Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation. They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.
Strength training in older women: early and late changes in whole muscle and single cells.

Found 22 Results

Title	Research Area	Disease Model	System/Component	Year
Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues	Artificial Muscle Physiological Tissue	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2023
Bioengineered 3D Skeletal Muscle Model Reveals Complement 4b as a Cell-Autonomous Mechanism of Impaired Regeneration with Aging	Artificial Muscle Physiological Tissue	Aging	1500A: Isolated Muscle System – Microscope Mountable	2023
ERRg agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation	Artificial Muscle Physiological Tissue	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2023
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2021
Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2022
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy	Muscle Pathology & Wasting	Myopathy	1500A: Isolated Muscle System – Microscope Mountable	2022
Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2021
Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction	Exercise & Metabolism	Obesity	1500A: Isolated Muscle System – Microscope Mountable	2020
Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A	Muscle Pathology & Wasting	Dystrophy	1500A: Isolated Muscle System – Microscope Mountable	2019
Incubation with sodium nitrite attenuates fatigue development in intact single mouse fibres at physiological	Exercise & Metabolism	N/A	1500A: Isolated Muscle System – Microscope Mountable	2019
Hypothermia Decreases O2 Cost for ex vivo Contraction in Mouse Skeletal Muscle	Exercise & Metabolism	N/A	1500A: Isolated Muscle System – Microscope Mountable	2018
Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy	General Physiology	Myopathy	1500A: Isolated Muscle System – Microscope Mountable	2018
Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice	Molecular Biology and Pharmacology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2018
Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2017
Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function.	Neuromuscular	Cancer	1500A: Isolated Muscle System – Microscope Mountable	2015
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay.	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2014
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.”	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2014
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.	Cardiology	Cardiovascular	1500A: Isolated Muscle System – Microscope Mountable	2013
Low Po2 conditions induce reactive oxygen species formation during contractions in single skeletal muscle fibers.	General Physiology	Aging	1500A: Isolated Muscle System – Microscope Mountable	2013
Effects of alterations in sarcomere structure and prestretch timing on cardiac muscle mechanics.	Cardiology	Myopathy	1500A: Isolated Muscle System – Microscope Mountable	2012
Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers.	Comparative Physiology	N/A	1500A: Isolated Muscle System – Microscope Mountable	2011
Effect of MicroRNA Modulation on Bioartificial Muscle Function.	Artificial Muscle Physiological Tissue	N/A	1500A: Isolated Muscle System – Microscope Mountable	2010

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