Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation.  They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Found 79 Results
Title Research Area Disease Model System/Component Year
Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression Muscle Pathology & Wasting DMD
1300A: 3-in-1 Whole Animal System for Mice 2021
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline Muscle Pathology & Wasting Aging
1305A: 3-in-1 Whole Animal System for Rats 2021
Efficient precise in vivo base editing in adultdystrophic mice Muscle Pathology & Wasting DMD
1300A: 3-in-1 Whole Animal System for Mice 2021
Dose-Escalation Study of Systemically Delivered rAAVrh74.MHCK7.micro-dystrophin in the mdx Mouse Model of Duchenne Muscular Dystrophy Muscle Pathology & Wasting DMD
1305A: 3-in-1 Whole Animal System for Rats 2021
A novel ex vivo protocol to mimic human walking gait: implications for Duchenne muscular dystrophy Muscle Pathology & Wasting DMD
1300A: 3-in-1 Whole Animal System for Mice 2020
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals Muscle Pathology & Wasting Atrophy
300C: Dual-Mode Muscle Levers 2020
Mechanical Properties of Single Muscle Fibers: Understanding Poor Muscle Quality in Older Adults with Diabetes Muscle Pathology & Wasting Diabetes
315D/322D: High-Speed Length Controllers 2020
Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure Muscle Pathology & Wasting Cardiovascular
615A: Dynamic Muscle Control and Analysis Software 2019
Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle Muscle Pathology & Wasting Aging
809C: in-situ Mouse Apparatus 2019
Dietary nitrate supplementation increases diaphragm peak power in old mice Muscle Pathology & Wasting Aging
1200A: Isolated Muscle System for Mice 2020
Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury Muscle Pathology & Wasting Aging
1200A: Isolated Muscle System for Mice 2020
Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass Muscle Pathology & Wasting Aging
615A: Dynamic Muscle Control and Analysis Software 2018
Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice Muscle Pathology & Wasting Atrophy
615A: Dynamic Muscle Control and Analysis Software 2018
Myeloid Cell Responses to Contraction-induced Injury Differ in Muscles of Young and Old Mice Muscle Pathology & Wasting Aging
701C: Electrical Stimulator 2018
Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit Muscle Pathology & Wasting Dystrophy
800A/805A: in-vitro Muscle Apparatus 2018
Titin-based mechanosensing modulates muscle hypertrophy Muscle Pathology & Wasting Sarcopenia
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2018
Chemotherapy-induced loss of bone and muscle mass in a mouse model of breast cancer bone metastases and cachexia Muscle Pathology & Wasting Cachexia
1200A: Isolated Muscle System for Mice 2019
Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness Muscle Pathology & Wasting Atrophy
1200A: Isolated Muscle System for Mice 2019
PERK regulates skeletal muscle mass and contractile function in adult mice Muscle Pathology & Wasting Cachexia
1300A: 3-in-1 Whole Animal System for Mice 2019
Parkin overexpression protects from ageing-related loss of muscle mass and strength Muscle Pathology & Wasting Aging
1300A: 3-in-1 Whole Animal System for Mice 2019
Muscle weakness in a S. pneumoniae sepsis mouse model Muscle Pathology & Wasting Atrophy
1400A: Permeabilized Fiber System – Microscope Mountable 2019
Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A Muscle Pathology & Wasting Dystrophy
1500A: Isolated Muscle System – Microscope Mountable 2019
Glucocorticoids Induce Bone and Muscle Atrophy by Tissue-Specific Mechanisms Upstream of E3 Ubiquitin Ligases Muscle Pathology & Wasting Musculoskeletal
1305A: 3-in-1 Whole Animal System for Rats 2017
Contractile efficiency of dystrophic mdx mouse muscle: in vivo and ex vivo assessment of adaptation to exercise of functional end points Muscle Pathology & Wasting DMD
615A: Dynamic Muscle Control and Analysis Software 2017
Oxidative stress-induced dysregulation of excitation–contraction coupling contributes to muscle weakness Muscle Pathology & Wasting Sarcopenia
