1301A
Isometric Whole Animal System for Mice
The Isometric Whole Animal System provides flexible and accurate measurement of rodent muscle properties in-vivo.
The 1301A is a high performing, precise test system, giving researchers a simple method to measure isometric mechanical properties of muscle. Utilizing our 490 series torque transducer, researchers have an excellent choice for basic isometric measurements such as twitch, tetanus, force-frequency and fatigue when throughput or lowering cost is a major consideration. Each torque transducer model is capable of measuring applied torque in both clockwise and anti-clockwise directions enabling measurements of antagonistic muscle groups across the joints of mice. The torque sensor heads are exceptionally durable, yet still offer the same low compliance and sensitivity as our motorized 300 series.
The system comes with a mouse apparatus, complete with temperature-controlled animal and limb plates designed to support and fix the animal and limb being tested. This system also includes our high-power, bi-phasic stimulator and all required electrodes for subcutaneous muscle and/or nerve stimulation.
Control and analysis software comes pre-loaded on a custom PC, making the process of experimental setup, data collection and data analysis consistent and reliable. With our control and analysis software (DMC/DMA), parameters such as resting force, stimulation and common mechanics experiments are set and ready to use.
![809C with 490A in-vivo wide 809C with 490A in-vivo](https://aurorascientific.com/wp-content/uploads/2024/06/ASI_809C_490A_WIDE_02-FS-scaled.jpg)
mouse platform for in-vivo measurements
Survivable Measurements of Muscle Function
The isometric in-vivo system allows researchers to assess antagonistic muscle groups of the hindlimb and provide a convenient platform for longitudinal analysis, compound screening, phenotype evaluation, and comparison of murine models.
High Throughput Software Capability
Experience high-throughput data analysis, including batch processing and multi-parameter calculations for hundreds of muscle samples within minutes. Downstream analysis can be completed within Aurora Scientific DMC/DMA software or exported to your analysis program of choice.
Standard Protocol Library
The protocol library includes a variety of muscle experiments for mouse in-vivo studies. Protocols include system operation and data acquisition settings optimized for measurement needs. Custom protocols can be added to streamline system operation with multiple lab members.
Select References
- Segales et al. “Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals” Nature communications (2020) DOI: 10.1038/s41467-019-13832-9
- Gorini et al. “Reversible temporally-specific inhibition of muscle using a light-activated chloride channel” bioRxiv (2018) DOI: 10.1101/398156
- Cosentino et al. “Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia” Scientific Reports (2023) DOI: 10.1038/s41598-023-37553-8
- Llewellyn, Michael E. et al. “Orderly recruitment of motor units under optical control in vivo.” Nature Medicine (2010) DOI: 10.1038/nm.2228
- Ma et al. “Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle” Internation Journal of Molecular Sciences (2018) DOI: 10.3390/ijms19092643
- Hamoudi et al. “Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice” Human Molecular Genetics (2020) DOI: 10.1093/hmg/ddz312
- Zhao et al. “Meningeal P2X7 Signaling Mediates Migraine-Related Intracranial Mechanical Hypersensitivity” The Journal of Neuroscience (2023) DOI: 10.1523/JNEUROSCI.0368-23.2023
- Ottenheijm, Coen A.C. et al. “ltered contractility of skeletal muscle in mice deficient in titin’s M-band region.” Journal of Molecular Biology (2009) DOI: 10.1016/j.jmb.2009.08.009
- Jackson, Janna R., Michael J. Ryan, and Stephen E. Alway. “Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences (2011) DOI: 10.1093/gerona/glr047
- Gruebele et al. “Long-Stroke Rolling Diaphragm Actuators For Haptic Display of Forces in Teleoperation” IEEE Robotics and Automation Letters (2019) DOI: 10.1109/LRA.2019.2894867
System Components
490A: Torque Transducer
The 400C series of force transducers is the next generation of our widely used 400A and 400B series. The 400C series enables contractile measurements from a variety of muscle types and sizes and are designed to meet the needs of muscle researchers.
Learn More605A: Dynamic Muscle Data Acquisition and Analysis System
Precise, custom software designed for real-time data acquisition, instrument control and data analysis with unique, integrative features. Includes force and SL control capability
Learn More701C: Electrical Stimulator
Our high-powered, bi-phase stimulator designed for muscle researchers conducting the most demanding field stimulation protocols.
Learn More809C: in-situ Mouse Apparatus
A beautifully designed, flexible apparatus for easily measuring in vitro, in situ and in vivo muscle properties in mice
Learn More![608C-LCD Monitor 608C-LCD Monitor](https://aurorascientific.com/wp-content/uploads/2021/07/608C-LCD-Monitor.jpg)
608C: LCD Monitor
A 22” widescreen LCD monitor providing high quality visualization of data collection
Resources
Parts & Accessories
Model # | 1301A |
---|---|
300-FP | Footplate for mouse in-vivo measurements that clamps to a 490 series torque transducer |
808-6 | Upright knee clamp designed for mouse that uses a horizontal dowel pin with pad for non-invasive knee restraint during in-vivo or in-situ experiments. It mounts on our family of 3-in-1 apparatus. |
830A | Half-rack adapter that allows half-rack instruments to be mounted in standard 19” racking. Works with models: 315D/322D, 400C series, 490A series, 701C and 825A. |
831A | Heavy gauge, steel desktop or shelf-top rack, with standard 19” width for any Aurora Scientific instruments. Available in various heights. (6U high for 1200C and 1300A, 5U high for 1400A, 1500A and 1600A systems). |