Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation. They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.
Strength training in older women: early and late changes in whole muscle and single cells.

Found 49 Results

Title	Research Area	Disease Model	System/Component	Year
Shortening the thick filament by partial deletion of titin’s C-zone alters cardiac function by reducing the operating sarcomere length range	Cardiology	N/A		2022
A high-whey-protein diet does not enhance mechanical and structural remodeling of cardiac muscle in response to aerobic exercise in rats	Cardiology	N/A		2022
Reduced cardiac muscle power with low ATP simulating heart failure	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2022
Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2022
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2021
Impact of syndecan-2-selected mesenchymal stromal cells on the early onset of diabetic cardiomyopathy in diabetic db/db mice	Cardiology	Diabetes	1600A: Permeabilized Myocyte System – Microscope Mountable	2021
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2021
Impact of syndecan-2-selected mesenchymal stromal cells on the early onset of diabetic cardiomyopathy in diabetic db/db mice	Cardiology	Diabetes	1600A: Permeabilized Myocyte System – Microscope Mountable	2021
In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2020
Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2020
Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2020
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2020
Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy	Cardiology	Myopathy	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2019
Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2019
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model	Cardiology	Diabetes	1600A: Permeabilized Myocyte System – Microscope Mountable	2019
Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2017
Myocardial relaxation is accelerated by fast stretch, not reduced afterload	Cardiology	Cardiovascular	315D/322D: High-Speed Length Controllers	2017
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes	Cardiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2018
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.	Cardiology	Myopathy	901D: High-Speed Video Sarcomere Length	2019
Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension.	Cardiology	Cardiovascular	901D: High-Speed Video Sarcomere Length	2018
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro.	Cardiology	Cardiovascular	600A: Real-Time Muscle Data Acquisition and Analysis System	2018
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro.	Cardiology	Cardiovascular	650A: Real-Time Muscle Data Acquisition and Analysis Software	2018
A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes.	Cardiology	Cardiovascular	901D: High-Speed Video Sarcomere Length	2017
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2014
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins	Cardiology	Myopathy	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.	Cardiology	Myopathy	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2014
Large-Scale Modulation of Titin Elasticity by S-Glutathionylation of Cryptic Cysteines.	Cardiology	Myopathy	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2014
Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2014
Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2014
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.”	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2014
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay.	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.	Cardiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.	Cardiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2014
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction.	Cardiology	Myopathy	801C: Small Intact Muscle Apparatus – Microscope Mountable	2013
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2013
Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2013
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.	Cardiology	Cardiovascular	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2013
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2013
Effects of alterations in sarcomere structure and prestretch timing on cardiac muscle mechanics.	Cardiology	Myopathy	1500A: Isolated Muscle System – Microscope Mountable	2012
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin.	Cardiology	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2013
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2013
Effect of aging on power output properties in rat skinned cardiac myocytes.	Cardiology	Aging	1600A: Permeabilized Myocyte System – Microscope Mountable	2011
Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices.	Cardiology	Cardiovascular	803B: Permeabilized Myocyte Apparatus – Microscope Mountable	2009
Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice.	Cardiology	Myopathy	315D/322D: High-Speed Length Controllers	2010
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.	Cardiology	Myopathy	400B: Force Transducers	2001
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C.	Cardiology	Myopathy	315D/322D: High-Speed Length Controllers	2007
Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae.	Cardiology	Myopathy	400B: Force Transducers	2008
Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices.	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2009

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