Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation.  They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Found 43 Results
Title Research Area Disease Model System/Component Year
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2021
Impact of syndecan-2-selected mesenchymal stromal cells on the early onset of diabetic cardiomyopathy in diabetic db/db mice Cardiology Diabetes
1600A: Permeabilized Myocyte System – Microscope Mountable 2021
In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes Cardiology Cardiovascular
1600A: Permeabilized Myocyte System – Microscope Mountable 2020
Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator Cardiology Cardiovascular
1600A: Permeabilized Myocyte System – Microscope Mountable 2020
Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2020
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2020
Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2019
Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy Cardiology Cardiovascular
1400A: Permeabilized Fiber System – Microscope Mountable 2019
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model Cardiology Diabetes
1600A: Permeabilized Myocyte System – Microscope Mountable 2019
Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2017
Myocardial relaxation is accelerated by fast stretch, not reduced afterload Cardiology Cardiovascular
315D/322D: High-Speed Length Controllers 2017
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes Cardiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2018
Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes. Cardiology Myopathy
901D: High-Speed Video Sarcomere Length 2019
Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension. Cardiology Cardiovascular
901D: High-Speed Video Sarcomere Length 2018
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Cardiology Cardiovascular
600A: Real-Time Muscle Data Acquisition and Analysis System 2018
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Cardiology Cardiovascular
650A: Real-Time Muscle Data Acquisition and Analysis Software 2018
A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes. Cardiology Cardiovascular
901D: High-Speed Video Sarcomere Length 2017
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work. Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2014
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay. Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2014
Large-Scale Modulation of Titin Elasticity by S-Glutathionylation of Cryptic Cysteines. Cardiology Myopathy
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2014
Automated analysis of contractile force and Ca2+ transients in engineered heart tissue. Cardiology Cardiovascular
1400A: Permeabilized Fiber System – Microscope Mountable 2014
Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone. Cardiology Cardiovascular
1400A: Permeabilized Fiber System – Microscope Mountable 2014
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.” Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2014
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay. Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2014
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins. Cardiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding. Cardiology Myopathy
1600A: Permeabilized Myocyte System – Microscope Mountable 2014
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction. Cardiology Myopathy
801C: Small Intact Muscle Apparatus – Microscope Mountable 2013
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue. Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2013
Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore. Cardiology Cardiovascular
801C: Small Intact Muscle Apparatus – Microscope Mountable 2013
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction. Cardiology Cardiovascular
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2013
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction. Cardiology Cardiovascular
1600A: Permeabilized Myocyte System – Microscope Mountable 2013
Effects of alterations in sarcomere structure and prestretch timing on cardiac muscle mechanics. Cardiology Myopathy
1500A: Isolated Muscle System – Microscope Mountable 2012
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin. Cardiology Myopathy
1400A: Permeabilized Fiber System – Microscope Mountable 2013
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue. Cardiology Cardiovascular
1500A: Isolated Muscle System – Microscope Mountable 2013
Effect of aging on power output properties in rat skinned cardiac myocytes. Cardiology Aging
1600A: Permeabilized Myocyte System – Microscope Mountable 2011
Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices. Cardiology Cardiovascular
803B: Permeabilized Myocyte Apparatus – Microscope Mountable 2009
Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice. Cardiology Myopathy
315D/322D: High-Speed Length Controllers 2010
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament. Cardiology Myopathy
400B: Force Transducers 2001
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Cardiology Myopathy
315D/322D: High-Speed Length Controllers 2007
Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculae. Cardiology Myopathy
400B: Force Transducers 2008
Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices. Cardiology Cardiovascular
1600A: Permeabilized Myocyte System – Microscope Mountable 2009
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