Redox Regulation of Skeletal Muscle: A Journey from Liverpool to the International Space Station

Join Dr. Anne McArdle and Dr. Malcolm Jackson as they explore groundbreaking research from the Muscle Laboratories at the University of Liverpool. They'll examine how redox regulation influences the adaptive responses of skeletal muscle during physical activity and how these processes evolve with age.

This webinar covers the development of cutting-edge methodologies to study reactive oxygen species (ROS) in muscle cells and uncover their specific functions. They also discuss how age-related disruptions in redox balance can affect muscle responses, particularly in the production of heat shock proteins (HSPs). The webinar presents findings demonstrating that restoring HSP levels in older mice can enhance muscle mass and function. Additionally, they draw parallels between muscle responses in ageing and the rapid muscle loss observed during space flight. This is studied using 3D human muscle constructs on the International Space Station (ISS). Research indicates that microgravity impacts muscle contractions, and they show how HSP overexpression offers partial protection, mirroring the ageing process on Earth.

This session is ideal for anyone interested in the intersection of muscle biology, the ageing process, and space research.

Key Topics

• Innovative methodologies for studying reactive oxygen species (ROS) in muscle cells and their functions.
• Insights into how disrupted redox balance with age affects muscle response, especially the production of heat shock proteins (HSPs).
• Discoveries showing that restoring HSP levels in older mice improves muscle mass and function.
• Parallels between muscle response in ageing and rapid muscle loss during space flight, studied using 3D human muscle constructs on the International Space Station (ISS).
• Findings on how microgravity affects muscle contractions and how HSP overexpression provides partial protection, similar to the ageing process on Earth.