1200A: Isolated Muscle System for Mice 2018
Skeletal muscle function during the progression of cancer cachexia in the male ApcMin/+ mouse Muscle Pathology & Wasting Cachexia
1300A: 3-in-1 Whole Animal System for Mice 2018
Titin-based mechanosensing modulates muscle hypertrophy Muscle Pathology & Wasting Sarcopenia
315D/322D: High-Speed Length Controllers 2018
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. Muscle Pathology & Wasting Myopathy
600A: Real-Time Muscle Data Acquisition and Analysis System 2019
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. Muscle Pathology & Wasting Myopathy
650A: Real-Time Muscle Data Acquisition and Analysis Software 2019
Xin-deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality. Muscle Pathology & Wasting Dystrophy
1300A: 3-in-1 Whole Animal System for Mice 2015
Masticatory muscles of mouse do not undergo atrophy in space. Muscle Pathology & Wasting Atrophy
1700A: Myofibril System – Microscope Mountable 2015
Human trachealis and main bronchi smooth muscle are normoresponsive in asthma. Muscle Pathology & Wasting Asthma
600A: Real-Time Muscle Data Acquisition and Analysis System 2015
Human trachealis and main bronchi smooth muscle are normoresponsive in asthma. Muscle Pathology & Wasting Asthma
650A: Real-Time Muscle Data Acquisition and Analysis Software 2015
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes. Muscle Pathology & Wasting Myopathy
801C: Small Intact Muscle Apparatus – Microscope Mountable 2015
Characterization of a compartment syndrome-like injury model. Muscle Pathology & Wasting Injury
806D: in-situ Rat Apparatus 2015
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy Muscle Pathology & Wasting Myopathy
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions. Muscle Pathology & Wasting Dystrophy
806D: in-situ Rat Apparatus 2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy. Muscle Pathology & Wasting Myopathy
825A: Thermocouple Meter / TEC Controller 2014
Long-term effects of Combat Ready Clamp application to control junctional hemorrhage in swine. Muscle Pathology & Wasting Ischmia/Reperfusion
890A: in-situ Large Animal Apparatus 2014
Functional, morphological, and apoptotic alterations in skeletal muscle of ARC deficient mice. Muscle Pathology & Wasting Atrophy
1200A: Isolated Muscle System for Mice 2015
Single muscle contractile measurements in vivo and in situ. Muscle Pathology & Wasting Dystrophy
1300A: 3-in-1 Whole Animal System for Mice 2015
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy. Muscle Pathology & Wasting Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions. Muscle Pathology & Wasting Dystrophy
604A: Data Acquisition Signal Interface 2014
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions. Muscle Pathology & Wasting Dystrophy
605A: Dynamic Muscle Data Acquisition and Analysis System 2014
Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice. Muscle Pathology & Wasting DMD
615A: Dynamic Muscle Control and Analysis Software 2014
Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension. Muscle Pathology & Wasting Cardiovascular
701C: Electrical Stimulator 2013
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice. Muscle Pathology & Wasting Dystrophy
800A/805A: in-vitro Muscle Apparatus 2013
Aging-related changes in the iron status of skeletal muscle. Muscle Pathology & Wasting Aging
806D: in-situ Rat Apparatus 2013
Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions. Muscle Pathology & Wasting Dystrophy
1305A: 3-in-1 Whole Animal System for Rats 2014
Diaphragm and ventilatory dysfunction during cancer cachexia. Muscle Pathology & Wasting Cachexia
300C: Dual-Mode Muscle Levers 2013
Diaphragm and ventilatory dysfunction during cancer cachexia. Muscle Pathology & Wasting Cachexia
315D/322D: High-Speed Length Controllers 2013
Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations. Muscle Pathology & Wasting Myopathy
315D/322D: High-Speed Length Controllers 2013
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice. Muscle Pathology & Wasting Dystrophy
