Moving Mountains: Recent Feats in Muscle Physiology

Cardiovascular, Muscle Physiology, Publication Review|

As we March towards the 2024 American Physiology Summit, this month’s publication review covers recent advancements in the realm of muscle physiology, including the development of an improved resistance training method, the long-term musculoskeletal consequences of chemotherapy, and the characterization of crossbridge kinetics in cardiac trabeculae. Taken together, these studies reveal a promising trend of breakthroughs in muscle physiology.

Tackling the Heart of the Issue: Advances in Cardiovascular Research

Cardiovascular, Muscle Physiology, Publication Review|

February notably marks “Heart Month”, aiming to highlight the importance of cardiovascular health and its critical implications on our overall wellbeing. Tackling the heart of the issue, several cardiovascular studies stand out as key players within the preclinical research landscape. The following publication review covers recent advancements in the field, including a promising therapeutic drug candidate for heart failure as well as novel insights into the cardiovascular biology of Marfan syndrome and muscle contraction regulation.

Molecular Deep Dives in Force Production

Muscle Physiology, Publication Review|

As we launch full force into 2024, studies exploring the molecular underpinnings of force production in mice have blazed the trail of functional muscular research. From calcium dynamics during muscle contraction, to muscle impairments in myotonic dystrophy, and the effects of running on muscle mass in a dystrophic mouse model, January's novel insights into muscle function and regulation have important implications on our understanding of muscle physiology and health.

Renewed Interests: Harnessing Engineered Constructs to Explore Novel Strategies in Regenerative Medicine

Cardiovascular, Materials Science, Muscle Physiology, Publication Review|

Tissue engineering is at the forefront of regenerative medicine, offering immense promise for restoring or enhancing the function of impaired tissues and organs. While tissue constructs remain costly in clinical settings, their use as a research tool holds vast potential for drug discovery, aiding and expediting the screening of drug candidates. In this publication review, we will discuss three recent publications leveraging specialized equipment from Aurora Scientific to advance the innovative field of engineered tissue constructs.

  • Integrating Patient Engagement and Trainee Development in Pre-Clinical Research

Integrating Patient Engagement and Trainee Development in Pre-Clinical Research

Events, Live Webinars, Muscle Physiology, On-Demand Webinars, Videos|

Christopher Perry, PhD discusses how his laboratory aims to discover mechanisms by which metabolic dysfunction causes muscle weakness and apply these findings to develop new therapies for muscle disorders. Homira Osman, PhD will provide a particular focus on leveraging scientific findings for practice and policy and linking trainees with patient communities.

  • Excellence, Innovation, and Collaboration

Excellence, Innovation, and Collaboration: Key Research at the MHRC

Cardiovascular, Interviews, Muscle Physiology, News, Videos|

This past April, we partnered with InsideScientific and the Muscle Health Research Centre (MHRC) at York University, a one-of-a-kind facility that fosters an interdisciplinary approach to the study of muscle physiology. We interviewed three keystone researchers who are shaping the future of skeletal muscle health: David Hood, PhD, Peter Backx, PhD, and Ali Abdul-Sater, PhD.

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