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Muscle Physiology Applications2021-10-27T11:51:23-04:00

Muscle Physiology Applications

Aurora Scientific’s muscle physiology products are used in a variety of research protocols and assays to study skeletal, cardiac and smooth muscle from cell to whole tissue.  Whether in vivo, in vitro or in situ, physiologists can precisely measure various indices of function including force, length, and ratiometric calcium. They can also calculate important functional data such as twitch, tetanus, fatigue, force-frequency, force-velocity, stiffness and work loops, to name a few.

Popular basic science and preclinical applications of muscle physiology and function research are listed below.

Exercise & Metabolism

From studying how different athletes perform or recover to quantifying an animal model’s resistance to metabolic fatigue, the field of exercise and metabolic physiology encompasses a broad range of study. Aurora Scientific has solutions to address these different areas of inquiry whether in murine or other animal models, or even with human samples.  Powerful software combined with precise instruments for studying whole animal, whole muscle and single fiber samples make Aurora Scientific the leader in providing Exercise Physiologists with the means to understand muscle performance at the highest level.

Cardiology

For nearly 20 years Aurora Scientific has been at the forefront of cardiac tissue mechanics research. Aurora Scientific equipment is used by many of the world’s top researchers studying isolated heart tissue, fibers and even cells. We understand that heart muscle is different from other types of muscle and that its study presents unique challenges. Whether measuring force in cardiac myocytes or quantifying the mechanical properties of iPSC-derived cardiac scaffolds, Aurora Scientific has the expertise and the instruments to support the most demanding of cardiac mechanics experiments.

Muscle Pathology & Wasting

As the largest generation in history enters their senior years, research into muscle pathologies has come into greater focus. These can include rare conditions like muscular dystrophy or more commonly, muscle atrophy due to cancer or disuse after injury. To develop drugs and therapies that combat this broad group of myopathies, functional measurements of muscle are often required in animal models. Aurora Scientific has worked with researchers in this community to provide tools that allow the study of muscles like the diaphragm as well as non-invasive assays to perform longitudinal tests on an individual animal as a disease or therapy progresses. We are proud of our long history working with the leading researchers and academics in this field and proud of the role our muscle pathology research instruments have played.

Molecular Biology & Pharmacology

The study of animal models is one of the foundational pillars of molecular biology research. Aurora Scientific understands that your animal model is unique, and that characterizing its molecular phenotype can be challenging. It is important that the mechanism of drug action be understood in order to comprehend complex tissue responses. We have the solutions to study gross whole body physiology or the function of specific muscles to make characterizing the response of your animal model to pharmaceuticals both precise and efficient.

General Muscle Physiology

Aurora Scientific produces transducers specially designed for measuring force, velocity, sarcomere length and other contractile properties in muscle.  Integration with specially designed apparatus and software simplifies complex characterization of muscle properties. No matter what building block of muscle tissue you use as your model, from the myofibril to whole muscle groups and connective tissue, Aurora Scientific has a solution for you.

Comparative Muscle Physiology

The study of how living things move and are shaped by their environment often requires specialized tools and assays. Aurora Scientific has proven instruments engineered to the highest standards of accuracy and precision to uncover the diverse functional characteristics of muscle in your unique animal models. Measure complex muscle contractile properties from leeches, zebrafish and even cheetahs with our diverse, high-performance muscle physiology equipment.

Explore Muscle Physiology Content

  • Comparative Biology Using Animal Models

Comparative Biology Using Animal Models

Aurora Scientific provides instrumentation to aid in collecting and analyzing data in numerous comparative animal models highlighted in some recent publications in this review.

  • Designing an in-vivo study in DMC LabBookDesigning an in-vivo study in DMC LabBook

Designing an in-vivo study in DMC LabBook

This blog will provide a walkthrough of how to design a study in our Dynamic Muscle Control (DMC) LabBook software, specifically for 1300A 3-in-1 Whole Animal System in-vivo experiments.

  • Featured image (© 2021 Niosi et al., licensed under CC BY 4.0) represents microscopy image time lapse of a dissected midgut from a fruit fly undergoing mechanical testing.

Unique and Interesting Animal Models

At Aurora Scientific, we provide instrumentation to help assess muscle biomechanics in a variety of animal models from flies to octopuses, and highlight some recent examples in this publication review.

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