Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation.  They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Found 36 Results
Title Research Area Disease Model System/Component Year
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2021
In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes Cardiology Cardiovascular
1600A: Permeabilized Myocyte System – Microscope Mountable 2020
Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator Cardiology Cardiovascular
1600A: Permeabilized Myocyte System – Microscope Mountable 2020
Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2020
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2020
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure Muscle Pathology & Wasting Cardiovascular
615A: Dynamic Muscle Control and Analysis Software 2019
Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy Cardiology Cardiovascular
1400A: Permeabilized Fiber System – Microscope Mountable 2019
Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2017
Myocardial relaxation is accelerated by fast stretch, not reduced afterload Cardiology Cardiovascular
315D/322D: High-Speed Length Controllers 2017
Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice Molecular Biology and Pharmacology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2018
Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension. Cardiology Cardiovascular
901D: High-Speed Video Sarcomere Length 2018
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Cardiology Cardiovascular
600A: Real-Time Muscle Data Acquisition and Analysis System 2018
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Cardiology Cardiovascular
650A: Real-Time Muscle Data Acquisition and Analysis Software 2018
A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes. Cardiology Cardiovascular
901D: High-Speed Video Sarcomere Length 2017
The small-molecule fast skeletal troponin activator, CK-2127107, improves exercise tolerance in a rat model of heart failure. Exercise & Metabolism Cardiovascular
806D: in-situ Rat Apparatus 2015
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work. Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2014
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay. Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2014
Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout. Comparative Physiology Cardiovascular
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2014
Automated analysis of contractile force and Ca2+ transients in engineered heart tissue. Cardiology Cardiovascular
1400A: Permeabilized Fiber System – Microscope Mountable 2014
Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone. Cardiology Cardiovascular
1400A: Permeabilized Fiber System – Microscope Mountable 2014
Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout. Comparative Physiology Cardiovascular
1400A: Permeabilized Fiber System – Microscope Mountable 2014
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.” Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2014
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay. Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2014
Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension. Muscle Pathology & Wasting Cardiovascular
701C: Electrical Stimulator 2013
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue. Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2013
Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore. Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2013
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin Molecular Biology and Pharmacology Cardiovascular
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2013
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction. Cardiology Cardiovascular
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2013
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction. Cardiology Cardiovascular
1600A: Permeabilized Myocyte System – Microscope Mountable 2013
Contractility of myofibrils from the heart and diaphragm muscles measured with atomic force cantilevers: Effects of heart-specific deletion of arginyl-tRNA-protein transferase. Molecular Biology and Pharmacology Cardiovascular
1700A: Myofibril System – Microscope Mountable 2013
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction. Muscle Pathology & Wasting Cardiovascular
315D/322D: High-Speed Length Controllers 2012
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction. Muscle Pathology & Wasting Cardiovascular
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2012
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue. Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2013
Diaphragm muscle fiber weakness in pulmonary hypertension. Muscle Pathology & Wasting Cardiovascular
1200A: Isolated Muscle System for Mice 2011
Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices. Cardiology Cardiovascular
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2009
Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices. Cardiology Cardiovascular
1600A: Permeabilized Myocyte System – Microscope Mountable 2009
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