Americas: +1-877-878-4784 | Europe: +353-1-525-3300 | Asia: +852-3188-9946
Home|Posts|Exercise & Metabolism
  • MRHC Student Interviews

Excellence, Innovation, and Collaboration: Student Research at the MHRC

Cardiovascular, Interviews, Muscle Physiology, News, Videos|

This past April, we partnered with InsideScientific and the Muscle Health Research Centre (MHRC) at York University, a one-of-a-kind facility that fosters an interdisciplinary approach to the study of muscle physiology. We had the privilege of interviewing a number of faculty and students to highlight their research, as well as the opportunities provided to them by the MHRC.

  • Excellence, Innovation, and Collaboration: A Day at the MHRC with Arthur Cheng

Excellence, Innovation, and Collaboration: A Day at the MHRC with Arthur Cheng

Interviews, Muscle Physiology, News, Videos|

Interviewing Dr. Arthur Cheng at the Muscle Health Research Centre (MHRC), York University, an innovative research centre that facilitates the interdisciplinary study of muscle biology and the importance of skeletal muscle to the overall health and well-being of Canadians. Dr. Cheng's lab primarily investigates the mechanisms of skeletal muscle weakness and fatigue, and focuses on how calcium handling affects these mechanisms.

  • Excellence, Innovation, and Collaboration: A Day at the MHRC with Chris Perry

Excellence, Innovation, and Collaboration: A Day at the MHRC with Chris Perry

Interviews, Muscle Physiology, News, Videos|

Interviewing Dr. Christopher Perry at the Muscle Health Research Centre (MHRC), York University, an innovative research centre that facilitates the interdisciplinary study of muscle biology and the importance of skeletal muscle to the overall health and well-being of Canadians. Dr. Perry's lab studies metabolic dysregulation in murine models of muscle weakness disorders.

  • Talking Science with Chris Perry

Talking Real Science with Chris Perry

Interviews, Muscle Physiology, Videos|

Christopher Perry, PhD, an Associate Professor at York University with the School of Kinesiology & Health Science joined us to talk in detail about his career path that led him to study regulation of skeletal muscle metabolism. As a dedicated customer, Chris specifically highlights how the 1300A 3-in-1 Whole Animal System helps achieve his research goals.

Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasis

Gut microbiota influence the development of several chronic diseases including obesity, diabetes, and allergies. Recent studies suggest that an imbalance of gut microbiota may also influence muscle metabolism and contribute to muscle atrophy. This study focused on characterizing the impact of gut microbiota depletion on skeletal muscle by analyzing mice treated with gut-microbiota depleting antibiotics (ABT), mice treated with antibiotics followed by natural reseeding of microbiota (NAT), and control mice (CTL). Each group underwent running tests, where no differences were found in maximal aerobic velocity between each group. For the “Limit time to exhaustion during submaximal running test”, Tlim was significantly lower at day 9 than day 0 in both ATB and NAT mice. However, Tlim at day 19 was lower than day 0 in only the ATB group. Ex vivo contractile tests were then conducted using Aurora’s 305C Dual-Mode Muscle Lever and 701C High-Power Stimulator. EDL maximal strength was unaffected by the running tests; however, EDL muscle fatigue index was significantly reduced in ATB mice when compared with CTL and NAT mice. To investigate the role of gut microbiota on muscular glucose homeostasis, the authors analyzed markers linked to glucose metabolism in the gut-skeletal muscle. Levels of fasting-induced adipocyte factor (Fiaf) were significantly higher in the ATB group. In addition to this, free fatty acid receptor 3 (Gpr41) expression decreased. Following natural reseeding of the NAT group, increased levels of Gpr41 mRNA were observed when compared with the ABT group. Ileum muscle glycogen was also found to be significantly lower in ATB mice. These results highlight the interplay between gut microbiota and skeletal muscle. This study also provides insight into microbiome-based strategies for muscle therapy.

Recent Posts

Categories

Archives

Go to Top