There is a new version of this product available. Check out the 800C: in-vitro Muscle Apparatus!
800A/805A: in-vitro Muscle Apparatus
The 800A (mouse) and 805A (rat) in-vitro muscle apparatus are designed for use with our 300C and 305C Dual-Mode muscle levers, respectively. Flexible in design, these test systems allow vertical, in-vitro measurement of intact muscle in a tissue bath.
The bath is mounted to a vertical translation stage, allowing the researcher to raise and lower the bath for easy access to the tissue during mounting, removal and measurement. The bath is temperature controlled and accompanied by an oxygenating bubbler system. Dual fine/coarse controls permit accurate positioning of the tissue and adjustments of resting tension or muscle length.
For the researcher’s convenience, T-slots on the mounting panel allow all clamps to be rearranged as needed. Likewise, additional instrumentation can be easily added to the mounting panel. Designed for long life, the apparatus is made of corrosion resistant materials, with attention paid to details such as potted electrodes to prevent corrosion.
Variants
800B Dual-Bath in-vitro Muscle Apparatus For Mouse:
Test both mouse hind limbs simultaneously with two 300C Dual-Mode muscle levers
805B Dual-Bath in-vitro Muscle Apparatus For Rat:
Test both rat hind limbs simultaneously with two 305C Dual-Mode muscle levers
Select References
- Anderson, Christopher V. et al. “Thermal effects on the performance, motor control and muscle dynamics of ballistic feeding in the salamander Eurycea guttolineata.” Journal of Experimental Biology (2014) DOI: 10.1242/jeb.105437
- Reimche et al “The road not taken: Evolution of tetrodotoxin resistance in the Sierra garter snake (Thamnophis couchii) by a path less traveled” Molecular Ecology (2022) DOI: 10.1111/mec.16538
- Dyle, Michael C. et al. “Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy.” The Journal of Biological Chemistry (2014) DOI: 10.1074/jbc.M114.556241
- Verhaart et al. “Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy” Journal of Neuromuscular Disease (2021) DOI: 10.3233/JND-200524
- Jo-Avila, Miguel et al. “Relaxant effect of superimposed length oscillation on sensitized airway smooth muscle.” American Journal of Physiology: Lung Cellular and Molecular Physiology (2015) DOI: 10.1152/ajplung.00218.2014
- Klemm et al. “On a coupled electro-chemomechanical model of gastric smooth muscle contraction” Acta Biomaterialia (2020) DOI: 10.1016/j.actbio.2020.04.007
- Smith et al. “Novel γ-sarcoglycan interactors in murine muscle membranes” Skeletal Muscle (2022) DOI: 10.1186/s13395-021-00285-2
- Yang et al. “Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility” Science Signaling (2019) DOI: 10.1126/scisignal.aau1468
- Sreetama et al. “Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit” Molecular Therapy (2018) DOI: 10.1016/j.ymthe.2018.07.021
- Sreetama et al. “Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit” Molecular Therapy (2018) DOI: 10.1016/j.ymthe.2018.07.021
- Masschelein et al. “Exercise promotes satellite cell contribution to myofibers in a load-dependent manner” Skeletal Muscle (2020) DOI: 10.1186/s13395-020-00237-2
- Hakim, Chady H., Nalinda B. Wasala and Dongsheng Duan. “Evaluation of muscle function of the extensor digitorum longus muscle ex vivo and tibialis anterior muscle in situ in mice.” Journal of Visualized Experiments (2013) DOI: 10.3791/50183
- Olberding & Deban “Effects of temperature and force requirements on muscle work and power output” The Journal of Experimental Biology (2017) DOI: 10.1242/jeb.153114
- Vassilajos et al. “Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice” The FASEB Journal (2019) DOI: 10.1096/fj.201800459R
- Vassilajos et al. “Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice” The FASEB Journal (2019) DOI: 10.1096/fj.201800459R
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Specifications
| Apparatus | 800A | 805A |
|---|---|---|
| Type | Anodized Extruded Aluminum “T” Profile | |
| Tissue Clamp Movement [mm] | ±10 | |
| Travel per Knob Rotation [mm] | Course: 20 Fine: 2.6 |
|
| Bath Movement [mm] | Nominal: 70 Maximum: 200 |
Nominal: 100 Maximum: 200 |
| Bath | 800A | 805A |
|---|---|---|
| Type | Radnoti Tissue-Organ Bath with T.N.V Dispenser Tube | |
| Volume [ml] | 50 | 100 |
| Maximum Muscle Length [mm] | 45 | 55 |
| Dimensions [mm] | 51 OD x 34 ID x 75 D | 75 OD x 51 ID x 90 D |
| Temperature Control | Fully water-jacketed with quick disconnect fittings | |
| Stimulation Electrodes | 800A / 805A |
|---|---|
| Holder Material | Delrin |
| Type | Pure Platinum Bar |
| Dimensions [mm] | 2 W x 30AWG Thick x 50 L |
| General Specifications | 800A / 805A |
|---|---|
| Weight [kg] | 5.2 |
| Dimensions [cm] | 32W x 25D x 52H |