves Muscle Functionality and Diaphragm Muscle Histopathology in a Fibrotic Mouse Model of Duchenne Muscular Dystrophy Muscle Pathology & Wasting DMD
1300A: 3-in-1 Whole Animal System for Mice 2023
Anti-RANKL Therapy Prevents Glucocorticoid-Induced Bone Loss and Promotes Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy Molecular Biology and Pharmacology DMD
1200A: Isolated Muscle System for Mice 2023
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy Molecular Biology and Pharmacology DMD
1400A: Permeabilized Fiber System – Microscope Mountable 2023
Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues Artificial Muscle Physiological Tissue Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2023
Bioengineered 3D Skeletal Muscle Model Reveals Complement 4b as a Cell-Autonomous Mechanism of Impaired Regeneration with Aging Artificial Muscle Physiological Tissue Aging
1500A: Isolated Muscle System – Microscope Mountable 2023
Properties of Nav1.8ChR2-positive and Nav1.8ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice Pain/Touch Allodynia/Hyperalgesia
300C-I: Dual-Mode Indenters 2023
Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9 Neuromuscular Musculoskeletal
1200A: Isolated Muscle System for Mice 2023
The cellular basis of mechanosensation in mammalian tongue Pain/Touch N/A
300C-I: Dual-Mode Indenters 2023
Combinatorial encoding of odors in the mosquito antennal lobe Olfaction N/A
200B: miniPID Fast Response Olfaction Sensor 2023
Biodegradable electrohydraulic actuators for sustainable soft robots Materials Science N/A
300C: Dual-Mode Muscle Levers 2023
Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin Exercise & Metabolism Obesity
1300A: 3-in-1 Whole Animal System for Mice 2022
γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons Pain/Touch N/A
300C-I: Dual-Mode Indenters 2023
BAG3 Attenuates Ischemia-Induced Skeletal Muscle Necroptosis in Diabetic Experimental Peripheral Artery Disease Molecular Biology and Pharmacology Diabetes
1300A: 3-in-1 Whole Animal System for Mice 2022
Optimization and construct validity of approaches to preclinical grip strength testing Muscle Pathology & Wasting Aging
1300A: 3-in-1 Whole Animal System for Mice 2023
Constitutive assembly of Ca2+ entry units in soleus muscle from calsequestrin knockout mice General Physiology Musculoskeletal
1200A: Isolated Muscle System for Mice 2022
Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis Neuromuscular Neurodegenerative
1200A: Isolated Muscle System for Mice 2023
Ultrastructural and kinetic evidence support that thick filaments slide through the Z-disc General Physiology N/A
1400A: Permeabilized Fiber System – Microscope Mountable 2022
Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2022
Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2023
Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes Cardiology N/A
1400A: Permeabilized Fiber System – Microscope Mountable 2023
Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS Molecular Biology and Pharmacology Myopathy
1300A: 3-in-1 Whole Animal System for Mice 2023
ERRg agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation Artificial Muscle Physiological Tissue Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2023
Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia Artificial Muscle Physiological Tissue Ischmia/Reperfusion
2023
Meningeal P2X7 Signaling Mediates Migraine-Related Intracranial Mechanical Hypersensitivity Pain/Touch Migraine
2023
The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology Molecular Biology and Pharmacology Development
615A: Dynamic Muscle Control and Analysis Software 2022
Minocycline Treatment Reduces Mass and Force Output From Fast-Twitch Mouse Muscles and Inhibits Myosin Production in C2C12 Myotubes Neuromuscular Atrophy
615A: Dynamic Muscle Control and Analysis Software 2021
Effects of hindlimb suspension and reloading on gastrocnemius and soleus muscle mass and function in geriatric mice Muscle Pathology & Wasting Aging
615A: Dynamic Muscle Control and Analysis Software 2019
Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy Muscle Pathology & Wasting Dystrophy
800A/805A: in-vitro Muscle Apparatus 2021
On a coupled electro-chemomechanical model of gastric smooth muscle contraction General Physiology N/A
800A/805A: in-vitro Muscle Apparatus 2020
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure Muscle Pathology & Wasting Cardiovascular
615A: Dynamic Muscle Control and Analysis Software 2019
Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice Exercise & Metabolism Diabetes
800A/805A: in-vitro Muscle Apparatus 2019
Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit Muscle Pathology & Wasting Dystrophy
800A/805A: in-vitro Muscle Apparatus 2018
Exercise promotes satellite cell contribution to myofibers in a load-dependent manner Exercise & Metabolism N/A
800A/805A: in-vitro Muscle Apparatus 2020
Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility Exercise & Metabolism Myopathy
800A/805A: in-vitro Muscle Apparatus 2019
Shortening the thick filament by partial deletion of titin’s C-zone alters cardiac function by reducing the operating sarcomere length range Cardiology N/A
2022
A high-whey-protein diet does not enhance mechanical and structural remodeling of cardiac muscle in response to aerobic exercise in rats Cardiology N/A
