605A: Dynamic Muscle Data Acquisition and Analysis System
The 605A Data Acquisition and Analysis System provides physiology researchers with a complete hardware and software package for obtaining and processing data from Aurora Scientific instrumentation. The 605A system includes our LabVIEW based Windows software suite consisting of Dynamic Muscle Control (DMC) and Dynamic Muscle Analysis – High Throughput (DMA-HT) in addition to a Windows PC, National Instruments A/D card and our 604A signal interface.
Our DMC protocol library includes a variety of muscle experiments for mouse and rat mechanics which include system operation and data acquisition settings optimized for the researchers unique sample type and measurement needs. You can add your own custom protocols to suit the needs of multiple lab members.
Experience high-throughput data analysis with DMA-HT to process hundreds of muscle samples in minutes. Downstream analysis can be completed within Aurora Scientific’s DMC/DMA software or exported to your preferred analysis program. The software comes pre-loaded on a quad core Windows PC installed with a National Instruments A/D card. Easily connect Aurora Scientific transducers, motors, levers and stimulators to your PC with our signal interface which comes complete with BNC cables, terminators and T-fitting.
Components
601A: Windows PC
603C: 16-bit Data Acquisition Card
604A: Signal Interface
615A: Dynamic Muscle Data Acquisition and Analysis Software
Parts & Accessories
606A: BNC-BNC Cable
607A: BNC Terminator
607B: BNC T
615B: DMC/DMA-HT Suite 2nd Copy
615C: DMC/DMA-HT Suite Upgrade
608C: Monitor, 22″ Widescreen LCD
Select References
- Magill, Christina K. et al. “The differential effects of pathway-versus target-derived glial cell line-derived neurotrophic factor on peripheral nerve regeneration.” The Journal of Neurosurgery (2010) DOI: 10.3171/2009.10.JNS091092
- Goyenvalle, Aurélie et al. “Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping.” Molecular Therapy (2010) DOI: 10.1038/mt.2009.248
- Li, Dejia and Dongsheng Duan. “Mitochondria-targeted antiaging gene therapy with adeno-associated viral vectors.” Methods in Molecular Biology (2013) DOI: 10.1007/978-1-62703-556-9_13
- Holwerda, Andrew M. and Marius Locke. “Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions.” Applied Physiology, Nutrition and Metabolism (2014) DOI: 10.1139/apnm-2014-0118
- Hakim, Chady H., Nalinda B. Wasala and Dongsheng Duan. “Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice.” Journal of Visualized Experiments (2013) DOI: 10.3791/50183
- Tupling, A. Russell et al. “Effects of buthionine sulfoximine treatment on diaphragm contractility and SR Ca2+ pump function in rats.” Journal of Applied Physiology (2007) DOI: 10.1152/japplphysiol.00529.2007
- Graber, Ted G. et al. “C57BL/6 neuromuscular healthspan scoring system.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences (2013) DOI: 10.1093/gerona/glt032
- Liu, Mingju et al “Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury.” Molecular Therapy (2005) DOI: 10.1016/j.ymthe.2004.09.013
- Segales et al. “Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals” Nature communications (2020) DOI: 10.1038/s41467-019-13832-9
- Gorini et al. “Reversible temporally-specific inhibition of muscle using a light-activated chloride channel” bioRxiv (2018) DOI: 10.1101/398156
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| System Specifications | 605A |
|---|---|
| Instruments Included in System | 601A – PC with 64-bit Windows 7 603C – 16-bit Data Acquisition Card 604A – Signal Interface 615A – Dynamic Muscle Control and Analysis Software |
| Aurora Scientific Instruments Controlled |
300 series length controllers, 400 series force transducers, 700 series stimulators, 800 series apparatus |
| 601A PC Specifications | 605A |
|---|---|
| Processor [GHz] | 3.3, 6 cores |
| RAM [GB] | 8 |
| Hard Disk [TB] | 1 |
| DVD ROM | DVD-R, CD-R |
| 603C Data Acquisition Specifications | 605A |
|---|---|
| Analog Input | Number of Channels: 8 Resolution: 16 bits Sampling Rate: 250,000 samples per second |
| Analog Output | Number of Channels: 2 Resolution: 16 bits Sampling Rate: 833,000 updates per second |
