In 2013 Dr. George Christ, then of WFIRM, was studying links between gene expression and functional changes in muscle and other tissues.
He had previously been using other Aurora Scientific equipment to test the functional phenotype of various knock out and transgenic mice in his lab applying the in-vivo footplate technique. However, searching for small and subtle changes in muscle function between wild-type and transgenic animals could be wiped out with inconsistent experimental technique.
Shortly after his students began using the Aurora Scientific 806D for their rat studies, Matt visited Dr. Christ’s lab to demonstrate some of the finer points of the 806D apparatus. These included using the associated limb clamps for proper joint and limb fixation, proper electrode placement using high quality electrodes, and keeping the animal warm and consistently anesthetized over the course of the experiment. Implementation of these techniques helped Dr. Christ’s students gain comfort and proficiency with the experiments and techniques involved.
Dr. Christ is still using the equipment in his new lab at the University of Virginia and the equipment has been used to help him publish novel work in the field of biomaterials as they apply to regenerative medicine. Additionally, the techniques learned continue to be used by a future generation of graduate students keen to carry on this exciting research.