Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation. They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.
Strength training in older women: early and late changes in whole muscle and single cells.

Found 35 Results

Title	Research Area	Disease Model	System/Component	Year
Anti-RANKL Therapy Prevents Glucocorticoid-Induced Bone Loss and Promotes Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy	Molecular Biology and Pharmacology	DMD	1200A: Isolated Muscle System for Mice	2023
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy	Molecular Biology and Pharmacology	DMD	1400A: Permeabilized Fiber System – Microscope Mountable	2023
BAG3 Attenuates Ischemia-Induced Skeletal Muscle Necroptosis in Diabetic Experimental Peripheral Artery Disease	Molecular Biology and Pharmacology	Diabetes	1300A: 3-in-1 Whole Animal System for Mice	2022
Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS	Molecular Biology and Pharmacology	Myopathy	1300A: 3-in-1 Whole Animal System for Mice	2023
The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology	Molecular Biology and Pharmacology	Development	615A: Dynamic Muscle Control and Analysis Software	2022
SIRT1 regulates nuclear number and domain size in skeletal muscle fibers	Molecular Biology and Pharmacology	N/A		2018
Novel γ-sarcoglycan interactors in murine muscle membranes	Molecular Biology and Pharmacology	Dystrophy	800A/805A: in-vitro Muscle Apparatus	2022
microRNA‐29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery	Molecular Biology and Pharmacology	Ischmia/Reperfusion	1300A: 3-in-1 Whole Animal System for Mice	2022
RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes	Molecular Biology and Pharmacology	Atrophy	315D/322D: High-Speed Length Controllers	2018
Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle	Molecular Biology and Pharmacology	Myopathy	300C: Dual-Mode Muscle Levers	2018
Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice	Molecular Biology and Pharmacology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2018
Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.	Molecular Biology and Pharmacology	Myopathy	825A: Thermocouple Meter / TEC Controller	2015
Osteoprotegerin Protects against Muscular Dystrophy.	Molecular Biology and Pharmacology	Dystrophy	615A: Dynamic Muscle Control and Analysis Software	2015
MgADP activation contributes to force enhancement during fast stretch of isolated skeletal myofibrils.	Molecular Biology and Pharmacology	N/A	1700A: Myofibril System – Microscope Mountable	2015
Inhibition of activin A ameliorates skeletal muscle injury and rescues contractile properties by inducing efficient remodeling in female mice.	Molecular Biology and Pharmacology	Injury	807B: in-situ Large Rodent/Small Animal Apparatus	2014
Interleukin-1 Receptor Antagonist Protects against Lipopolysaccharide Induced Diaphragm Weakness in Preterm Lambs.	Molecular Biology and Pharmacology	Development	1205A: Isolated Muscle System for Rats	2015
Muscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype.	Molecular Biology and Pharmacology	Myopathy	825A: Thermocouple Meter / TEC Controller	2014
Follistatin: a novel therapeutic for the improvement of muscle regeneration.	Molecular Biology and Pharmacology	Atrophy	807B: in-situ Large Rodent/Small Animal Apparatus	2014
Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy.	Molecular Biology and Pharmacology	Atrophy	800A/805A: in-vitro Muscle Apparatus	2014
Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness.	Molecular Biology and Pharmacology	Sarcopenia	1700A: Myofibril System – Microscope Mountable	2014
Arginylation of Myosin Heavy Chain Regulates Skeletal Muscle Strength.	Molecular Biology and Pharmacology	N/A	1700A: Myofibril System – Microscope Mountable	2014
Effect of maternal steroid on developing diaphragm integrity.	Molecular Biology and Pharmacology	Development	1205A: Isolated Muscle System for Rats	2014
The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury.	Molecular Biology and Pharmacology	Injury	809C: in-situ Mouse Apparatus	2013
Whey proteins are more efficient than casein in the recovery of muscle functional properties following a casting induced muscle atrophy.	Molecular Biology and Pharmacology	Atrophy	806D: in-situ Rat Apparatus	2013
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin	Molecular Biology and Pharmacology	Cardiovascular	802D: Permeabilized Fiber Apparatus – Microscope Mountable	2013
Mitochondria-targeted antiaging gene therapy with adeno-associated viral vectors.	Molecular Biology and Pharmacology	Aging	605A: Dynamic Muscle Data Acquisition and Analysis System	2013
Contractility of myofibrils from the heart and diaphragm muscles measured with atomic force cantilevers: Effects of heart-specific deletion of arginyl-tRNA-protein transferase.	Molecular Biology and Pharmacology	Cardiovascular	1700A: Myofibril System – Microscope Mountable	2013
Mitochondria-targeted antiaging gene therapy with adeno-associated viral vectors.	Molecular Biology and Pharmacology	Aging	604A \| 604D \| 604E: Data Acquisition Signal Interface	2013
Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia.	Molecular Biology and Pharmacology	Sarcopenia	1305A: 3-in-1 Whole Animal System for Rats	2013
Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a beta2-adrenoceptor-independent mechanism.	Molecular Biology and Pharmacology	N/A	825A: Thermocouple Meter / TEC Controller	2010
Dihydrotestosterone activates the MAPK pathway and modulates maximum isometric force through the EGF receptor in isolated intact mouse skeletal muscle fibres.	Molecular Biology and Pharmacology	N/A	825A: Thermocouple Meter / TEC Controller	2010
Striated Muscles: From Molecules to Cells.	Molecular Biology and Pharmacology	N/A	1700A: Myofibril System – Microscope Mountable	2010
Androgen replacement therapy improves function in male rat muscles independently of hypertrophy and activation of the Akt/mTOR pathway.	Molecular Biology and Pharmacology	Aging	300C: Dual-Mode Muscle Levers	2009
Effects of buthionine sulfoximine treatment on diaphragm contractility and SR Ca2+ pump function in rats.	Molecular Biology and Pharmacology	N/A	605A: Dynamic Muscle Data Acquisition and Analysis System	2007
904-Plat Critical Sarcomere Length Extension and Phase Transition Of Force During Lengthening Of Skeletal Muscle Myofibrils.	Molecular Biology and Pharmacology	N/A	1700A: Myofibril System – Microscope Mountable	2008

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