490A: Torque Transducer
The 490A series of isometric torque transducers are a series of rotational load cells that are designed primarily to enable in-vivo contractile measurements made across the joints of various animal models. The 490A is an excellent choice for basic isometric measurements such as twitch, tetanus, force-frequency and fatigue when cost or throughput is a major consideration. Each torque transducer model is capable of measuring applied torque in both clockwise and anti-clockwise directions. The torque sensor heads are exceptionally durable, yet still offer the same low compliance and sensitivity as our motorized 300 series.
There are six models in the series with the most sensitive model featuring a resolution of 0.005mN-m, and the largest model having a maximum torque threshold of 100N-m. The range of sensor heads allows researchers to measure limb torque from mice up to animals as large as dogs and swine, among others. Sensor heads will mount interchangeably on all models of apparatus designed for in-vivo measurements (809/806/807/890). Each sensor is compatible with the same controller, which allows researchers to easily substitute in an appropriate sensor head for the animal model being measured.
Models
A series of rotational load cells that enable in-vivo contractile measurements made across the joints of a variety of animal models
490A: 35mN-m
491A: 350mN-m
492A: 700mN-m
493A: 7,000mN-m
494A: 50,000mN-m
Variants
Available Sensor Heads:
490A-HD: 35mN-m
491A-HD: 350mN-m
492A-HD: 700mN-m
493A-HD: 7,000mN-m
494A-HD: 50,000mN-m
Select References
- Al-Sajee, Dhuha et al. “Xin-deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality.” Acta Physiologica (2015) DOI: 10.1111/apha.12455
- Maino et al. “Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression” EMBO Molecular Medicine (2021) DOI: 10.15252/emmm.202013228
- Maino et al. “Targeted genome editing in vivo corrects a Dmd duplication restoring wild-type dystrophin expression” EMBO Molecular Medicine (2021) DOI: 10.15252/emmm.202013228
- Lonh et al. “Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy” Human Molecular Genetics (2019) DOI: 10.1093/hmg/ddy382
- VanderVeen et al. “Skeletal muscle function during the progression of cancer cachexia in the male ApcMin/+ mouse” The Journal of Applied Physiology (2018) DOI: 10.1152/japplphysiol.00897.2017
- McClenaghan et al. “Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS” EMBO Molecular Medicine (2023) DOI: 10.15252/emmm.202216883
- Rooney, Jachinta and Rich Lovering “Single muscle contractile measurements in vivo and in situ.” NIH (2015) DOI: N/A
- Alway, Stephen E. and Robert G. Cutlip “Resistance Loading and Signaling Assays for Oxidative Stress in Rodent Skeletal Muscle.” Methods in Molecular Biology Myogenesis (2011) DOI: 10.1007/978-1-61779-343-1_11
- Gallot et al. “PERK regulates skeletal muscle mass and contractile function in adult mice” The FASEB Journal (2019) DOI: 10.1096/fj.201800683RR
- Leduc et al. “Parkin overexpression protects from ageing-related loss of muscle mass and strength” The Journal of Physiology (2019) DOI: 10.1113/JP277157
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Learn MoreSpecifications
Torque Specifications | 490A | 491A | 492A | 493A | 494A |
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COMING SOON! |
General Specifications | 490A | 491A | 492A | 493A | 494A |
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COMING SOON! |