Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation. They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.
Strength training in older women: early and late changes in whole muscle and single cells.

Found 100 Results

Title	Research Area	Disease Model	System/Component	Year
MYTHO is a novel regulator of skeletal muscle autophagy and integrity	Muscle Pathology & Wasting	Atrophy		2023
Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress	Muscle Pathology & Wasting	Cachexia	1300A: 3-in-1 Whole Animal System for Mice	2022
Microdystrophin Gene Addition Significantly Improves Muscle Functionality and Diaphragm Muscle Histopathology in a Fibrotic Mouse Model of Duchenne Muscular Dystrophy	Muscle Pathology & Wasting	DMD	1300A: 3-in-1 Whole Animal System for Mice	2023
Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth	Muscle Pathology & Wasting	Cancer	1200A: Isolated Muscle System for Mice	2023
Optimization and construct validity of approaches to preclinical grip strength testing	Muscle Pathology & Wasting	Aging	1300A: 3-in-1 Whole Animal System for Mice	2023
Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies	Muscle Pathology & Wasting	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2022
Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant	Muscle Pathology & Wasting	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2023
Effects of hindlimb suspension and reloading on gastrocnemius and soleus muscle mass and function in geriatric mice	Muscle Pathology & Wasting	Aging	615A: Dynamic Muscle Control and Analysis Software	2019
Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy	Muscle Pathology & Wasting	Dystrophy	800A/805A: in-vitro Muscle Apparatus	2021
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure	Muscle Pathology & Wasting	Cardiovascular	615A: Dynamic Muscle Control and Analysis Software	2019
Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit	Muscle Pathology & Wasting	Dystrophy	800A/805A: in-vitro Muscle Apparatus	2018
Contributions of Titin and Collagen to Passive Stress in Muscles from mdm Mice with a Small Deletion in Titin’s Molecular Spring	Muscle Pathology & Wasting	Dystrophy		2022
FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy	Muscle Pathology & Wasting	Dystrophy		2021
Efficient precise in vivo base editing in adultdystrophic mice	Muscle Pathology & Wasting	DMD		2021
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline	Muscle Pathology & Wasting	Aging	1305A: 3-in-1 Whole Animal System for Rats	2021
Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression	Muscle Pathology & Wasting	DMD	1300A: 3-in-1 Whole Animal System for Mice	2021
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy	Muscle Pathology & Wasting	Myopathy	1500A: Isolated Muscle System – Microscope Mountable	2022
Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging	Muscle Pathology & Wasting	Aging	1400A: Permeabilized Fiber System – Microscope Mountable	2022
Silencing of the Ca2+ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice	Muscle Pathology & Wasting	Myopathy	1305A: 3-in-1 Whole Animal System for Rats	2022
Influenza A Virus-Driven Airway Inflammation may be Dissociated From Limb Muscle Atrophy in Cigarette Smoke-Exposed Mice	Muscle Pathology & Wasting	Atrophy	1300A: 3-in-1 Whole Animal System for Mice	2022
Dose-Escalation Study of Systemically Delivered rAAVrh74.MHCK7.micro-dystrophin in the mdx Mouse Model of Duchenne Muscular Dystrophy	Muscle Pathology & Wasting	DMD		2021
Efficient precise in vivo base editing in adultdystrophic mice	Muscle Pathology & Wasting	DMD		2021
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline	Muscle Pathology & Wasting	Aging	1305A: 3-in-1 Whole Animal System for Rats	2021
Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression	Muscle Pathology & Wasting	DMD		2021
Mechanical Properties of Single Muscle Fibers: Understanding Poor Muscle Quality in Older Adults with Diabetes	Muscle Pathology & Wasting	Diabetes	315D/322D: High-Speed Length Controllers	2020
A novel ex vivo protocol to mimic human walking gait: implications for Duchenne muscular dystrophy	Muscle Pathology & Wasting	DMD	1300A: 3-in-1 Whole Animal System for Mice	2020
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals	Muscle Pathology & Wasting	Atrophy	300C: Dual-Mode Muscle Levers	2020
Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury	Muscle Pathology & Wasting	Aging	1200A: Isolated Muscle System for Mice	2020
Dietary nitrate supplementation increases diaphragm peak power in old mice	Muscle Pathology & Wasting	Aging	1200A: Isolated Muscle System for Mice	2020
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle	Muscle Pathology & Wasting	Aging	809C: in-situ Mouse Apparatus	2019
Effects of Prolonged Dietary Curcumin Exposure on Skeletal Muscle Biochemical and Functional Responses of Aged Male Rats	Muscle Pathology & Wasting	Aging, Atrophy, Sarcopenia		2019
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure	Muscle Pathology & Wasting	Cardiovascular	615A: Dynamic Muscle Control and Analysis Software	2019
Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness	Muscle Pathology & Wasting	Atrophy	1200A: Isolated Muscle System for Mice	2019
Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass	Muscle Pathology & Wasting	Aging	615A: Dynamic Muscle Control and Analysis Software	2018
Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice	Muscle Pathology & Wasting	Atrophy	615A: Dynamic Muscle Control and Analysis Software	2018
Myeloid Cell Responses to Contraction-induced Injury Differ in Muscles of Young and Old Mice	Muscle Pathology & Wasting	Aging	701C: Electrical Stimulator	2018
Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit	Muscle Pathology & Wasting	Dystrophy	800A/805A: in-vitro Muscle Apparatus	2018
Titin-based mechanosensing modulates muscle hypertrophy	Muscle Pathology & Wasting	Sarcopenia	802D: Permeabilized Fiber Apparatus – Microscope Mountable	2018
Chemotherapy-induced loss of bone and muscle mass in a mouse model of breast cancer bone metastases and cachexia	Muscle Pathology & Wasting	Cachexia	1200A: Isolated Muscle System for Mice	2019
PERK regulates skeletal muscle mass and contractile function in adult mice	Muscle Pathology & Wasting	Cachexia	1300A: 3-in-1 Whole Animal System for Mice	2019
Parkin overexpression protects from ageing-related loss of muscle mass and strength	Muscle Pathology & Wasting	Aging	1300A: 3-in-1 Whole Animal System for Mice	2019
Muscle weakness in a S. pneumoniae sepsis mouse model	Muscle Pathology & Wasting	Atrophy	1400A: Permeabilized Fiber System – Microscope Mountable	2019
Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A	Muscle Pathology & Wasting	Dystrophy	1500A: Isolated Muscle System – Microscope Mountable	2019
Titin-based mechanosensing modulates muscle hypertrophy	Muscle Pathology & Wasting	Sarcopenia	315D/322D: High-Speed Length Controllers	2018
Skeletal muscle function during the progression of cancer cachexia in the male ApcMin/+ mouse	Muscle Pathology & Wasting	Cachexia	1300A: 3-in-1 Whole Animal System for Mice	2018
Oxidative stress-induced dysregulation of excitation–contraction coupling contributes to muscle weakness	Muscle Pathology & Wasting	Sarcopenia	1200A: Isolated Muscle System for Mice	2018
Contractile efficiency of dystrophic mdx mouse muscle: in vivo and ex vivo assessment of adaptation to exercise of functional end points	Muscle Pathology & Wasting	DMD	615A: Dynamic Muscle Control and Analysis Software	2017
Glucocorticoids Induce Bone and Muscle Atrophy by Tissue-Specific Mechanisms Upstream of E3 Ubiquitin Ligases	Muscle Pathology & Wasting	Musculoskeletal	1305A: 3-in-1 Whole Animal System for Rats	2017
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.	Muscle Pathology & Wasting	Myopathy	650A: Real-Time Muscle Data Acquisition and Analysis Software	2019
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.	Muscle Pathology & Wasting	Myopathy	600A: Real-Time Muscle Data Acquisition and Analysis System	2019
Characterization of a compartment syndrome-like injury model.	Muscle Pathology & Wasting	Injury	806D: in-situ Rat Apparatus	2015
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.	Muscle Pathology & Wasting	Myopathy	801C: Small Intact Muscle Apparatus – Microscope Mountable	2015
Human trachealis and main bronchi smooth muscle are normoresponsive in asthma.	Muscle Pathology & Wasting	Asthma	650A: Real-Time Muscle Data Acquisition and Analysis Software	2015
Human trachealis and main bronchi smooth muscle are normoresponsive in asthma.	Muscle Pathology & Wasting	Asthma	600A: Real-Time Muscle Data Acquisition and Analysis System	2015
Masticatory muscles of mouse do not undergo atrophy in space.	Muscle Pathology & Wasting	Atrophy	1700A: Myofibril System – Microscope Mountable	2015
Xin-deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality.	Muscle Pathology & Wasting	Dystrophy	1300A: 3-in-1 Whole Animal System for Mice	2015
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy	Muscle Pathology & Wasting	Myopathy	802D: Permeabilized Fiber Apparatus – Microscope Mountable	2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions.	Muscle Pathology & Wasting	Dystrophy	806D: in-situ Rat Apparatus	2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy.	Muscle Pathology & Wasting	Myopathy	825A: Thermocouple Meter / TEC Controller	2014
Long-term effects of Combat Ready Clamp application to control junctional hemorrhage in swine.	Muscle Pathology & Wasting	Ischmia/Reperfusion	890A: in-situ Large Animal Apparatus	2014
Functional, morphological, and apoptotic alterations in skeletal muscle of ARC deficient mice.	Muscle Pathology & Wasting	Atrophy		2015
Single muscle contractile measurements in vivo and in situ.	Muscle Pathology & Wasting	Dystrophy	1300A: 3-in-1 Whole Animal System for Mice	2015
Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice.	Muscle Pathology & Wasting	DMD	615A: Dynamic Muscle Control and Analysis Software	2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions.	Muscle Pathology & Wasting	Dystrophy	605A: Dynamic Muscle Data Acquisition and Analysis System	2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions.	Muscle Pathology & Wasting	Dystrophy	604A \| 604D \| 604E: Data Acquisition Signal Interface	2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy.	Muscle Pathology & Wasting	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions.	Muscle Pathology & Wasting	Dystrophy	1305A: 3-in-1 Whole Animal System for Rats	2014
