Explosive sensing with insect-based biorobots
Saha et al. utilize the biological olfactory system of locus insects to develop a bio-robotic chemical sensing system. Implantation of
Harnessing insect olfactory neural circuits for detecting and discriminating human cancers
Farnum et al. explore a novel approach to cancer detection by developing an insect olfactory neural circuit-based volatile organic compound
Odor-searching Robot with Insect-behavior-based Olfactory Sensor
The study focuses on the use of male silkmoths as biosensors for odour detection in mobile robots. Silkmoths exhibit high
Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress
Cancer-induced cachexia is a complex syndrome marked by skeletal muscle mass loss, impacting functional independence, quality of life, and cancer treatment outcomes. While muscle wasting has traditionally been attributed to circulating factors, recent research revealing mitochondrial dysfunction preceding the onset of muscle atrophy suggests it may play a role. Understanding the muscle-specific and time-dependent nature of mitochondrial responses to cancer may offer insights for targeted therapeutic interventions to mitigate muscle weakness and wasting in cachexia. This study examines the relationship between muscle dysfunction and mitochondrial bioenergetics in locomotor and respiratory muscles, revealing diverse responses that underscore the need for tailored approaches to treating muscle complications in cancer cachexia.
MYTHO is a novel regulator of skeletal muscle autophagy and integrity
The study identifies a novel FoxO-dependent gene called Mytho (Macroautophagy and YouTH Optimizer) as a regulator of autophagy and skeletal
Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth
Cancer-induced muscle wasting significantly impacts quality of life, hinders cancer treatments, and predicts early mortality. This study explores the role
Microdystrophin Gene Addition Significantly Improves Muscle Functionality and Diaphragm Muscle Histopathology in a Fibrotic Mouse Model of Duchenne Muscular Dystrophy
This study investigates the effectiveness of adeno-associated viral (AAV) vector-mediated microdystrophin gene addition therapy in a fibrotic mouse model of
Anti-RANKL Therapy Prevents Glucocorticoid-Induced Bone Loss and Promotes Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy
Bisphosphonates are recommended to prevent bone loss in glucocorticoid-treated boys with Duchenne muscular dystrophy (DMD). This study explores the potential
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) results from the absence of dystrophin, leading to membrane injury and a breakdown of muscle fibers.
Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues
This study utilizes human pluripotent stem cell (hPSC)-derived cardiomyocytes to explore ischemic heart failures. While previous studies demonstrate the potential
Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9
Thürkauf et al. establish an efficient CRISPR/Cas9 genome editing system for targeted, multiplexable gene knockouts in skeletal muscle fibers of
The cellular basis of mechanosensation in mammalian tongue
In this study, in-vivo calcium imaging of mouse trigeminal ganglion neurons is employed to identify functional groups of mechanosensory neurons
Combinatorial encoding of odors in the mosquito antennal lobe
This study focuses on how mosquitoes encode individual odourants from host smells in their brain. Using an in-vivo preparation for