Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation. They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.
Strength training in older women: early and late changes in whole muscle and single cells.

Found 20 Results

Title	Research Area	Disease Model	System/Component	Year
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy	Molecular Biology and Pharmacology	DMD		2023
Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies	Muscle Pathology & Wasting	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2022
Ultrastructural and kinetic evidence support that thick filaments slide through the Z-disc	General Physiology	N/A	1400A: Permeabilized Fiber System – Microscope Mountable	2022
Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes	Cardiology	N/A	1400A: Permeabilized Fiber System – Microscope Mountable	2023
Clinical and functional characterization of a long survivor congenital titinopathy patient with a novel metatranscript-only titin variant	Muscle Pathology & Wasting	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2023
Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging	Muscle Pathology & Wasting	Aging	1400A: Permeabilized Fiber System – Microscope Mountable	2022
Reduced cardiac muscle power with low ATP simulating heart failure	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2022
Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2019
Muscle weakness in a S. pneumoniae sepsis mouse model	Muscle Pathology & Wasting	Atrophy	1400A: Permeabilized Fiber System – Microscope Mountable	2019
Anterior cruciate ligament tear induces a sustained loss of muscle fiber force production	Orthopedics	Injury	1400A: Permeabilized Fiber System – Microscope Mountable	2018
Myosin filament sliding through the Z-disc relates striated muscle fibre structure to function	General Physiology	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2016
Cold acclimation increases cardiac myofilament function and ventricular pressure generation in trout.	Comparative Physiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2014
Alterations at the Cross-Bridge Level Are Associated with a Paradoxical Gain of Muscle Function In Vivo in a Mouse Model of Nemaline Myopathy.	Muscle Pathology & Wasting	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2014
Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2014
Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.	Cardiology	Cardiovascular	1400A: Permeabilized Fiber System – Microscope Mountable	2014
Force-Generation Capacity of Single Vastus Lateralis Muscle Fibers and Physical Function Decline With Age in African Green Vervet Monkeys.	Comparative Physiology	Aging	1400A: Permeabilized Fiber System – Microscope Mountable	2013
Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.	General Physiology	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2013
Lion (Panthera leo) and caracal (Caracal caracal) type IIx single muscle fibre force and power exceed that of trained humans.	Comparative Physiology	Sarcopenia	1400A: Permeabilized Fiber System – Microscope Mountable	2013
A gain-of-function mutation in the M-domain of cardiac myosin-binding protein-C increases binding to actin.	Cardiology	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2013
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.	General Physiology	Myopathy	1400A: Permeabilized Fiber System – Microscope Mountable	2008

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