Aging-related changes in the iron status of skeletal muscle.	Muscle Pathology & Wasting	Aging	806D: in-situ Rat Apparatus	2013
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice.	Muscle Pathology & Wasting	Dystrophy	800A/805A: in-vitro Muscle Apparatus	2013
Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension.	Muscle Pathology & Wasting	Cardiovascular	701C: Electrical Stimulator	2013
Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations.	Muscle Pathology & Wasting	Myopathy	315D/322D: High-Speed Length Controllers	2013
Diaphragm and ventilatory dysfunction during cancer cachexia.	Muscle Pathology & Wasting	Cachexia	300C: Dual-Mode Muscle Levers	2013
Diaphragm and ventilatory dysfunction during cancer cachexia.	Muscle Pathology & Wasting	Cachexia	315D/322D: High-Speed Length Controllers	2013
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice.	Muscle Pathology & Wasting	Dystrophy	604A \| 604D \| 604E: Data Acquisition Signal Interface	2013
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice.	Muscle Pathology & Wasting	Dystrophy	605A: Dynamic Muscle Data Acquisition and Analysis System	2013
Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice.	Muscle Pathology & Wasting	DMD	615A: Dynamic Muscle Control and Analysis Software	2013
Diaphragm and ventilatory dysfunction during cancer cachexia.	Muscle Pathology & Wasting	Cachexia	701C: Electrical Stimulator	2013
Neuromuscular Electrical Stimulation as a Method to Maximize the Beneficial Effects of Muscle Stem Cells Transplanted into Dystrophic Skeletal Muscle.	Muscle Pathology & Wasting	Dystrophy	1300A: 3-in-1 Whole Animal System for Mice	2013
Isometric and eccentric force generation assessment of skeletal muscles isolated from murine models of muscular dystrophies.	Muscle Pathology & Wasting	Dystrophy		2013
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction.	Muscle Pathology & Wasting	Cardiovascular	802D: Permeabilized Fiber Apparatus – Microscope Mountable	2012
Skeletal muscle weakness caused by carrageenan-induced inflammation.	Muscle Pathology & Wasting	Sarcopenia	615A: Dynamic Muscle Control and Analysis Software	2012
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction.	Muscle Pathology & Wasting	Cardiovascular	315D/322D: High-Speed Length Controllers	2012
Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy.	Muscle Pathology & Wasting	DMD	615A: Dynamic Muscle Control and Analysis Software	2011
Diaphragm muscle fiber weakness in pulmonary hypertension.	Muscle Pathology & Wasting	Cardiovascular	1200A: Isolated Muscle System for Mice	2011
Sustained release of bone morphogenetic protein-4 in adult rabbit extraocular muscle results in decreased force and muscle size: potential for strabismus treatment.	Muscle Pathology & Wasting	N/A	1205A: Isolated Muscle System for Rats	2011
Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice.	Muscle Pathology & Wasting	Sarcopenia	300C: Dual-Mode Muscle Levers	2011
Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model.	Muscle Pathology & Wasting	Myopathy	400B: Force Transducers	2011
In vivo canine muscle function assay.	Muscle Pathology & Wasting	Dystrophy	604A \| 604D \| 604E: Data Acquisition Signal Interface	2011
In vivo canine muscle function assay.	Muscle Pathology & Wasting	Dystrophy	890A: in-situ Large Animal Apparatus	2011
The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2- to 20-mo-old mdx mice.	Muscle Pathology & Wasting	DMD	615A: Dynamic Muscle Control and Analysis Software	2011
Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy.	Muscle Pathology & Wasting	DMD	701C: Electrical Stimulator	2011
Skeletal muscle weakness caused by carrageenan-induced inflammation.	Muscle Pathology & Wasting	Sarcopenia		2012
Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping.	Muscle Pathology & Wasting	Dystrophy	605A: Dynamic Muscle Data Acquisition and Analysis System	2010
Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping.	Muscle Pathology & Wasting	Dystrophy	604A \| 604D \| 604E: Data Acquisition Signal Interface	2010
Combination of myostatin pathway interference and dystrophin rescue enhances tetanic and specific force in dystrophic mdx mice.	Muscle Pathology & Wasting	DMD	300C: Dual-Mode Muscle Levers	2010
Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice.	Muscle Pathology & Wasting	Atrophy	1200A: Isolated Muscle System for Mice	2010
Single muscle fiber contractile properties in adults with muscular dystrophy treated with MYO‐029.	Muscle Pathology & Wasting	DMD	400B: Force Transducers	2009
Muscle fiber size and function in elderly humans: a longitudinal study.	Muscle Pathology & Wasting	Aging	400B: Force Transducers	2008
Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from mdx mice.	Muscle Pathology & Wasting	DMD	400B: Force Transducers	2008
Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury.	Muscle Pathology & Wasting	DMD	605A: Dynamic Muscle Data Acquisition and Analysis System	2005

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