Publications

The following is a collection of select publications referencing Aurora Scientific instrumentation. They serve as excellent examples regarding system capabilities, common research applications, methodology and best-practices.

Use the filters and settings to identify publications of interest by research application and associated Aurora Scientific system or component used.

Featured Publications

Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.
Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament.
Strength training in older women: early and late changes in whole muscle and single cells.

Found 10 Results

Title	Research Area	Disease Model	System/Component	Year
Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2020
Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2020
Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity	Exercise & Metabolism	Atrophy	801C: Small Intact Muscle Apparatus – Microscope Mountable	2019
Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function.	Neuromuscular	Cancer	801C: Small Intact Muscle Apparatus – Microscope Mountable	2015
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.	Muscle Pathology & Wasting	Myopathy	801C: Small Intact Muscle Apparatus – Microscope Mountable	2015
Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2014
Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2014
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction.	Cardiology	Myopathy	801C: Small Intact Muscle Apparatus – Microscope Mountable	2013
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2013
Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore.	Cardiology	Cardiovascular	801C: Small Intact Muscle Apparatus – Microscope Mountable	2013

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