Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation.  They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Found 47 Results
Title Research Area Disease Model System/Component Year
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues General Physiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2020
Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2019
Fast skeletal muscle troponin activator CK-2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction Exercise & Metabolism Myopathy
806D: in-situ Rat Apparatus 2019
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy General Physiology Myopathy
650A: Real-Time Muscle Data Acquisition and Analysis Software 2018
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy General Physiology Myopathy
901D: High-Speed Video Sarcomere Length 2018
Myosin filament sliding through the Z-disc relates striated muscle fibre structure to function General Physiology Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2016
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy General Physiology Myopathy
1500A: Isolated Muscle System – Microscope Mountable 2018
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes Cardiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2018
Reversible temporally-specific inhibition of muscle using a light-activated chloride channel Neuromuscular Myopathy
300C: Dual-Mode Muscle Levers 2018
Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle Molecular Biology and Pharmacology Myopathy
300C: Dual-Mode Muscle Levers 2018
Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin. General Physiology Myopathy
600A: Real-Time Muscle Data Acquisition and Analysis System 2019
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. Muscle Pathology & Wasting Myopathy
600A: Real-Time Muscle Data Acquisition and Analysis System 2019
Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin. General Physiology Myopathy
650A: Real-Time Muscle Data Acquisition and Analysis Software 2019
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. Muscle Pathology & Wasting Myopathy
650A: Real-Time Muscle Data Acquisition and Analysis Software 2019
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes. Cardiology Myopathy
901D: High-Speed Video Sarcomere Length 2019
Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene. Molecular Biology and Pharmacology Myopathy
825A: Thermocouple Meter / TEC Controller 2015
Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. General Physiology Myopathy
950A: Calcium Fluorescence System 2015
Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations . General Physiology Myopathy
1700A: Myofibril System – Microscope Mountable 2016
The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms. General Physiology Myopathy
1700A: Myofibril System – Microscope Mountable 2016
Reduced passive force in skeletal muscles lacking protein arginylation. General Physiology Myopathy
1700A: Myofibril System – Microscope Mountable 2016
Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin. General Physiology Myopathy
1700A: Myofibril System – Microscope Mountable 2016
The giant protein titin regulates the length of the striated muscle thick filament. General Physiology Myopathy
901D: High-Speed Video Sarcomere Length 2017
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes. Muscle Pathology & Wasting Myopathy
801C: Small Intact Muscle Apparatus – Microscope Mountable 2015
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy Muscle Pathology & Wasting Myopathy
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2014
Large-Scale Modulation of Titin Elasticity by S-Glutathionylation of Cryptic Cysteines. Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2014
Muscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype. Molecular Biology and Pharmacology Myopathy
825A: Thermocouple Meter / TEC Controller 2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy. Muscle Pathology & Wasting Myopathy
825A: Thermocouple Meter / TEC Controller 2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy. Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins. Cardiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cardiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2014
Force measurement during contraction to assess muscle function in zebrafish larvae. Comparative Physiology Myopathy
701C: Electrical Stimulator 2013
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction. Cardiology Myopathy
801C: Small Intact Muscle Apparatus – Microscope Mountable 2013
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice. General Physiology Myopathy
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2013
Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations. Muscle Pathology & Wasting Myopathy
315D/322D: High-Speed Length Controllers 2013
Effects of alterations in sarcomere structure and prestretch timing on cardiac muscle mechanics. Cardiology Myopathy
1500A: Isolated Muscle System – Microscope Mountable 2012
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin. Cardiology Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2013
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice. General Physiology Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2013
Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model. Muscle Pathology & Wasting Myopathy
400C: Force Transducers 2011
ltered contractility of skeletal muscle in mice deficient in titin’s M-band region. General Physiology Myopathy
300C: Dual-Mode Muscle Levers 2009
Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice. Cardiology Myopathy
315D/322D: High-Speed Length Controllers 2010
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament. Cardiology Myopathy
400C: Force Transducers 2001
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Cardiology Myopathy
315D/322D: High-Speed Length Controllers 2007
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres. General Physiology Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2008
Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae. Cardiology Myopathy
400C: Force Transducers 2008
Altered contractility of skeletal muscle in mice deficient in titin’s M-band region. General Physiology Myopathy
1200A: Isolated Muscle System for Mice 2009
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