Industry Insights with Chris Rand from Aurora Scientific
Chris Rand, MSc, Sales and Marketing Manager, delves into the start and evolution of Aurora Scientific on this episode of #ShareScience, and our journey within the preclinical research world. He also discusses our path into the neuroscience space, and future directions the company is headed towards.
Neuronal Reorganization in Response to Odor
This publication review takes a look at two recent studies that examined the mouse olfactory bulb with help from Aurora Scientific olfaction instruments.
Best of 2021: Material Science
This publication review summarizes some of the best recent articles that fall under our Material Science category.
Best of 2021: Neuroscience – Olfaction and Somatosensation
Spatial arrangement of Ret+ and TrkB+ Meissner afferent cutaneous endings. Image courtesy of Neubarth et al., 2020.
How to Calibrate a 200B miniPID Using the Simple Gas Mixing Technique
The 200B miniPID is a fast response gas sensor commonly used in olfaction research as a validation tool to
Quantitative assessment of olfactory dysfunction accurately detects asymptomatic COVID-19 carriersaursc20dev
Coronavirus disease 2019 (COVID-19) is a disease caused by the SARS-CoV-2 virus. Although many people that contract COVID-19 remain asymptomatic, they may still transmit the virus. Therefore, it is important to identify these carriers to help prevent the spread of the disease. This study aimed to assess loss of smell and olfactory dysfunction in asymptomatic carriers, and to establish a precise method to quantify these parameters. The authors recorded detection in response to ten odorants at varying concentrations in normal healthy subjects and asymptomatic COVID-19 patients.
Olfactory and Neuromodulatory Signals Reverse Visual Object Avoidance to Approach in Drosophilaaursc20dev
Sensory plasticity in insects is mediated by behaviour-regulating biogenic amines. Some of these regulated behaviours include olfactory learning, aggression, and feeding. In Drosophila melanogaster, octopamine influences flight patterns and the response of motion-detecting neurons. This study analyzed both odor- and optogenetic-induced flight patterns using a flight simulator and odour delivery system. In addition to this, Aurora’s 200B miniPID sensor was used to at the beginning of each experiment to confirm air/odour at the location of the fly. In odourless air, it was found that the flies steered toward a vertical bar, which may mimic a plant stalk, but avoided a small box. It is thought that the small box may appear to be threatening but could also appear to be food. As such, they tested the animals’ response to each object in the presence of odours considered attractive to D. melanogaster. When Apple Cider Vinegar or ethanol odourant was added to the air, flies approached the small box that was previously avoided, and more strongly approached the vertical bar. However, in the presence of the odourant benzaldehyde, an odour that flies avoid, the flies displayed avoidance of the small object but continued to approach the vertical bar. These results suggest that visual valence reversal is produced by attractive odourants, but not aversive odourants. To elucidate how olfactory signals are coupled with behaviours, the authors tested whether aminergic neuromodulation was involved in odour-induced visual valence reversal. Transgenic flies expressing Chrimson, a red shifted excitatory channelrhodopsin, in aminergic neurons were subjected to stimulation by Chrimson-exciting illumination. Optogenetic depolarization of octopaminergic (OA) or tyraminergic (TA) neurons by the Tdc2-Gal4 driver changed the flight response to the small box from aversion to approach. Similar avoidance reversal was seen in 15/16 flies upon Tdc2 > Chrimson activation and in flies expressing Chrimson in T4 and T5 neurons. Taken together, this study provides insight into a model for multisensory processing in which attractive odors stimulate Tdc2 release, thus increasing response gain of the motion vision pathway.
Speed-Accuracy Tradeoff in Olfactionaursc20dev
Rinberg, Dmitry, Alex Koulakov, and Alan Gelperin developed a behavioral paradigm for mice in which both the duration of odorant sampling and the difficulty of the odor discrimination task were controlled. They observed that the accuracy of odor discrimination increases with the duration of imposed odorant sampling, and that the rate of this increase is slower for harder tasks.