Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation. They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.
Strength training in older women: early and late changes in whole muscle and single cells.

Found 53 Results

Title	Research Area	Disease Model	System/Component	Year
Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies	Muscle Pathology & Wasting	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2022
Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant	Muscle Pathology & Wasting	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2023
Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS	Molecular Biology and Pharmacology	Myopathy	1300A: 3-in-1 Whole Animal System for Mice	2023
Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility	Exercise & Metabolism	Myopathy	800A/805A: in-vitro Muscle Apparatus	2019
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy	Muscle Pathology & Wasting	Myopathy	1500A: Isolated Muscle System – Microscope Mountable	2022
Silencing of the Ca2+ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice	Muscle Pathology & Wasting	Myopathy	1305A: 3-in-1 Whole Animal System for Rats	2022
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues	General Physiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2020
Fast skeletal muscle troponin activator CK-2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction	Exercise & Metabolism	Myopathy	806D: in-situ Rat Apparatus	2019
Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy	Cardiology	Myopathy	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2019
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy	General Physiology	Myopathy	901D: High-Speed Video Sarcomere Length	2018
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy	General Physiology	Myopathy	650A: Real-Time Muscle Data Acquisition and Analysis Software	2018
Reversible temporally-specific inhibition of muscle using a light-activated chloride channel	Neuromuscular	Myopathy	300C: Dual-Mode Muscle Levers	2018
Myosin filament sliding through the Z-disc relates striated muscle fibre structure to function	General Physiology	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2016
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy	General Physiology	Myopathy	1500A: Isolated Muscle System – Microscope Mountable	2018
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes	Cardiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2018
Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle	Molecular Biology and Pharmacology	Myopathy	300C: Dual-Mode Muscle Levers	2018
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.	Cardiology	Myopathy	901D: High-Speed Video Sarcomere Length	2019
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.	Muscle Pathology & Wasting	Myopathy	650A: Real-Time Muscle Data Acquisition and Analysis Software	2019
Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin.	General Physiology	Myopathy	650A: Real-Time Muscle Data Acquisition and Analysis Software	2019
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.	Muscle Pathology & Wasting	Myopathy	600A: Real-Time Muscle Data Acquisition and Analysis System	2019
Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin.	General Physiology	Myopathy	600A: Real-Time Muscle Data Acquisition and Analysis System	2019
Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle.	General Physiology	Myopathy	950A: Calcium Fluorescence System	2015
The giant protein titin regulates the length of the striated muscle thick filament.	General Physiology	Myopathy	901D: High-Speed Video Sarcomere Length	2017
Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin.	General Physiology	Myopathy	1700A: Myofibril System – Microscope Mountable	2016
Reduced passive force in skeletal muscles lacking protein arginylation.	General Physiology	Myopathy	1700A: Myofibril System – Microscope Mountable	2016
The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms.	General Physiology	Myopathy	1700A: Myofibril System – Microscope Mountable	2016
Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations .	General Physiology	Myopathy	1700A: Myofibril System – Microscope Mountable	2016
Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.	Molecular Biology and Pharmacology	Myopathy	825A: Thermocouple Meter / TEC Controller	2015
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.	Muscle Pathology & Wasting	Myopathy	801C: Small Intact Muscle Apparatus – Microscope Mountable	2015
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy.	Muscle Pathology & Wasting	Myopathy	825A: Thermocouple Meter / TEC Controller	2014
Muscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype.	Molecular Biology and Pharmacology	Myopathy	825A: Thermocouple Meter / TEC Controller	2014
Large-Scale Modulation of Titin Elasticity by S-Glutathionylation of Cryptic Cysteines.	Cardiology	Myopathy	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.	Cardiology	Myopathy	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins	Cardiology	Myopathy	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy	Muscle Pathology & Wasting	Myopathy	802D: Permeabilized Fiber Apparatus – Microscope Mountable	2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.	Cardiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.	Cardiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy.	Muscle Pathology & Wasting	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2014
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction.	Cardiology	Myopathy	801C: Small Intact Muscle Apparatus – Microscope Mountable	2013
Force measurement during contraction to assess muscle function in zebrafish larvae.	Comparative Physiology	Myopathy	701C: Electrical Stimulator	2013
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.	General Physiology	Myopathy	802D: Permeabilized Fiber Apparatus – Microscope Mountable	2013
Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations.	Muscle Pathology & Wasting	Myopathy	315D/322D: High-Speed Length Controllers	2013
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.	General Physiology	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2013
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin.	Cardiology	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2013
Effects of alterations in sarcomere structure and prestretch timing on cardiac muscle mechanics.	Cardiology	Myopathy	1500A: Isolated Muscle System – Microscope Mountable	2012
Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model.	Muscle Pathology & Wasting	Myopathy	400B: Force Transducers	2011
Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice.	Cardiology	Myopathy	315D/322D: High-Speed Length Controllers	2010
ltered contractility of skeletal muscle in mice deficient in titin’s M-band region.	General Physiology	Myopathy	300C: Dual-Mode Muscle Levers	2009
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.	Cardiology	Myopathy	400B: Force Transducers	2001
Altered contractility of skeletal muscle in mice deficient in titin’s M-band region.	General Physiology	Myopathy		2009
Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae.	Cardiology	Myopathy	400B: Force Transducers	2008
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.	General Physiology	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2008
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C.	Cardiology	Myopathy	315D/322D: High-Speed Length Controllers	2007

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