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1300A: 3-in-1 Whole Animal System – Mouse

The 3-in-1 Whole Animal System provides flexible and accurate measurement of rodent muscle properties in-situ, in-vivo and in-vitro.

The 1300A and 1305A are high performing, precise test systems, giving researchers a simple method to test tensile and other mechanical properties of muscle. By combining in-situ, in-vivo and in-vitro muscle tests using one simple platform, researchers can capture a complete picture of muscle physiology in rodent subjects. The test systems come with either a mouse or rat apparatus, complete with temperature-controlled animal and limb plates designed to support and fix the animal and limb being tested. The system can be converted to an isolated (in-vitro) muscle test system with the attachment of an optional 25mL bath. Aurora Scientific’s flagship Dual-Mode lever system is also included, permitting measurement and control of both force and length.

Conveniently, muscle samples are attached at only one point to measure force and length, saving time and increasing productivity. This system also includes our high-power, bi-phasic stimulator and all required electrodes.

Control and analysis software comes pre-loaded on a custom PC, making the process of experimental setup, data collection and data analysis consistent and reliable.

With our control and analysis software (DMC/DMA), parameters such as resting length, resting force, stimulation and the actual test protocol are set and ready to use. An extensive library of standard experimental protocols such as twitch, tetanus, fatigue, force-frequency, force-velocity, stiffness and work loops are provided with the system.

Tell the Whole Story – Live Animal & Isolated Tissue in One

The three system configurations allows the researcher to work with a broad range of muscle types, providing a convenient platform for compound screening, phenotype evaluation and comparison of murine models; all within one system.

High Throughput Software Capability

Experience high-throughput data analysis, including batch processing and multi-parameter calculations for hundreds of muscle samples within minutes. Downstream analysis can be completed within Aurora Scientific DMC/DMA software or exported to your analysis program of choice.

Standard Protocol Library

The protocol library includes a variety of muscle experiments for rat in vitro studies. Protocols include system operation and data acquisition settings optimized for sample type and measurement needs. Add your own custom protocols as well to streamline system operation with multiple lab members.

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  • powerful 3-in-1 design: save time and space while increasing productivity
  • high experimental throughput
  • fast data acquisition and analysis software for Windows or Linux operating systems
  • dual purpose field/nerve stimulator
  • ideal for live animal protocols: precision platform with temperature control
  • convenience of one test system capable of studying both mice and rats
  • range of peak forces from 0.5N to 10N

1300A – 3-in-1 Test System Helps Major Pharmaceutical Companies Dramatically Improve Throughput

CHALLENGE

Several large, Fortune 500 pharmaceutical companies sought a way to quickly screen large groups of mice that had been treated with new experimental compounds/therapies.  Existing equipment in house was either unavailable or difficult to use and lacked the capabilities needed to meet throughput demands.  The precision of any in house equipment was also questionable.

3-in-1 in-situ System Enables Biologist to Test Physiology of Muscle Regeneration

CHALLENGE

As a molecular and developmental biologist, Dr. Chen-Ming Fan of the Carnegie Institution for Science studies the molecular mechanisms involved in mammalian development, most notably in the musculoskeletal system. Over the years Dr. Fan has uncovered developmental mechanisms that are involved in muscle regeneration through the skeletal muscle stem cell niche, as regeneration is thought to be a recapitulation of development processes.

Models Included With This System

300C-FP: Dual-Mode Footplate

Seamless, flexible control and measure of force and length, designed for in vivo mechanics of mouse plantar and dorsi flexors.

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605A: Dynamic Muscle Data Acquisition And Analysis System

Integrated, Windows based, powerful and complete data acquisition and analysis system handling the entire data collection, control and analysis of muscle contractile experiments.

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608C: LCD Monitor

A 22” widescreen LCD monitor providing high quality visualization of data collection

701C: Electrical Stimulator

The ideal solution for field stimulation with the flexibility and control required for use as a nerve and in situ muscle stimulator.

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809C: in-situ Mouse Apparatus

A beautifully designed, flexible apparatus for easily measuring in vitro, in situ and in vivo muscle properties in mice.

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