Women’s Health Month: Strides in Muscle Physiology
In honour of Women's Health Month, May’s publication review covers recent advances in female-focused muscle physiology research. These investigations into gradual ovarian failure, the impact of non-sugar sweeteners during the reproductive stage, and the effects of partial glycogen synthase kinase 3 knockdown, collectively advance our understanding of how sex differences can impact muscle physiology.
Spring into Action: Proteins of the Myofilament
In anticipation of the upcoming Myofilament Meeting, April’s publication review covers recent advances in the myofilament field. From the effects of inotropic agents on cardiac myofilament Ca2+ sensitivity, protein kinase D’s role in cardiac homeostasis, and the contribution of specific myosin-binding protein C domains in muscle contraction, the following studies usher in a promising trend of exciting breakthroughs.
Tackling the Heart of the Issue: Advances in Cardiovascular Research
February notably marks “Heart Month”, aiming to highlight the importance of cardiovascular health and its critical implications on our overall wellbeing. Tackling the heart of the issue, several cardiovascular studies stand out as key players within the preclinical research landscape. The following publication review covers recent advancements in the field, including a promising therapeutic drug candidate for heart failure as well as novel insights into the cardiovascular biology of Marfan syndrome and muscle contraction regulation.
Molecular Deep Dives in Force Production
As we launch full force into 2024, studies exploring the molecular underpinnings of force production in mice have blazed the trail of functional muscular research. From calcium dynamics during muscle contraction, to muscle impairments in myotonic dystrophy, and the effects of running on muscle mass in a dystrophic mouse model, January's novel insights into muscle function and regulation have important implications on our understanding of muscle physiology and health.
2024 Spring/Summer Scientific Conferences and Meetings
The Aurora Scientific team is continuing to journey out and connect with researchers at scientific conferences and meetings all over the world this spring and summer! We are particularly thrilled to be able to meet face-to-face with you all.
Anti-RANKL Therapy Prevents Glucocorticoid-Induced Bone Loss and Promotes Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy
Bisphosphonates are recommended to prevent bone loss in glucocorticoid-treated boys with Duchenne muscular dystrophy (DMD). This study explores the potential
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) results from the absence of dystrophin, leading to membrane injury and a breakdown of muscle fibers.
Unlocking Heart Health: Revolutionizing Diastolic Function through Integrative Muscle Physiology at Wayne State University
Dr. Charles Chung is an Associate Professor of Physiology at Wayne State University. Using integrated physiology, analyzing data from the molecular level to the whole muscle, his laboratory aims to provide new directions and identify novel treatments for a variety of cardiac disorders. Learn more about his research group by watching the interview or summarized blog below.
Best of 2023: Across Countries and Applications
2023 has proved to be a particularly fruitful year for scientific discovery, with a multitude of pioneering studies spanning continents and disciplines. From the intricate workings of muscle physiology in Switzerland to the nuanced understanding of migraine mechanisms in the USA, the discernment of mosquito olfactory processing in India, and the innovative strides in sustainable materials science in Germany and Austria, this year's research highlights embody the spirit of global collaboration and scientific ingenuity. We hope that, by highlighting the multitude of ways our instruments provide precise and reliable data, future and current researchers can draw inspiration for new and innovative ways to collaborate across borders.
Cut and Paste of Myosin Binding Protein-C in Striated Muscles
Dr. Samantha Harris discusses the development of three new mouse models in her lab, engineered to target and replace specific myosin binding protein-C paralogs in muscle fibers and impact of their mutations on skeletal and cardiac muscle diseases.
Integrating Patient Engagement and Trainee Development in Pre-Clinical Research
Christopher Perry, PhD discusses how his laboratory aims to discover mechanisms by which metabolic dysfunction causes muscle weakness and apply these findings to develop new therapies for muscle disorders. Homira Osman, PhD will provide a particular focus on leveraging scientific findings for practice and policy and linking trainees with patient communities.
Exercise Science
Aurora Scientific equipment has played important roles in helping researchers understand muscle physiology under a variety of conditions in animal models as highlighted in this publication review.
Excellence, Innovation, and Collaboration: Key Research at the MHRC
This past April, we partnered with InsideScientific and the Muscle Health Research Centre (MHRC) at York University, a one-of-a-kind facility that fosters an interdisciplinary approach to the study of muscle physiology. We interviewed three keystone researchers who are shaping the future of skeletal muscle health: David Hood, PhD, Peter Backx, PhD, and Ali Abdul-Sater, PhD.
Excellence, Innovation, and Collaboration: Student Research at the MHRC
This past April, we partnered with InsideScientific and the Muscle Health Research Centre (MHRC) at York University, a one-of-a-kind facility that fosters an interdisciplinary approach to the study of muscle physiology. We had the privilege of interviewing a number of faculty and students to highlight their research, as well as the opportunities provided to them by the MHRC.
Functional Recovery of the Musculoskeletal System Following Injury – Leveraging the Large Animal Model
Watch Dr. Sarah Greising discuss the current pathophysiologic understanding of the skeletal muscle remaining following traumatic musculoskeletal injuries.
Excellence, Innovation, and Collaboration: A Day at the MHRC with Arthur Cheng
Interviewing Dr. Arthur Cheng at the Muscle Health Research Centre (MHRC), York University, an innovative research centre that facilitates the interdisciplinary study of muscle biology and the importance of skeletal muscle to the overall health and well-being of Canadians. Dr. Cheng's lab primarily investigates the mechanisms of skeletal muscle weakness and fatigue, and focuses on how calcium handling affects these mechanisms.
Muscle Function in Diabetes and Heart Failure
This publication review takes a look at muscle function in the context of diabetes and heart failure, and how these mechanistic findings can help develop targeted therapies in the future.
Attenuating Muscle Disease Pathology
This publication review discusses how Aurora Scientific muscle physiology products are used in muscular dystrophy preclinical research.
Best of 2021: Muscle Physiology
This publication review summarizes some of the best recent articles that fall under our Muscle Physiology category.