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Muscle Physiology Applications2021-10-27T11:51:23-04:00

Muscle Physiology Applications

Aurora Scientific’s muscle physiology products are used in a variety of research protocols and assays to study skeletal, cardiac and smooth muscle from cell to whole tissue.  Whether in vivo, in vitro or in situ, physiologists can precisely measure various indices of function including force, length, and ratiometric calcium. They can also calculate important functional data such as twitch, tetanus, fatigue, force-frequency, force-velocity, stiffness and work loops, to name a few.

Popular basic science and preclinical applications of muscle physiology and function research are listed below.

Exercise & Metabolism

From studying how different athletes perform or recover to quantifying an animal model’s resistance to metabolic fatigue, the field of exercise and metabolic physiology encompasses a broad range of study. Aurora Scientific has solutions to address these different areas of inquiry whether in murine or other animal models, or even with human samples.  Powerful software combined with precise instruments for studying whole animal, whole muscle and single fiber samples make Aurora Scientific the leader in providing Exercise Physiologists with the means to understand muscle performance at the highest level.

Common Applications:

  • human performance
  • fatigue
  • injury rehabilitation
  • training & exercise

Cardiology

For nearly 20 years Aurora Scientific has been at the forefront of cardiac tissue mechanics research. Aurora Scientific equipment is used by many of the world’s top researchers studying isolated heart tissue, fibers and even cells. We understand that heart muscle is different from other types of muscle and that its study presents unique challenges. Whether measuring force in cardiac myocytes or quantifying the mechanical properties of iPSC-derived cardiac scaffolds, Aurora Scientific has the expertise and the instruments to support the most demanding of cardiac mechanics experiments.

Common Applications:

  • myosin thick & thin filaments
  • myofibrillar protein function
  • cardiac scaffolds & constructs
  • induced pluripotent stem cell (iPSC)-derived cardiac myocytes
  • cross-bridge cycling kinetics
  • artificial cardiac constructs
  • cardiac tissue engineering

Muscle Pathology & Wasting

As the largest generation in history enters their senior years, research into muscle pathologies has come into greater focus. These can include rare conditions like muscular dystrophy or more commonly, muscle atrophy due to cancer or disuse after injury. To develop drugs and therapies that combat this broad group of myopathies, functional measurements of muscle are often required in animal models. Aurora Scientific has worked with researchers in this community to provide tools that allow the study of muscles like the diaphragm as well as non-invasive assays to perform longitudinal tests on an individual animal as a disease or therapy progresses. We are proud of our long history working with the leading researchers and academics in this field and proud of the role our muscle pathology research instruments have played.

Common Applications:

  • Duchenne muscular dystrophy (DMD)
  • cachexia & sarcopenia
  • gerontology & aging
  • muscle atrophy
  • spinal muscular atrophy (SMA)
  • myotonia
  • glycogen storage disease type II (Pompe disease)
  • myotubular myopathy

Molecular Biology & Pharmacology

The study of animal models is one of the foundational pillars of molecular biology research. Aurora Scientific understands that your animal model is unique, and that characterizing its molecular phenotype can be challenging. It is important that the mechanism of drug action be understood in order to comprehend complex tissue responses. We have the solutions to study gross whole body physiology or the function of specific muscles to make characterizing the response of your animal model to pharmaceuticals both precise and efficient.

Common Applications:

  • knockout mouse function
  • signaling and transduction pathways
  • muscle regulatory proteins
  • stretch-activated channels

General Muscle Physiology

Aurora Scientific produces transducers specially designed for measuring force, velocity, sarcomere length and other contractile properties in muscle.  Integration with specially designed apparatus and software simplifies complex characterization of muscle properties. No matter what building block of muscle tissue you use as your model, from the myofibril to whole muscle groups and connective tissue, Aurora Scientific has a solution for you.

Common Applications:

  • muscle contractile properties
  • muscle architecture
  • muscle metabolism
  • fiber typing
  • mechanical properties of muscle

Comparative Muscle Physiology

The study of how living things move and are shaped by their environment often requires specialized tools and assays. Aurora Scientific has proven instruments engineered to the highest standards of accuracy and precision to uncover the diverse functional characteristics of muscle in your unique animal models. Measure complex muscle contractile properties from leeches, zebrafish and even cheetahs with our diverse, high-performance muscle physiology equipment.

Common Applications:

  • muscle energetics
  • muscle morphology
  • locomotion
  • bio-inspiration
  • invertebrate muscle
  • amphibian muscle
  • reptilian muscle
  • mammalian muscle

Explore Muscle Physiology Content

  • The schematic of the sensory innervations of mouse distal colon and rectum (colorectum) by lumbar splanchic and pelvic nerves.

Biomechanical Properties of GI Smooth Muscle

Image courtesy of Siri et al. (2019). Disorders like gastroparesis, gastroesophageal reflux disease (GERD), and inflammatory bowel syndrome (IBS) are very common causes of illness

  • Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic SCI

Treating Spinal-Muscle Conditions

Featured image courtesy of Bilchak et al. (2021). Spinal disruption can lead to serious conditions. Muscle-related issues can lead to spinal stiffness, pain or

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