890A: in-situ Large Animal Apparatus

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The 890A Large Animal Test Apparatus and its variants (891A and 892A) enable physiology researchers to test and measure muscle responses in the hind limbs of dogs, sheep, swine and larger animals in-situ or in-vivo.

This apparatus is available in three configurations: isometric (890A and 892A) and isometric/isotonic (891A). The isometric configurations measure force-frequency and muscle fatigue, while isometric/isotonic measures force-frequency, fatigue, eccentric contractions, force-length, force-velocity, work and stiffness.

The apparatus provides accurate limb fixation, an animal footplate, a force sensor and/or motor and linear translators to adjust the footplate position with respect to the animal’s limb. It can be used with either hind limb.

The tri-axis positioner allows easy alignment of the footplate with respect to the animal and fine motor movement to adjust resting length or resting tension. The 890A or 892A apparatus come complete with a torque cell while the 891A is designed for use with a 309C or 310C Dual-Mode muscle lever (purchased separately).

apparatus designed to test in-vivo/in-situ muscle mechanics in large animals such as swine, dogs and sheep
flexible limb clamping, easily adjust location of clamp with respect to the animal’s hind limb
ability to test both hind limbs with ease, increase throughput
tri-axis positioner provides easy positioning of the footplate with respect to the animal

available in three configurations, isometric for simple mechanics (890A for dogs, 892A for swine) and isometric/isotonic for more complex protocols
fine translation stage on sensor allows accurate setting of resting tension
T-slot design provides flexibility to easily add additional apparatus and corrosion resistant materials used throughout
robust design

Variants

Large Animal Isometric/Eccentric Footplate Apparatus Variants:

891A Large Animal Footplate Test Apparatus: 309C/310C – Measure force-frequency, fatigue, eccentric contractions, force-length, force-velocity, work and stiffness with the addition of a 309C/310C Dual-Mode muscle lever

892A Swine Isometric Footplate Test Apparatus: Easily test in-vivo muscle tissue mechanics in swine and other large animals

Select References

Corona et al. “Pharmacological Mitigation of Fibrosis in a Porcine Model of Volumetric Muscle Loss Injury” Tissue Engineering Part A (2020) DOI: 10.1089/ten.TEA.2019.0272
Kheirabadi, Bijan S. et al “Long-term effects of Combat Ready Clamp application to control junctional hemorrhage in swine.” The Journal of Trauma and Acute Care Surgery (2014) DOI: 10.1097/TA.0000000000000350
Childers, Martin K., Robert W. Grange and Joe N. Kornegay “In vivo canine muscle function assay.” Journal of Visualized Experiments (2011) DOI: 10.3791/2623
Segales et al. “Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals” Nature communications (2020) DOI: 10.1038/s41467-019-13832-9
Gorini et al. “Reversible temporally-specific inhibition of muscle using a light-activated chloride channel” bioRxiv (2018) DOI: 10.1101/398156
Cosentino et al. “Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia” Scientific Reports (2023) DOI: 10.1038/s41598-023-37553-8
Llewellyn, Michael E. et al. “Orderly recruitment of motor units under optical control in vivo.” Nature Medicine (2010) DOI: 10.1038/nm.2228
Ma et al. “Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle” Internation Journal of Molecular Sciences (2018) DOI: 10.3390/ijms19092643
Hamoudi et al. “Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice” Human Molecular Genetics (2020) DOI: 10.1093/hmg/ddz312
Zhao et al. “Meningeal P2X7 Signaling Mediates Migraine-Related Intracranial Mechanical Hypersensitivity” The Journal of Neuroscience (2023) DOI: 10.1523/JNEUROSCI.0368-23.2023

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Specifications

Apparatus	890A	891A	892A
Thigh Cuff X Axis Movement [mm]	345	345	380
Thigh Cuff Y Tube Movement [mm]	298	298	410
Thigh Cuff Z Axis Movement [mm]	164	164	155
Footplate X Axis Stage Movement [mm]	220	220	220
Footplate Y Axis Stage Movement [mm]	220	220	220
Footplate Z Axis Stage Movement [mm]	220	220	220
Footplate Rotary Movement [degrees]	360	NA	360
XYZ Stage Mount Plate Y Movement [mm]	195	195	195
Stage Travel/Hand wheel Revolution XYZ [mm]	3	3	3
Weight [kg]	25	25	24
Dimensions [cm]	48W x 93L x 66H

Torque Transducer and Controller	890A	891A	892A
Maximum Torque [+N-m]	50	NA	50
Resolution [mN-m]	2	NA	2
Scale Factor [N-m/Volt + 2%]	5	NA	5
Bandwidth [Hz¹]	300	NA	300
Risetime [ms²]	1.2	NA	1.2
Zero Drift [mV/°C]	0.2	NA	0.2
Non-linearity [±% Full Scale]	0.2	NA	0.2
Hysteresis [±% Full Scale]	0.2	NA	0.2
Non-repeatability [±% Full Scale]	0.05	NA	0.05
Offset Knob Adjustment Range [±mV]	50	NA	50
Gain Switch Ranges	x1, x5, x10	NA	x1, x5, x10
Safe Overload [±N-m]	75	NA	75
Connection³	4-pin Plug	NA	4-pin Plug

1 = at -3dB point; 2 = 10-90%; 3 = Connector Part Number: Lemo FGG.0B.304.CLAD52

General Specifications	890A	891A	892A
Operating Temperature [°C]	0-40	NA	0-40
Power Required	100-240 VAC, 50/60 Hz. available	NA	100-240 VAC, 50/60 Hz. available
Power Consumption [W]	20	NA	20
Controller Weight [kg]	2.5	NA	2.5
Sensor Weight [g]	250	NA	2.5
Dimensions [cm]	21W (1/2 rack mount) x 25D x 9H (2U)	NA	21W (1/2 rack mount) x 25D x 9H (2U)