| Digital I/O | Number of Ports: 61 Type: TTL |
1 = 6 available on 604A Signal Interface, 24 available on data acquisition card
| 604A Signal Interface Specifications | 605A |
|---|---|
| Connector | BNC – isolated, male |
| A/D Inputs | 8: Length In, Force In, Aux 1-6 In |
| A/D Outputs | 2: Length Out, Force Out |
| Digital I/O | 6 total: 2 Inputs: Trg In 1, Trg In 2, 4 Outputs: Trg Out 1, Trg Out 2, Stimulator, Inhibit |
| 615A Software Specifications | 605A |
|---|---|
| Operating System | Windows XP/Vista/7/8/10 |
| Included Software | 610A – Dynamic Muscle Control LabBook 611A – Dynamic Muscle Analysis 612A – Dynamic Muscle Analysis – High Throughput |
| 610A DMC LabBook Specifications | 605A |
|---|---|
| Data Channels Recorded | Length, Force, Stimulation Timing, Auxiliary 1-62 |
| Main Window | Controls: Change Study, Change Animal, Sample, Prepare Experiment, Run Experiment, Analyze Results, Edit Sample Parms, View, Prev, Next, Readout 1 Select, Readout 2 Select, Reset Timer Readouts: 1 and 23, Elapsed Time, Time since Last Test, Experiment Run Counter Dropdown menus: File, Setup and Help |
| Study Window | Used to define a study Text Entry Fields: Name of Study, Description of Study, Animal Parameter definition and selection, Sample Parameter definition and selection, Muscles in Study definition and Selection, Experiments in Study definition and selection |
| Select Experiment Window | Select experiments to use in a study and create new experiments Existing Experiment list and selection button Create New Experiment: 6 wizards to create the following experiments: Twitch, Tetanus, Fatigue, Force-Frequency, Eccentric, Injury Custom Experiment button: opens protocol editor to allow creation of a custom experiment |
| Live Data Monitor | Real-time data output of chosen channels. Displays up to 30 minutes of data – zoom function, time base control, graph scales, freeze display |
| Prepare Experiment Window | Used to prepare the muscle for the test. Instant Stim control, Display of Twitch Force, Overlay of successive twitches, Calculation of Baseline Force and Max Force. |
| Analysis4 | Load last data or saved data Display: Length, Force, Stimulation Plot Zoom Controls: Time Displayed and Offset sliders, Unzoom Calculated Values: Max Force, Time of Max Force, Min Force, Time of Min Force, Force at Time Zero, Max Length, Time of Max Length, Min Length, Time of Min Length, Length at Time Zero |
2 = Auxiliary Channels: can be configured to suit, common usages are: Temperature, pH, O2, etc.; 3 = Configured using Readout Select 1 and 2, normally displays Force In and Length In; 4 = Limited analysis available in 610A program, complete Analysis available in 611A and 612A programs
| 611A/612A DMA/DMA-HT Specifications | 605A |
|---|---|
| Main Window | Display: graph of test results with zoom function Plot Controls: Unfiltered/Filtered Force, Unfiltered/Filtered Length, Force Units, Length Units Buttons for: Invert Force Data, Open Data File, Filter Setup, Normalization, Muscle Analysis, Work Loop, Time Derivative, Line Fitting, Export Data Dropdown menus: File, High Throughput and Help |
| Analysis | Filter Setup: set cutoff frequency and order of Butterworth low-pass filter Normalization: set reference values for calculating L/Lref, F/Fref, Stress, Strain Muscle Analysis: provides statistics of displayed data Work Loop: calculates work loop data from sinusoidal tests Time Derivative: calculates velocity and dF/dt Line Fitting: fits linear or exponential functions to Force and Length data |
| High Throughput Analysis | Provides high speed analysis of a group of data files, data is output in tabular form and can be exported Analysis Types: Force-Frequency, Force-Time, Position-Time, Fatigue Calculated Values: Maximum, Minimum, Time to % Contraction, Time to % Relaxation, Integration, Max Rate of Contraction, Time to % of Max Rate of Contraction, Max Rate of Relaxation, Time to % of Max Rate of Relaxation, Starting Baseline, Ending Baseline, Average Rate of Contraction, Average Rate of Relaxation |
| Export Analysis | Exports analysis to: Excel, MATLAB, Maple, SAS, other software packages |