Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation. They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.
Strength training in older women: early and late changes in whole muscle and single cells.

Found 42 Results

Title	Research Area	Disease Model	System/Component	Year
Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues	Artificial Muscle Physiological Tissue	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2023
ERRg agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation	Artificial Muscle Physiological Tissue	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2023
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure	Muscle Pathology & Wasting	Cardiovascular	615A: Dynamic Muscle Control and Analysis Software	2019
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2021
Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2022
Reduced cardiac muscle power with low ATP simulating heart failure	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2022
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2021
Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2020
In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2020
Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2020
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2020
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure	Muscle Pathology & Wasting	Cardiovascular	615A: Dynamic Muscle Control and Analysis Software	2019
Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2019
Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice	Molecular Biology and Pharmacology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2018
Myocardial relaxation is accelerated by fast stretch, not reduced afterload	Cardiology	Cardiovascular	315D/322D: High-Speed Length Controllers	2017
Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2017
Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension.	Cardiology	Cardiovascular	901D: High-Speed Video Sarcomere Length	2018
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro.	Cardiology	Cardiovascular	650A: Real-Time Muscle Data Acquisition and Analysis Software	2018
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro.	Cardiology	Cardiovascular	600A: Real-Time Muscle Data Acquisition and Analysis System	2018
A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes.	Cardiology	Cardiovascular	901D: High-Speed Video Sarcomere Length	2017
The small-molecule fast skeletal troponin activator, CK-2127107, improves exercise tolerance in a rat model of heart failure.	Exercise & Metabolism	Cardiovascular	806D: in-situ Rat Apparatus	2015
Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout.	Comparative Physiology	Cardiovascular	802D: Permeabilized Fiber Apparatus – Microscope Mountable	2014
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2014
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2014
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay.	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2014
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.”	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2014
Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout.	Comparative Physiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2014
Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2014
Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2014
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin	Molecular Biology and Pharmacology	Cardiovascular	802D: Permeabilized Fiber Apparatus – Microscope Mountable	2013
Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension.	Muscle Pathology & Wasting	Cardiovascular	701C: Electrical Stimulator	2013
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2013
Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2013
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.	Cardiology	Cardiovascular	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2013
Contractility of myofibrils from the heart and diaphragm muscles measured with atomic force cantilevers: Effects of heart-specific deletion of arginyl-tRNA-protein transferase.	Molecular Biology and Pharmacology	Cardiovascular	1700A: Myofibril System – Microscope Mountable	2013
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2013
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2013
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction.	Muscle Pathology & Wasting	Cardiovascular	802D: Permeabilized Fiber Apparatus – Microscope Mountable	2012
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction.	Muscle Pathology & Wasting	Cardiovascular	315D/322D: High-Speed Length Controllers	2012
Diaphragm muscle fiber weakness in pulmonary hypertension.	Muscle Pathology & Wasting	Cardiovascular	1200A: Isolated Muscle System for Mice	2011
Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices.	Cardiology	Cardiovascular	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2009
Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices.	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2009

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