1400A – Durable System Helps Researcher Study Thousands of Fibers
In 2004, Dr. Hans Degens was studying changes in skeletal muscle function and morphology. Dr. Degens was looking to use permeabilized fibers as his test samples as they represent a pure system for studying cross bridge mechanics without bias and artifacts. Dr. Degens was familiar with the experimental methodology of using skinned fibers but lacked the resources to build a system from scratch that could handle the higher throughput demands of testing human samples.
Aurora Scientific had recently released the 1400A system. This system featured an automatically indexing chamber enabling maximization of fiber throughput. The design also eliminated any manual bath movement, commonly found in designs at the time, thereby protecting the sensitive transducer from breakage. Dr. Degens’ system was also the first to feature peltier driven temperature control allowing for extremely stable and precise bath temperatures, critical to these measurements. The powerful 600A digital controller has allowed for nearly every experimental protocol conceived to be executed by the instruments themselves.
The system has been in nearly constant use in Dr. Degens’ lab for the last 11 years and has helped him collect data required for many influential and fascinating studies in exercise physiology, comparative biology and cardiovascular health, amongst countless others. This initial partnership with Aurora Scientific has led to other projects in whole muscle physiology as well.