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300C: Dual-Mode Muscle Levers

The 300C series of muscle levers are designed with unique specifications that allow the mechanical properties of a number of muscle types and sizes to be characterized.  Models are available for small force measurements up to 0.5N (e.g. mouse diaphragm strip or soleus) with a stunning resolution of 0.3mN (300C).  The range extends to the largest instrument with a maximum force measurement of 100N (e.g. dog hind limb) with a remarkable resolution of 10mN (310C-LR). The length signal resolution of all 7 lever systems is 1µm with a step change in length as fast as 1.3ms.

Designed for multiple configurations, researchers can utilize these muscle lever systems for in-vivo, in-situ, and in-vitro preparations. Additionally, the 300C series Dual-Mode levers provide the ability to control both force and length allowing measurement of a number of dynamic muscle properties.

The need for separate force and length systems is eliminated, providing a cost effective, accurate and easy to use solution for the muscle researcher.

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Footplate Variants:

Control and measure torque and angle for in-vivo mechanics of plantar and dorsi flexors.  All models listed are available in a footplate variant.

Indenter Variants:

300C – I: Mechanical Stimulator

305C – I: Mechanical Stimulator

2 Channel Dual-Mode Muscle Lever Variants:

300D-300-300: 2 Channel Dual-Mode Muscle Levers – both 300C
300D-300-305: 2 Channel Dual-Mode Muscle Levers – one 300C, one 305C
300D-305-305: 2 Channel Dual-Mode Muscle Levers – both 305C

  • evaluate simple to complex mechanical properties of skeletal, cardiac, and smooth muscle and connective tissue
  • accurate, reproducible output
  • dual-mode operation; control and measure both force and length
  • lacks transient errors when switching between force and length
  • levers for wide range of muscle force production (0.5N to 100N)
  • fast transient response
  • high resolution force and length
  • robust transducer with overload protection

300C Series Custom Modification Facilitates Genetic Therapy Research for Rare Myopathies

CHALLENGE

A group of researchers in North Carolina had several colonies of specially bred dogs as a model for muscular dystrophy and other rare myopathic disorders.  To test experimental therapies and learn about the disease progression, the researchers required an instrument to test whole animal muscle function.

300C – Dual-Mode Muscle Lever Enables Myonecrosis Research in Injured Muscle

CHALLENGE

Dr. Cliff Bayer has been studying myonecrosis induced by Group A streptococci (GAS) bacteria at V.A. Medical Center in Boise Idaho. Interestingly, this necrotizing infection develops in sites of muscle injury and is thought to be exacerbated by anti-inflammatory drugs (NSAIDs).

Models In The Series

300C - 0.5N Force, 10mm Excursion

Seamless, flexible control of force and length, with the unique ability to measure one or both in a single and convenient lever system

300C-LR - 1N Force, 10mm Excursion

Seamless, flexible control of force and length, with the unique ability to measure one or both in a single lever system designed for mice

305C - 5N Force, 20mm Excursion

Seamless, flexible control of force and length, with the unique ability to measure one or both in a single lever system designed for mice or rats

305C-LR - 10N Force, 20mm Excursion

Seamless, flexible control of force and length, with the unique ability to measure one or both in a single lever system designed for rats

309C - 20N Force, 30mm Excursion

Seamless, flexible control of muscle force and length, with the unique ability to measure one or both in adult rats

310C - 50N Force, 40mm Excursion

Seamless, flexible control of muscle force and length, with the unique ability to measure one or both in large rodents

310C-LR - 100N Force, 40mm Excursion

Seamless, flexible control of muscle force and length, with the unique ability to measure one or both in dogs, pigs and other small animals.