Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation.  They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Found 100 Results
Title Research Area Disease Model System/Component Year
MYTHO is a novel regulator of skeletal muscle autophagy and integrity Muscle Pathology & Wasting Atrophy
2023
Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress Muscle Pathology & Wasting Cachexia
2022
Microdystrophin Gene Addition Significantly Improves Muscle Functionality and Diaphragm Muscle Histopathology in a Fibrotic Mouse Model of Duchenne Muscular Dystrophy Muscle Pathology & Wasting DMD
2023
Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth Muscle Pathology & Wasting Cancer
2023
Optimization and construct validity of approaches to preclinical grip strength testing Muscle Pathology & Wasting Aging
1300A: 3-in-1 Whole Animal System for Mice 2023
Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2022
Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2023
Effects of hindlimb suspension and reloading on gastrocnemius and soleus muscle mass and function in geriatric mice Muscle Pathology & Wasting Aging
615A: Dynamic Muscle Control and Analysis Software 2019
Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy Muscle Pathology & Wasting Dystrophy
800A/805A: in-vitro Muscle Apparatus 2021
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure Muscle Pathology & Wasting Cardiovascular
615A: Dynamic Muscle Control and Analysis Software 2019
Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit Muscle Pathology & Wasting Dystrophy
800A/805A: in-vitro Muscle Apparatus 2018
Contributions of Titin and Collagen to Passive Stress in Muscles from mdm Mice with a Small Deletion in Titin’s Molecular Spring Muscle Pathology & Wasting Dystrophy
2022
FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy Muscle Pathology & Wasting Dystrophy
2021
Efficient precise in vivo base editing in adultdystrophic mice Muscle Pathology & Wasting DMD
2021
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline Muscle Pathology & Wasting Aging
1305A: 3-in-1 Whole Animal System for Rats 2021
Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression Muscle Pathology & Wasting DMD
1300A: 3-in-1 Whole Animal System for Mice 2021
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy Muscle Pathology & Wasting Myopathy
1500A: Isolated Muscle System – Microscope Mountable 2022
Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging Muscle Pathology & Wasting Aging
1400A: Permeabilized Fiber System – Microscope Mountable 2022
Silencing of the Ca2+ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice Muscle Pathology & Wasting Myopathy
1305A: 3-in-1 Whole Animal System for Rats 2022
Influenza A Virus-Driven Airway Inflammation may be Dissociated From Limb Muscle Atrophy in Cigarette Smoke-Exposed Mice Muscle Pathology & Wasting Atrophy
1300A: 3-in-1 Whole Animal System for Mice 2022
Dose-Escalation Study of Systemically Delivered rAAVrh74.MHCK7.micro-dystrophin in the mdx Mouse Model of Duchenne Muscular Dystrophy Muscle Pathology & Wasting DMD
2021
Efficient precise in vivo base editing in adultdystrophic mice Muscle Pathology & Wasting DMD
2021
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline Muscle Pathology & Wasting Aging
1305A: 3-in-1 Whole Animal System for Rats 2021
Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression Muscle Pathology & Wasting DMD
2021
Mechanical Properties of Single Muscle Fibers: Understanding Poor Muscle Quality in Older Adults with Diabetes Muscle Pathology & Wasting Diabetes
315D/322D: High-Speed Length Controllers 2020
A novel ex vivo protocol to mimic human walking gait: implications for Duchenne muscular dystrophy Muscle Pathology & Wasting DMD
1300A: 3-in-1 Whole Animal System for Mice 2020
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals Muscle Pathology & Wasting Atrophy
300C: Dual-Mode Muscle Levers 2020
Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury Muscle Pathology & Wasting Aging
1200A: Isolated Muscle System for Mice 2020
Dietary nitrate supplementation increases diaphragm peak power in old mice Muscle Pathology & Wasting Aging
1200A: Isolated Muscle System for Mice 2020
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle Muscle Pathology & Wasting Aging
809C: in-situ Mouse Apparatus 2019
Effects of Prolonged Dietary Curcumin Exposure on Skeletal Muscle Biochemical and Functional Responses of Aged Male Rats Muscle Pathology & Wasting Aging, Atrophy, Sarcopenia
