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300C-I: Dual-Mode Indenters

The 300C-I mechanical stimulator is an automated electronic von Frey device with the added capability to measure and control both force and length at a single application point. The 300C-I takes the variability and awkwardness out of applying force with a handheld von Frey filament or with other handheld mechanical stimulators. Our computer-controlled mechanical stimulator removes the unavoidable hand tremor associated with both von Frey filaments and other electronic von Frey systems. This removes the associated variation in force application.

Aurora Scientific’s mechanical stimulator increases throughput by eliminating the need for multiple tests to determine threshold. The force application and timing of the stimulus is consistent and precise, thereby removing the variability associated with handheld devices.

The mechanical stimulator is capable of applying constant force for pre-set periods of time with the added functionality of adjusting force at pre-determined rates. Stimulation can be applied in any combination of length or force and can follow an arbitrary force or distance application curve so force application is not limited to simple force ramps.

The delivery of constant and repeatable force ensures that consistency is maintained between experiments, subjects and studies, thus reducing avoidable error in your data and improving the quality of your findings.

2 Channel Mechanical Stimulator Variants:

300D-300I-300I: 2 Channel Mechanical Stimulator – both 300C-I
300D-300I-305I: 2 Channel Mechanical Stimulator – one 300C-I, one 305C-I
300D-305I-305I: 2 Channel Mechanical Stimulator – both 305C-I

  • quantify mechanosensitivity using computer-controlled stimuli
  • evaluate the suprathreshold mechanosensitivity
  • measure the mechanical threshold without performing multiple tests
  • force ranges: 0.5N – 10N
  • superior resolution (to 0.3mN)
  • operates in any orientation
  • minimizes off-axis forces
  • range of tips available (0.5, 0.8, 1, 1.5, 2, 3 mm diameter)
  • application area remains constant over full range of force

Customized 300C-I Facilitates Migraine Headache Research

CHALLENGE

In 2002 Dr. Dan Levy of Harvard University was studying the underlying mechanisms of migraine headaches and was looking for a method to reliably apply varying forces to sensory neurons innervating the dura mater of a rat.

300C-I – Mechanical Stimulation of Rat Skin

CHALLENGE

In 1998 Dr. Woodbury approached us with a need to perform mechanical stimulation of rat skin stretched in a recording chamber. He needed a computer controlled mechanical stimulator that could produce controlled five second square waves of varying forces through a cylindrical indenter tip.

Osteoarthritic Cartilage Loading with 2-Channel Mechanical Stimulator

CHALLENGE

Located in Department of Internal Medicine at Rush University, Dr. Rachel Miller studies the biomechanical pathways involved in Osteoarthritis pain. As a member of the Laboratory for Translational Research in Osteoarthritis, Dr. Miller is dedicated to elucidating these mechanisms that lead to debilitating pain in patients suffering from osteoarthritis, particularly in the knee joint. Dr. Miller approached Aurora Scientific as she was interested in a number of distinct applications centred on cartilage loading under an inverted microscope, from monolayer neuron cultures to intact animals.

Models In The Series

300C-I: Dual-Mode Indenter, 0.5N Force, 10mm Excursion

Seamless, flexible control of indentation force and length, with the unique ability to measure one or both in a single mechanical stimulator

300C-LR-I: Dual-Mode Indenter, 1N Force, 10mm Excursion

Seamless, flexible control of indentation force and length, with the unique ability to measure one or both in a single mechanical stimulator

305C-I: Dual-Mode Indenter, 5N Force, 20mm Excursion

Seamless, flexible control of indentation force and length, with the unique ability to measure one or both in a single mechanical stimulator

305C-LR-I: Dual-Mode Indenter, 10N Force, 20mm Excursion
Seamless, flexible control of indentation force and length, with the unique ability to measure one or both in a single mechanical stimulator