Moving Mountains: Recent Feats in Muscle Physiology
As we March towards the 2024 American Physiology Summit, this month’s publication review covers recent advancements in the realm of muscle physiology, including the development of an improved resistance training method, the long-term musculoskeletal consequences of chemotherapy, and the characterization of crossbridge kinetics in cardiac trabeculae. Taken together, these studies reveal a promising trend of breakthroughs in muscle physiology.
Tackling the Heart of the Issue: Advances in Cardiovascular Research
February notably marks “Heart Month”, aiming to highlight the importance of cardiovascular health and its critical implications on our overall wellbeing. Tackling the heart of the issue, several cardiovascular studies stand out as key players within the preclinical research landscape. The following publication review covers recent advancements in the field, including a promising therapeutic drug candidate for heart failure as well as novel insights into the cardiovascular biology of Marfan syndrome and muscle contraction regulation.
Unlocking Heart Health: Revolutionizing Diastolic Function through Integrative Muscle Physiology at Wayne State University
Dr. Charles Chung is an Associate Professor of Physiology at Wayne State University. Using integrated physiology, analyzing data from the molecular level to the whole muscle, his laboratory aims to provide new directions and identify novel treatments for a variety of cardiac disorders. Learn more about his research group by watching the interview or summarized blog below.
Renewed Interests: Harnessing Engineered Constructs to Explore Novel Strategies in Regenerative Medicine
Tissue engineering is at the forefront of regenerative medicine, offering immense promise for restoring or enhancing the function of impaired tissues and organs. While tissue constructs remain costly in clinical settings, their use as a research tool holds vast potential for drug discovery, aiding and expediting the screening of drug candidates. In this publication review, we will discuss three recent publications leveraging specialized equipment from Aurora Scientific to advance the innovative field of engineered tissue constructs.
Cut and Paste of Myosin Binding Protein-C in Striated Muscles
Dr. Samantha Harris discusses the development of three new mouse models in her lab, engineered to target and replace specific myosin binding protein-C paralogs in muscle fibers and impact of their mutations on skeletal and cardiac muscle diseases.
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
Melissa Bukowski and colleagues describe and demonstrate a method to measure mechanical control of relaxation or the strain dependence of muscle relaxation in rodent cardiac trabecula.
Analyzing Cardiac Tissue Function
The following publication review showcases recent studies that use Aurora Scientific equipment to make advances in the field of biomechanics.
Excellence, Innovation, and Collaboration: Key Research at the MHRC
This past April, we partnered with InsideScientific and the Muscle Health Research Centre (MHRC) at York University, a one-of-a-kind facility that fosters an interdisciplinary approach to the study of muscle physiology. We interviewed three keystone researchers who are shaping the future of skeletal muscle health: David Hood, PhD, Peter Backx, PhD, and Ali Abdul-Sater, PhD.
Excellence, Innovation, and Collaboration: Student Research at the MHRC
This past April, we partnered with InsideScientific and the Muscle Health Research Centre (MHRC) at York University, a one-of-a-kind facility that fosters an interdisciplinary approach to the study of muscle physiology. We had the privilege of interviewing a number of faculty and students to highlight their research, as well as the opportunities provided to them by the MHRC.
Muscle Function in Diabetes and Heart Failure
This publication review takes a look at muscle function in the context of diabetes and heart failure, and how these mechanistic findings can help develop targeted therapies in the future.
Investigating a Novel Regulator of Atrial Contractility
Dr. David Barefield gives an in-depth discussion on his research investigating the role of the MyBP-HL protein in atrial dysfunction.
Cardiac Biophysics
Cardiac biophysics is a necessary component for understanding cardiac disease and dysfunction. This publication review explores recent publications that investigate mechanical and biophysical properties of cardiac muscle.