1301A

Isometric Whole Animal System for Mice

The Isometric Whole Animal System provides flexible and accurate measurement of rodent muscle properties in-vivo.

The 1301A is a high performing, precise test system, giving researchers a simple method to measure isometric mechanical properties of muscle. Utilizing our 490 series torque transducer, researchers have an excellent choice for basic isometric measurements such as twitch, tetanus, force-frequency and fatigue when throughput or lowering cost is a major consideration. Each torque transducer model is capable of measuring applied torque in both clockwise and anti-clockwise directions enabling measurements of antagonistic muscle groups across the joints of mice. The torque sensor heads are exceptionally durable, yet still offer the same low compliance and sensitivity as our motorized 300 series.

The system comes with a mouse apparatus, complete with temperature-controlled animal and limb plates designed to support and fix the animal and limb being tested. This system also includes our high-power, bi-phasic stimulator and all required electrodes for subcutaneous muscle and/or nerve stimulation.

Control and analysis software comes pre-loaded on a custom PC, making the process of experimental setup, data collection and data analysis consistent and reliable. With our control and analysis software (DMC/DMA), parameters such as resting force, stimulation and common mechanics experiments are set and ready to use.

mouse platform for in-vivo measurements

high experimental throughput
designed for basic isometric protocols
ideal for live animal protocols, enabling longitudinal analysis
bi-directional torque measurement

exceptionally durable, with low compliance and sensitivity
fast data acquisition and analysis software for Windows operating systems
dual purpose field/nerve stimulator
turn-key functionality

Survivable Measurements of Muscle Function

The isometric in-vivo system allows researchers to assess antagonistic muscle groups of the hindlimb and provide a convenient platform for longitudinal analysis, compound screening, phenotype evaluation, and comparison of murine models.

High Throughput Software Capability

Experience high-throughput data analysis, including batch processing and multi-parameter calculations for hundreds of muscle samples within minutes. Downstream analysis can be completed within Aurora Scientific DMC/DMA software or exported to your analysis program of choice.

Standard Protocol Library

The protocol library includes a variety of muscle experiments for mouse in-vivo studies. Protocols include system operation and data acquisition settings optimized for measurement needs. Custom protocols can be added to streamline system operation with multiple lab members.

Select References

Segales et al. “Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals” Nature communications (2020) DOI: 10.1038/s41467-019-13832-9
Gorini et al. “Reversible temporally-specific inhibition of muscle using a light-activated chloride channel” bioRxiv (2018) DOI: 10.1101/398156
Cosentino et al. “Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia” Scientific Reports (2023) DOI: 10.1038/s41598-023-37553-8
Llewellyn, Michael E. et al. “Orderly recruitment of motor units under optical control in vivo.” Nature Medicine (2010) DOI: 10.1038/nm.2228
Ma et al. “Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle” Internation Journal of Molecular Sciences (2018) DOI: 10.3390/ijms19092643
Hamoudi et al. “Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice” Human Molecular Genetics (2020) DOI: 10.1093/hmg/ddz312
Zhao et al. “Meningeal P2X7 Signaling Mediates Migraine-Related Intracranial Mechanical Hypersensitivity” The Journal of Neuroscience (2023) DOI: 10.1523/JNEUROSCI.0368-23.2023
Ottenheijm, Coen A.C. et al. “ltered contractility of skeletal muscle in mice deficient in titin’s M-band region.” Journal of Molecular Biology (2009) DOI: 10.1016/j.jmb.2009.08.009
Jackson, Janna R., Michael J. Ryan, and Stephen E. Alway. “Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences (2011) DOI: 10.1093/gerona/glr047
Gruebele et al. “Long-Stroke Rolling Diaphragm Actuators For Haptic Display of Forces in Teleoperation” IEEE Robotics and Automation Letters (2019) DOI: 10.1109/LRA.2019.2894867

System Components

608C: LCD Monitor

A 22” widescreen LCD monitor providing high quality visualization of data collection

Interested in the 1301A: Isometric Whole Animal System for Mice?

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Resources

Parts & Accessories

Model #	1301A
300-FP	Footplate for mouse in-vivo measurements that clamps to a 490 series torque transducer
808-6	Upright knee clamp designed for mouse that uses a horizontal dowel pin with pad for non-invasive knee restraint during in-vivo or in-situ experiments. It mounts on our family of 3-in-1 apparatus.
830A	Half-rack adapter that allows half-rack instruments to be mounted in standard 19” racking. Works with models: 315D/322D, 400C series, 490A series, 701C and 825A.
831A	Heavy gauge, steel desktop or shelf-top rack, with standard 19” width for any Aurora Scientific instruments. Available in various heights. (6U high for 1200C and 1300A, 5U high for 1400A, 1500A and 1600A systems).