1310A

3-in-1 Whole Animal System for Larger Rodents & Small Animals

This flexible test system delivers accurate measurement of large rodent/small animal muscle properties in-situ, in-vivo, and in-vitro. This is ideal for live animal protocols including injury and longitudinal studies, allowing researchers to evaluate the mechanical characteristics of intact muscle of large rodents, either isolated in-situ, with a footplate (ex-vivo) or isolated in-vitro.

Systems include: apparatus designed for large rodents/small animals, our flagship Dual-Mode muscle lever system, a high-power field/nerve stimulator, and data acquisition hardware and control and analysis software. The easy to use system allows experimental setup, data collection and data analysis to all be done in a matter of minutes.

By combining in-situ, in-vivo and in-vitro muscle testing on one simple platform, researchers are able to capture a complete picture of muscle physiology in large rodents. The 1310A comes with the large rodent apparatus, complete with temperature controlled animal and limb plates designed to support and fix the animal and limb being testing. In addition, the system can be converted to an isolated (in-vitro) muscle test system with the attachment of an optional 25 mL bath. Aurora Scientific’s flagship Dual-Mode lever system is also included, permitting measurement and control of both force and length.

Muscle samples are attached at only one point to measure force and length saving time and increasing productivity. The system includes our high-power, field/nerve stimulator and all required electrodes.

Control and analysis software comes pre-loaded on a custom PC. Experimental setup, data collection and data analysis can all be done in minutes with our control and analysis software (DMC/DMA). Parameters such as resting length, resting force, stimulation and the actual test protocol are all set using the control software. An extensive library of standard experimental protocols such as twitch, tetanus, fatigue, force-frequency, force-velocity, stiffness and work loops are also provided with the system.

805B
  • powerful 3-in-1 design: save time and space while increasing productivity
  • turn-key functionality
  • dual purpose field/nerve stimulator
  • ideal for live animal protocols: precision platform with temperature control
  • high experiment throughput
  • fast data acquisition and analysis software for Windows
  • simple to assemble, operate, and expand as your measurement needs change
  • capable of more complex multi-measurement protocols
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Tell the Whole Story – Live Animal & Isolated Tissue in One

The three system configurations allows the researcher to work with a broad range of muscle types and provide a convenient platform for compound screening, phenotype evaluation and comparison of murine models; all within one system.

High Throughput Software Capability

Experience high-throughput data analysis, including batch processing and multi-parameter calculations for hundreds of muscle samples within minutes. Downstream analysis can be completed within Aurora Scientific DMC/DMA software or exported to your analysis program of choice.

Standard Protocol Library

The protocol library includes a variety of muscle experiments for large rodent/small animal in vitro studies. Protocols include system operation and data acquisition settings optimized for sample type and measurement needs. Add your own custom protocols as well to streamline system operation with multiple lab members.

Stories of Success

1310A – A Custom Apparatus for Larger Animal Models

CHALLENGE

In 2011 Aurora Scientific was approached by Dr. Christopher Cardozo at the VA medical center to assist with researching the mechanisms of muscle atrophy in rats.  Dr. Cardozo planned to use in-situ methodology to test certain muscles of interest; however, his rat model was very large and he expected that they would produce large forces.  Aurora Scientific’s existing 1305A system and 806D platform could accommodate the measurement of forces up to 10N, which the animals were expected to well exceed.  Larger transducers existed but they were too big to fit on the existing 806D.

SOLUTION

Aurora Scientific had recently redesigned most of their in-situ apparatus and had spent a great deal of R&D time on building large animal apparatus.  As a result, Aurora Scientific had the experience and expertise to design a solution that would meet the needs of Dr. Cardozo and deliver at an affordable price.  A new apparatus was designed, more robust and easily able to withstand the higher forces and loads of large animals, yet still compatible with existing clamps and accessories for small animal use.

RESULTS

The Aurora Scientific solution worked well in Dr. Cardozo’s lab and provided an easy way for him to measure muscle force in large animals. He was able to collect large amounts of useful experimental data. The unit would later go on to find a minor niche for in-situ testing in lizards and also squirrels and other less conventional animal models. The redesign ultimately became the centerpiece of our 1310A complete system.

System Components

807B: in-situ Large Rodent/Small Animal Apparatus

807B: in-situ Large Rodent/Small Animal Apparatus

Easily test in situ muscle tissue dynamics in large rodents and other small animals

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300C: Dual-Mode Muscle Levers

300C: Dual-Mode Muscle Levers

Seamless, flexible control of force and length, with the unique ability to measure one or both in a single and convenient lever system.

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701C: Electrical Stimulator

701C: Electrical Stimulator

A single unit that combines all the instruments needed for accurate measurement of muscle properties in-situ, in-vivo and in-vitro.

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605A: Dynamic Muscle Data Acquisition and Analysis System

605A: Dynamic Muscle Data Acquisition and Analysis System

Precise, custom software designed for real-time data acquisition, instrument control and data analysis with unique, integrative features. Includes force and SL control capability

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608C-LCD Monitor

608C: LCD Monitor

A 22” widescreen LCD monitor providing high quality visualization of data collection

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Resources

Parts & Accessories

Model # 1310A
808-1 Vertical pin clamp that utilizes a 27G hypodermic needle to immobilize the mouse knee joint during in-situ experiments. It mounts on our family of 3-in -1 apparatus.
808-2 Vertical Screw Clamp that uses sharpened, stainless steel screws and a Delrin pad to fix mouse knee joint during in-situ experiments. It mounts on our family of 3-in-1 apparatus.
808-3 Upright knee clamp designed for rat that uses a horizontal stainless steel screw to restrain knee joint during in-vivo or in-situ experiments. It mounts on our family of 3-in-1 apparatus.
808-4 Upright knee clamp designed for rat that uses a dowel pin with a pad on the end for gentle immobilization of rat knee during in-vivo or in-situ experiments. It mounts on our family of 3-in-1 apparatus.
808-5 Upright knee clamp designed for mouse that uses a horizontal, sharpened stainless steel screw to prevent hind limb/joint movement during in-vivo or in-situ experiments. It mounts on our family of 3-in-1 apparatus.
808-6 Upright knee clamp designed for mouse that uses a horizontal dowel pin with pad for non-invasive knee restraint during in-vivo or in-situ experiments. It mounts on our family of 3-in-1 apparatus.
809C-25 Horizontal muscle bath which replaces the animal platform on 809C apparatus for in-vitro intact muscle mechanics experiments. The bath couples to the apparatus by removing the 4 screws for the limb platform and using them to attach the bath in its place. The volume of the bath is 25mL. Tools, tubing and fittings are also provided.
801-RES 1L reservoir assembly complete with built in, oxygenating bubbler. The reservoir is meant to supply oxygenated media to the 809C-25. The reservoir has an outer glass water jacket and can be connected to a circulating water reservoir to maintain perfusate temperature. Tubing and fittings to couple the reservoir are provided.
830A Half-rack adapter that allows half-rack instruments to be mounted in standard 19” racking. Works with models: 200B, 315C/322C, 400A series, 701C and 825A.
831A Heavy gauge, steel desktop or shelf-top rack, with standard 19” width for any Aurora Scientific Instruments. Available in various heights. (6U high for 1200A and 1300A, 5U high for 1400A, 1500A and 1600A systems).