2019
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure Muscle Pathology & Wasting Cardiovascular
615A: Dynamic Muscle Control and Analysis Software 2019
Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness Muscle Pathology & Wasting Atrophy
1200A: Isolated Muscle System for Mice 2019
Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass Muscle Pathology & Wasting Aging
615A: Dynamic Muscle Control and Analysis Software 2018
Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice Muscle Pathology & Wasting Atrophy
615A: Dynamic Muscle Control and Analysis Software 2018
Myeloid Cell Responses to Contraction-induced Injury Differ in Muscles of Young and Old Mice Muscle Pathology & Wasting Aging
701C: Electrical Stimulator 2018
Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit Muscle Pathology & Wasting Dystrophy
800A/805A: in-vitro Muscle Apparatus 2018
Titin-based mechanosensing modulates muscle hypertrophy Muscle Pathology & Wasting Sarcopenia
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2018
Chemotherapy-induced loss of bone and muscle mass in a mouse model of breast cancer bone metastases and cachexia Muscle Pathology & Wasting Cachexia
1200A: Isolated Muscle System for Mice 2019
PERK regulates skeletal muscle mass and contractile function in adult mice Muscle Pathology & Wasting Cachexia
1300A: 3-in-1 Whole Animal System for Mice 2019
Parkin overexpression protects from ageing-related loss of muscle mass and strength Muscle Pathology & Wasting Aging
1300A: 3-in-1 Whole Animal System for Mice 2019
Muscle weakness in a S. pneumoniae sepsis mouse model Muscle Pathology & Wasting Atrophy
1400A: Permeabilized Fiber System – Microscope Mountable 2019
Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A Muscle Pathology & Wasting Dystrophy
1500A: Isolated Muscle System – Microscope Mountable 2019
Titin-based mechanosensing modulates muscle hypertrophy Muscle Pathology & Wasting Sarcopenia
315D/322D: High-Speed Length Controllers 2018
Skeletal muscle function during the progression of cancer cachexia in the male ApcMin/+ mouse Muscle Pathology & Wasting Cachexia
1300A: 3-in-1 Whole Animal System for Mice 2018
Oxidative stress-induced dysregulation of excitation–contraction coupling contributes to muscle weakness Muscle Pathology & Wasting Sarcopenia
1200A: Isolated Muscle System for Mice 2018
Contractile efficiency of dystrophic mdx mouse muscle: in vivo and ex vivo assessment of adaptation to exercise of functional end points Muscle Pathology & Wasting DMD
615A: Dynamic Muscle Control and Analysis Software 2017
Glucocorticoids Induce Bone and Muscle Atrophy by Tissue-Specific Mechanisms Upstream of E3 Ubiquitin Ligases Muscle Pathology & Wasting Musculoskeletal
1305A: 3-in-1 Whole Animal System for Rats 2017
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. Muscle Pathology & Wasting Myopathy
650A: Real-Time Muscle Data Acquisition and Analysis Software 2019
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. Muscle Pathology & Wasting Myopathy
600A: Real-Time Muscle Data Acquisition and Analysis System 2019
Characterization of a compartment syndrome-like injury model. Muscle Pathology & Wasting Injury
806D: in-situ Rat Apparatus 2015
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes. Muscle Pathology & Wasting Myopathy
801C: Small Intact Muscle Apparatus – Microscope Mountable 2015
Human trachealis and main bronchi smooth muscle are normoresponsive in asthma. Muscle Pathology & Wasting Asthma
650A: Real-Time Muscle Data Acquisition and Analysis Software 2015
Human trachealis and main bronchi smooth muscle are normoresponsive in asthma. Muscle Pathology & Wasting Asthma
600A: Real-Time Muscle Data Acquisition and Analysis System 2015
Masticatory muscles of mouse do not undergo atrophy in space. Muscle Pathology & Wasting Atrophy
1700A: Myofibril System – Microscope Mountable 2015
Xin-deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality. Muscle Pathology & Wasting Dystrophy
1300A: 3-in-1 Whole Animal System for Mice 2015
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy Muscle Pathology & Wasting Myopathy
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions. Muscle Pathology & Wasting Dystrophy
806D: in-situ Rat Apparatus 2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy. Muscle Pathology & Wasting Myopathy
825A: Thermocouple Meter / TEC Controller 2014
