Renewed Interests: Harnessing Engineered Constructs to Explore Novel Strategies in Regenerative Medicine
Tissue engineering is at the forefront of regenerative medicine, offering immense promise for restoring or enhancing the function of impaired tissues and organs. While tissue constructs remain costly in clinical settings, their use as a research tool holds vast potential for drug discovery, aiding and expediting the screening of drug candidates. In this publication review, we will discuss three recent publications leveraging specialized equipment from Aurora Scientific to advance the innovative field of engineered tissue constructs.
Cancer Cachexia-Induced Muscle Atrophy
Cancer cachexia is a muscle wasting syndrome that is associated with certain cancers, but most commonly with advanced malignancies. This syndrome arises as a result of tumor-induced metabolic changes, causing the body to break down skeletal muscle and adipose tissue in response to nutritional deficiencies. These changes manifest as severe weight loss, anorexia, asthenia, and anemia, impairing the patient's capacity to tolerate infections, chemotherapy, and radiation treatments (Dhanapal et al., 2022). While research characterizing the multifactorial origins of this syndrome is still ongoing, three recent publications featuring our scientific equipment have made notable advances in the current understanding of this muscle wasting disease, and are discussed in this publication review.
Scents of Security: Emerging Olfaction Applications with Biorobots
The following publication review showcases several new and exciting findings in the olfactory sciences, highlighting how our instruments helped these researchers stir up the lab. The natural world often serves as inspiration for innovation, and insects – specifically their olfactory systems – have become a recent research topic of interest. Given the remarkable sensitivity of insect odor detection systems, the potential applications of this budding field are numerous.
Recent Therapeutic Advances in Duchenne Muscular Dystrophy (DMD) Models
The following publication review showcases recent studies focused on therapeutic advances in Duchenne Muscular Dystrophy (DMD) that use Aurora Scientific equipment.
Analyzing Cardiac Tissue Function
The following publication review showcases recent studies that use Aurora Scientific equipment to make advances in the field of biomechanics.
The Latest in Biomechanics
The following publication review showcases recent studies that use Aurora Scientific equipment to make advances in the field of biomechanics.
Exercise Science
Aurora Scientific equipment has played important roles in helping researchers understand muscle physiology under a variety of conditions in animal models as highlighted in this publication review.
Neuromuscular Junction and Muscle Pathophysiology
Thanks to Aurora Scientific equipment, numerous groups have been able to further expand our understanding of these pathologies and how we can improve muscle function. This publication review highlights some of the latest pathophysiological research that utilize our line of equipment.
Biophysics
The equipment needed to induce force, mount samples, and capture structural changes are among Aurora Scientific’s line of instrumentation and is highlighted in some recent publications in this review.
Comparative Biology Using Animal Models
Aurora Scientific provides instrumentation to aid in collecting and analyzing data in numerous comparative animal models highlighted in some recent publications in this review.
Unique and Interesting Animal Models
At Aurora Scientific, we provide instrumentation to help assess muscle biomechanics in a variety of animal models from flies to octopuses, and highlight some recent examples in this publication review.
Sensory Encoding by Muscle Spindle Afferents
This publication review highlights Aurora Scientific instruments that can facilitate the study of sensory encoding by muscle spindle afferents.
Muscle Function in Diabetes and Heart Failure
This publication review takes a look at muscle function in the context of diabetes and heart failure, and how these mechanistic findings can help develop targeted therapies in the future.
CNS Integration of Tactile Stimulation
Aurora Scientific offers instruments that facilitate the study of these primary sensory neurons, which have been highlighted in this publication review.
Neuronal Reorganization in Response to Odor
This publication review takes a look at two recent studies that examined the mouse olfactory bulb with help from Aurora Scientific olfaction instruments.
Attenuating Muscle Disease Pathology
This publication review discusses how Aurora Scientific muscle physiology products are used in muscular dystrophy preclinical research.
Mitochondrial Bioenergetics and Muscle Function
Highlighted in this publication review are systems available from Aurora Scientific that have aided studies of mitochondrial bioenergetics and muscle function in various research areas, including chronic kidney disease (CKD), sarcopenia, and chronopharmacology.
Myofilament Mechanics in Cardiac and Skeletal Muscle
This publication review highlights how Aurora Scientific offers technologies and instruments for facilitating mechanistic studies.
Modelling Exercise-Induced Muscular Changes Using Dynamic Contractions
This publication review highlights how some of our instruments have been used to study the morphological characteristics and function of muscle, as well as myocellular signaling, in rodent models of exercise.
Mitigating Neuromuscular Deficits
This publication review highlights how several researchers have recently employed our instruments and technologies to better understand these mechanisms and uncover new therapeutic avenues for a variety of diseases and disorders.
Cardiac Biophysics
Cardiac biophysics is a necessary component for understanding cardiac disease and dysfunction. This publication review explores recent publications that investigate mechanical and biophysical properties of cardiac muscle.
Best of 2021: Muscle Physiology
This publication review summarizes some of the best recent articles that fall under our Muscle Physiology category.
Best of 2021: Material Science
This publication review summarizes some of the best recent articles that fall under our Material Science category.
Best of 2021: Neuroscience – Olfaction and Somatosensation
Spatial arrangement of Ret+ and TrkB+ Meissner afferent cutaneous endings. Image courtesy of Neubarth et al., 2020.
Laryngeal Muscles in Development and Disease
Courtesy of Glass et al. (2019). The larynx is an organ that sits in the