Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation. They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Oxidative stress-induced dysregulation of excitation–contraction coupling contributes to muscle weakness
Acid-Sensing Ion Channels Drive the Generation of Tactile Impulses in Merkel Cell–Neurite Complexes of the Glabrous Skin of Rodent Hindpaws
The giant protein titin regulates the length of the striated muscle thick filament.

Found 15 Results

Title	Research Area	Model	Product	Year
The carbon monoxide prodrug oCOm-21 increases Ca2+ sensitivity of the cardiac myofilament	General Physiology	N/A	1600A: Permeabilized Myocyte System – Microscope Mountable	2024
Protein Kinase D plays a crucial role in maintaining cardiac homeostasis by regulating post-translational modifications of myofilament proteins	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2024
Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads	General Physiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2024
Impact of syndecan-2-selected mesenchymal stromal cells on the early onset of diabetic cardiomyopathy in diabetic db/db mice	Cardiology	Diabetes	1600A: Permeabilized Myocyte System – Microscope Mountable	2021
Impact of syndecan-2-selected mesenchymal stromal cells on the early onset of diabetic cardiomyopathy in diabetic db/db mice	Cardiology	Diabetes	1600A: Permeabilized Myocyte System – Microscope Mountable	2021
In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2020
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues	General Physiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2020
Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2020
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model	Cardiology	Diabetes	1600A: Permeabilized Myocyte System – Microscope Mountable	2019
Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes	Cardiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2018
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.	Cardiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2014
S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding.	Cardiology	Myopathy	1600A: Permeabilized Myocyte System – Microscope Mountable	2014
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction.	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2013
Effect of aging on power output properties in rat skinned cardiac myocytes.	Cardiology	Aging	1600A: Permeabilized Myocyte System – Microscope Mountable	2011
Fabrication and evaluation of reconstructed cardiac tissue and its application to bio-actuated microdevices.	Cardiology	Cardiovascular	1600A: Permeabilized Myocyte System – Microscope Mountable	2009

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