Dr. Young-Jin Son at Shriners Hospitals Pediatric Research Center studies peripheral nerve regeneration and the role Schwann cells play in maintaining and aiding regeneration of synaptic connections. Dr. Son was looking for a way to test functional recovery in mice with peripheral nerve injury in addition to measuring number of motor units and neuromuscular junction (NMJ) properties.
Dr. Son was well-versed in electrophysiological recordings, however, he wanted a way to test muscle function in response to regenerating sensory and motor afferents as well as determining the quality of re-innervation.
Due to the numerous parameters to be measured and different preparations required, Aurora Scientific knew the 809C apparatus would provide Dr. Son the configurability he needed. The 809C whole mouse apparatus combined with our flagship 300C Dual-Mode lever provided a cost effective way to quickly perform in-situ or in-vivo measurements in mice. Aurora Scientific also included our 809C-25 bath which attaches to the 809C apparatus to enable in-vitro measurement of nerve-muscle preparations.
With Aurora Scientific’s 3-in-1 system, Dr. Son has the ability to perform isometric muscle force measurement in mice, which is known to be an indicator of functional recovery in models of peripheral nerve regeneration. In addition, Dr. Son found great use of our in-situ configuration, which allows him to measure isometric force in specific muscles while maintaining vascular and neural connections. Furthermore, our in-vitro bath has allowed Dr. Son to use a nerve-muscle preparation to measure number of motor units as well as test NMJ properties in these models. The long term goal of his lab is to be able to perform longitudinal studies to measure functional recovery in-vivo in response to various treatment regimes. Aurora Scientific’s 1300A system provides the versatility that Dr. Son requires and will allow him to measure mechanical properties as his research progresses.