Microdystrophin Gene Addition Significantly Improves Muscle Functionality and Diaphragm Muscle Histopathology in a Fibrotic Mouse Model of Duchenne Muscular Dystrophy
This study investigates the effectiveness of adeno-associated viral (AAV) vector-mediated microdystrophin gene addition therapy in a fibrotic mouse model of
Anti-RANKL Therapy Prevents Glucocorticoid-Induced Bone Loss and Promotes Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy
Bisphosphonates are recommended to prevent bone loss in glucocorticoid-treated boys with Duchenne muscular dystrophy (DMD). This study explores the potential
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) results from the absence of dystrophin, leading to membrane injury and a breakdown of muscle fibers.
Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues
This study utilizes human pluripotent stem cell (hPSC)-derived cardiomyocytes to explore ischemic heart failures. While previous studies demonstrate the potential
Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9
Thürkauf et al. establish an efficient CRISPR/Cas9 genome editing system for targeted, multiplexable gene knockouts in skeletal muscle fibers of
The cellular basis of mechanosensation in mammalian tongue
In this study, in-vivo calcium imaging of mouse trigeminal ganglion neurons is employed to identify functional groups of mechanosensory neurons
Combinatorial encoding of odors in the mosquito antennal lobe
This study focuses on how mosquitoes encode individual odourants from host smells in their brain. Using an in-vivo preparation for