Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation.  They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

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Found 57 Results
Title Research Area Model Product Year
Short-term aerobic exercise prevents development of glucocorticoid myopathic features in aged skeletal muscle in a sex-dependent manner Exercise & Metabolism Myopathy
1305A: 3-in-1 Whole Animal System for Rats 2024
Characterization of NEB pathogenic variants in patients reveals novel nemaline myopathy disease mechanisms and omecamtiv mecarbil force effects Muscle Pathology & Wasting Myopathy
400A: Force Transducers, 315D/322D: High-Speed Length Controllers, 802D: Permeabilized Fiber Apparatus – Microscope Mountable, 825A: Thermocouple Meter / TEC Controller, 1400A: Permeabilized Fiber System – Microscope Mountable, 901D: High-Speed Video Sarcomere Length 2024
Comprehensive phenotypic characterization of an allelic series of zebrafish models of NEB-related nemaline myopathy Muscle Pathology & Wasting Myopathy
400A: Force Transducers, 315D/322D: High-Speed Length Controllers, 901D: High-Speed Video Sarcomere Length, 701C: Electrical Stimulator 2024
Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2023
Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS Molecular Biology and Pharmacology Myopathy
1300A: 3-in-1 Whole Animal System for Mice 2023
Silencing of the Ca2+ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice Muscle Pathology & Wasting Myopathy
1305A: 3-in-1 Whole Animal System for Rats 2022
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy Muscle Pathology & Wasting Myopathy
1500A: Isolated Muscle System – Microscope Mountable 2022
Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2022
Novel ACTA1 mutation causes late-presenting nemaline myopathy with unusual dark cores Muscle Pathology & Wasting Myopathy
315D/322D: High-Speed Length Controllers, 400A: Force Transducers, 802D: Permeabilized Fiber Apparatus – Microscope Mountable, 901D: High-Speed Video Sarcomere Length, 1400A: Permeabilized Fiber System – Microscope Mountable 2021
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues General Physiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2020
Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin. General Physiology Myopathy
600A: Real-Time Muscle Data Acquisition and Analysis System 2019
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. Muscle Pathology & Wasting Myopathy
600A: Real-Time Muscle Data Acquisition and Analysis System 2019
Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin. General Physiology Myopathy
650A: Real-Time Muscle Data Acquisition and Analysis Software 2019
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. Muscle Pathology & Wasting Myopathy
650A: Real-Time Muscle Data Acquisition and Analysis Software 2019
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes. Cardiology Myopathy
901D: High-Speed Video Sarcomere Length 2019
Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2019
Fast skeletal muscle troponin activator CK-2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction Exercise & Metabolism Myopathy
806D: in-situ Rat Apparatus 2019
Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility Exercise & Metabolism Myopathy
800A/805A: in-vitro Muscle Apparatus 2019
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy General Physiology Myopathy
1500A: Isolated Muscle System – Microscope Mountable 2018
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes Cardiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2018
Reversible temporally-specific inhibition of muscle using a light-activated chloride channel Neuromuscular Myopathy
300C: Dual-Mode Muscle Levers 2018
Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle Molecular Biology and Pharmacology Myopathy
300C: Dual-Mode Muscle Levers 2018
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy General Physiology Myopathy
650A: Real-Time Muscle Data Acquisition and Analysis Software 2018
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy General Physiology Myopathy
901D: High-Speed Video Sarcomere Length 2018
The giant protein titin regulates the length of the striated muscle thick filament. General Physiology Myopathy
901D: High-Speed Video Sarcomere Length 2017
Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations . General Physiology Myopathy
1700A: Myofibril System – Microscope Mountable 2016
The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms. General Physiology Myopathy
1700A: Myofibril System – Microscope Mountable 2016
Reduced passive force in skeletal muscles lacking protein arginylation. General Physiology Myopathy
1700A: Myofibril System – Microscope Mountable 2016
Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin. General Physiology Myopathy
1700A: Myofibril System – Microscope Mountable 2016
Myosin filament sliding through the Z-disc relates striated muscle fibre structure to function General Physiology Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2016
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes. Muscle Pathology & Wasting Myopathy
801C: Small Intact Muscle Apparatus – Microscope Mountable 2015
Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene. Molecular Biology and Pharmacology Myopathy
825A: Thermocouple Meter / TEC Controller 2015
Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. General Physiology Myopathy
950A: Calcium Fluorescence System 2015
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy. Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins. Cardiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cardiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy Muscle Pathology & Wasting Myopathy
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2014
Large-Scale Modulation of Titin Elasticity by S-Glutathionylation of Cryptic Cysteines. Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2014
Muscle histopathology in nebulin-related nemaline myopathy: ultrastrastructural findings correlated to disease severity and genotype. Molecular Biology and Pharmacology Myopathy
825A: Thermocouple Meter / TEC Controller 2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy. Muscle Pathology & Wasting Myopathy
825A: Thermocouple Meter / TEC Controller 2014
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin. Cardiology Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2013
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice. General Physiology Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2013
Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations. Muscle Pathology & Wasting Myopathy
315D/322D: High-Speed Length Controllers 2013
Force measurement during contraction to assess muscle function in zebrafish larvae. Comparative Physiology Myopathy
701C: Electrical Stimulator 2013
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction. Cardiology Myopathy
801C: Small Intact Muscle Apparatus – Microscope Mountable 2013
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice. General Physiology Myopathy
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2013
Effects of alterations in sarcomere structure and prestretch timing on cardiac muscle mechanics. Cardiology Myopathy
1500A: Isolated Muscle System – Microscope Mountable 2012
Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model. Muscle Pathology & Wasting Myopathy
400B: Force Transducers 2011
Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice. Cardiology Myopathy
315D/322D: High-Speed Length Controllers 2010
Altered contractility of skeletal muscle in mice deficient in titin’s M-band region. General Physiology Myopathy
1200A: Isolated Muscle System for Rodents 2009
ltered contractility of skeletal muscle in mice deficient in titin’s M-band region. General Physiology Myopathy
300C: Dual-Mode Muscle Levers 2009
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres. General Physiology Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2008
Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae. Cardiology Myopathy
400B: Force Transducers 2008
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Cardiology Myopathy
315D/322D: High-Speed Length Controllers 2007
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament. Cardiology Myopathy
400B: Force Transducers 2001
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