Long-term effects of Combat Ready Clamp application to control junctional hemorrhage in swine. Muscle Pathology & Wasting Ischmia/Reperfusion
890A: in-situ Large Animal Apparatus 2014
Functional, morphological, and apoptotic alterations in skeletal muscle of ARC deficient mice. Muscle Pathology & Wasting Atrophy
2015
Single muscle contractile measurements in vivo and in situ. Muscle Pathology & Wasting Dystrophy
1300A: 3-in-1 Whole Animal System for Mice 2015
Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice. Muscle Pathology & Wasting DMD
615A: Dynamic Muscle Control and Analysis Software 2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions. Muscle Pathology & Wasting Dystrophy
605A: Dynamic Muscle Data Acquisition and Analysis System 2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions. Muscle Pathology & Wasting Dystrophy
604A | 604D | 604E: Data Acquisition Signal Interface 2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy. Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions. Muscle Pathology & Wasting Dystrophy
1305A: 3-in-1 Whole Animal System for Rats 2014
Aging-related changes in the iron status of skeletal muscle. Muscle Pathology & Wasting Aging
806D: in-situ Rat Apparatus 2013
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice. Muscle Pathology & Wasting Dystrophy
800A/805A: in-vitro Muscle Apparatus 2013
Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension. Muscle Pathology & Wasting Cardiovascular
701C: Electrical Stimulator 2013
Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations. Muscle Pathology & Wasting Myopathy
315D/322D: High-Speed Length Controllers 2013
Diaphragm and ventilatory dysfunction during cancer cachexia. Muscle Pathology & Wasting Cachexia
300C: Dual-Mode Muscle Levers 2013
Diaphragm and ventilatory dysfunction during cancer cachexia. Muscle Pathology & Wasting Cachexia
315D/322D: High-Speed Length Controllers 2013
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice. Muscle Pathology & Wasting Dystrophy
604A | 604D | 604E: Data Acquisition Signal Interface 2013
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice. Muscle Pathology & Wasting Dystrophy
605A: Dynamic Muscle Data Acquisition and Analysis System 2013
Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice. Muscle Pathology & Wasting DMD
615A: Dynamic Muscle Control and Analysis Software 2013
Diaphragm and ventilatory dysfunction during cancer cachexia. Muscle Pathology & Wasting Cachexia
701C: Electrical Stimulator 2013
Neuromuscular Electrical Stimulation as a Method to Maximize the Beneficial Effects of Muscle Stem Cells Transplanted into Dystrophic Skeletal Muscle. Muscle Pathology & Wasting Dystrophy
1300A: 3-in-1 Whole Animal System for Mice 2013
Isometric and eccentric force generation assessment of skeletal muscles isolated from murine models of muscular dystrophies. Muscle Pathology & Wasting Dystrophy
2013
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction. Muscle Pathology & Wasting Cardiovascular
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2012
Skeletal muscle weakness caused by carrageenan-induced inflammation. Muscle Pathology & Wasting Sarcopenia
615A: Dynamic Muscle Control and Analysis Software 2012
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction. Muscle Pathology & Wasting Cardiovascular
315D/322D: High-Speed Length Controllers 2012
Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy. Muscle Pathology & Wasting DMD
615A: Dynamic Muscle Control and Analysis Software 2011
Diaphragm muscle fiber weakness in pulmonary hypertension. Muscle Pathology & Wasting Cardiovascular
1200A: Isolated Muscle System for Mice 2011
Sustained release of bone morphogenetic protein-4 in adult rabbit extraocular muscle results in decreased force and muscle size: potential for strabismus treatment. Muscle Pathology & Wasting N/A
1205A: Isolated Muscle System for Rats 2011
Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice. Muscle Pathology & Wasting Sarcopenia
300C: Dual-Mode Muscle Levers 2011
Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model. Muscle Pathology & Wasting Myopathy
400B: Force Transducers 2011
In vivo canine muscle function assay. Muscle Pathology & Wasting Dystrophy
604A | 604D | 604E: Data Acquisition Signal Interface 2011
In vivo canine muscle function assay. Muscle Pathology & Wasting Dystrophy
890A: in-situ Large Animal Apparatus 2011
The passive mechanical properties of the extensor digitorum longus muscle are compromised in