604A: Data Acquisition Signal Interface 2013
Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice. Muscle Pathology & Wasting Dystrophy
605A: Dynamic Muscle Data Acquisition and Analysis System 2013
Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice. Muscle Pathology & Wasting DMD
615A: Dynamic Muscle Control and Analysis Software 2013
Diaphragm and ventilatory dysfunction during cancer cachexia. Muscle Pathology & Wasting Cachexia
701C: Electrical Stimulator 2013
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction. Muscle Pathology & Wasting Cardiovascular
315D/322D: High-Speed Length Controllers 2012
Skeletal muscle weakness caused by carrageenan-induced inflammation. Muscle Pathology & Wasting Sarcopenia
615A: Dynamic Muscle Control and Analysis Software 2012
Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction. Muscle Pathology & Wasting Cardiovascular
802D: Permeabilized Fiber Apparatus – Microscope Mountable 2012
Isometric and eccentric force generation assessment of skeletal muscles isolated from murine models of muscular dystrophies. Muscle Pathology & Wasting Dystrophy
1200A: Isolated Muscle System for Mice 2013
Neuromuscular Electrical Stimulation as a Method to Maximize the Beneficial Effects of Muscle Stem Cells Transplanted into Dystrophic Skeletal Muscle. Muscle Pathology & Wasting Dystrophy
1300A: 3-in-1 Whole Animal System for Mice 2013
Diaphragm muscle fiber weakness in pulmonary hypertension. Muscle Pathology & Wasting Cardiovascular
1200A: Isolated Muscle System for Mice 2011
Sustained release of bone morphogenetic protein-4 in adult rabbit extraocular muscle results in decreased force and muscle size: potential for strabismus treatment. Muscle Pathology & Wasting N/A
1205A: Isolated Muscle System for Rats 2011
Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice. Muscle Pathology & Wasting Sarcopenia
300C: Dual-Mode Muscle Levers 2011
Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model. Muscle Pathology & Wasting Myopathy
400C: Force Transducers 2011
In vivo canine muscle function assay. Muscle Pathology & Wasting Dystrophy
604A: Data Acquisition Signal Interface 2011
In vivo canine muscle function assay. Muscle Pathology & Wasting Dystrophy
890A: in-situ Large Animal Apparatus 2011
Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy. Muscle Pathology & Wasting DMD
615A: Dynamic Muscle Control and Analysis Software 2011
The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2- to 20-mo-old mdx mice. Muscle Pathology & Wasting DMD
615A: Dynamic Muscle Control and Analysis Software 2011
Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy. Muscle Pathology & Wasting DMD
701C: Electrical Stimulator 2011
Skeletal muscle weakness caused by carrageenan-induced inflammation. Muscle Pathology & Wasting Sarcopenia
1200A: Isolated Muscle System for Mice 2012
Single muscle fiber contractile properties in adults with muscular dystrophy treated with MYO‐029. Muscle Pathology & Wasting DMD
400C: Force Transducers 2009
Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice. Muscle Pathology & Wasting Atrophy
1200A: Isolated Muscle System for Mice 2010
Combination of myostatin pathway interference and dystrophin rescue enhances tetanic and specific force in dystrophic mdx mice. Muscle Pathology & Wasting DMD
300C: Dual-Mode Muscle Levers 2010
Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping. Muscle Pathology & Wasting Dystrophy
604A: Data Acquisition Signal Interface 2010
Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping. Muscle Pathology & Wasting Dystrophy
605A: Dynamic Muscle Data Acquisition and Analysis System 2010
Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury. Muscle Pathology & Wasting DMD
605A: Dynamic Muscle Data Acquisition and Analysis System 2005
Muscle fiber size and function in elderly humans: a longitudinal study. Muscle Pathology & Wasting Aging
400C: Force Transducers 2008
Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from mdx mice. Muscle Pathology & Wasting DMD
400C: Force Transducers 2008
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