2022
Contributions of Titin and Collagen to Passive Stress in Muscles from mdm Mice with a Small Deletion in Titin’s Molecular Spring Muscle Pathology & Wasting Dystrophy
2022
One-to-one innervation of vocal muscles allows precise control of birdsong General Physiology N/A
2021
FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy Muscle Pathology & Wasting Dystrophy
2021
Passive force and viscoelastic properties of single fibers in human aging muscles General Physiology Aging
2019
SIRT1 regulates nuclear number and domain size in skeletal muscle fibers Molecular Biology and Pharmacology N/A
2018
Influence of residual force enhancement and elongation of attached cross-bridges on stretch-shortening cycle in skinned muscle fibers General Physiology N/A
2017
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions Pain/Touch Diabetes
300C-I: Dual-Mode Indenters 2021
Cortical Responses to Touch Reflect Subcortical Integration of LTMR Signals Pain/Touch N/A
300C-I: Dual-Mode Indenters 2021
Intermittent Failure of Spike Propagation in Primary Afferent Neurons during Tactile Stimulation Pain/Touch N/A
300C-I: Dual-Mode Indenters 2019
The signaling lipid sphingosine 1-phosphate regulates mechanical pain Pain/Touch N/A
300C-I: Dual-Mode Indenters 2018
Influence of weighted downhill running training on serial sarcomere number and work loop performance in the rat soleus Exercise & Metabolism N/A
615A: Dynamic Muscle Control and Analysis Software 2022
Influence of external forces on actin-dependent T cell protrusions during immune synapse formation Artificial Muscle Physiological Tissue N/A
400B: Force Transducers 2021
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans Pain/Touch N/A
300C-I: Dual-Mode Indenters 2021
Paraspinal Muscle Contractile Function is Impaired in the ENT1-deficient Mouse Model of Progressive Spine Pathology Neuromuscular Neurodegenerative
901D: High-Speed Video Sarcomere Length 2021
Efficient precise in vivo base editing in adultdystrophic mice Muscle Pathology & Wasting DMD
2021
Store-Operated Ca2+ Entry in Skeletal Muscle Contributes to the Increase in Body Temperature during Exertional Stress Exercise & Metabolism N/A
1200A: Isolated Muscle System for Mice 2022
High-Fat Diet Impairs Muscle Function and Increases the Risk of Environmental Heatstroke in Mice Exercise & Metabolism N/A
1200A: Isolated Muscle System for Mice 2022
microRNA‐29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery Molecular Biology and Pharmacology Ischmia/Reperfusion
1300A: 3-in-1 Whole Animal System for Mice 2022
Influenza A Virus-Driven Airway Inflammation may be Dissociated From Limb Muscle Atrophy in Cigarette Smoke-Exposed Mice Muscle Pathology & Wasting Atrophy
1300A: 3-in-1 Whole Animal System for Mice 2022
Muscle mitochondrial remodeling by intermittent glucocorticoid drugs requires an intact circadian clock and muscle PGC1α Exercise & Metabolism Dystrophy
1300A: 3-in-1 Whole Animal System for Mice 2022
Silencing of the Ca2+ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice Muscle Pathology & Wasting Myopathy
1305A: 3-in-1 Whole Animal System for Rats 2022
Reduced cardiac muscle power with low ATP simulating heart failure Cardiology Cardiovascular
1400A: Permeabilized Fiber System – Microscope Mountable 2022
Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging Muscle Pathology & Wasting Aging
1400A: Permeabilized Fiber System – Microscope Mountable 2022
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy Muscle Pathology & Wasting Myopathy
1500A: Isolated Muscle System – Microscope Mountable 2022
Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2022
Novel γ-sarcoglycan interactors in murine muscle membranes Molecular Biology and Pharmacology Dystrophy
800A/805A: in-vitro Muscle Apparatus 2022
The road not taken: Evolution of tetrodotoxin resistance in the Sierra garter snake (Thamnophis couchii) by a path less traveled General Physiology N/A
800A/805A: in-vitro Muscle Apparatus 2022
Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression Muscle Pathology & Wasting DMD
1300A: 3-in-1 Whole Animal System for Mice 2021
In vivo Measurement of Knee Extensor Muscle Function in Mice Orthopedics Injury
1300A: 3-in-1 Whole Animal System for Mice 2021
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline Muscle Pathology & Wasting Aging
1305A: 3-in-1 Whole Animal System for Rats 2021
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2021
Impact of syndecan-2-selected mesenchymal stromal cells on the early onset of diabetic cardiomyopathy in diabetic db/db mice Cardiology Diabetes
1600A: Permeabilized Myocyte System – Microscope Mountable 2021
Representational drift in primary olfactory cortex Olfaction Odor Perception
2021
Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein Orthopedics Musculoskeletal
300C: Dual-Mode Muscle Levers 2021
Pharmacological Mitigation of Fibrosis in a Porcine Model of Volumetric Muscle Loss Injury General Physiology Volumetric Muscle Loss
2020
Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression Muscle Pathology & Wasting DMD
2021
In vivo Measurement of Knee Extensor Muscle Function in Mice Orthopedics Injury
2021
Optogenetic activation of muscle contraction in vivo Neuromuscular N/A
2021
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline