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1305A: 3-in-1 Whole Animal System – Rat

The 3-in-1 Whole Animal System delivers accurate and flexible measurement of rodent muscle properties in-situ, in-vivo and in-vitro. Ideal for live animal protocols, including injury and longitudinal studies, it evaluates the mechanical characteristics of intact muscle of rats, either isolated in-situ, with a footplate (ex-vivo) or isolated in-vitro. Experimental setup, data collection and data analysis can all be done in a matter of minutes.

By combining in-situ, in-vivo and in-vitro muscle tests, researchers are able to capture a complete picture of muscle physiology in rats. The test system comes with the rat apparatus, complete with temperature controlled animal and limb plates designed to support and fix the animal and limb being testing. It can be converted to an isolated (in-vitro) muscle test system with the attachment of an optional 25 mL bath. Aurora Scientific’s flagship Dual-Mode lever system is also included, permitting measurement and control of both force and length.

Muscle samples are attached at only one point to measure force and length saving time and increasing productivity. The system includes our high-power, field stimulator and all required electrodes.

Control and analysis software comes pre-loaded on a custom PC. Experimental setup, data collection and data analysis can all be done in a matter of minutes with our control and analysis software (DMC/DMA). Parameters such as resting length, resting force, stimulation and the actual test protocol are all set using the control software. An extensive library of standard experimental protocols such as twitch, tetanus, fatigue, force-frequency, force-velocity, stiffness and work loops are also provided with the system.

Tell the Whole Story – Live Animal & Isolated Tissue in One

The three system configurations allows the researcher to work with a broad range of muscle types, providing a convenient platform for compound screening, phenotype evaluation and comparison of murine models; all within one system.

High Throughput Software Capability

Experience high-throughput data analysis, including batch processing and multi-parameter calculations for hundreds of muscle samples within minutes. Downstream analysis can be completed within Aurora Scientific DMC/DMA software or exported to your analysis program of choice.

Standard Protocol Library

The protocol library includes a variety of muscle experiments for rat in vitro studies. Protocols include system operation and data acquisition settings optimized for sample type and measurement needs. Add your own custom protocols as well to streamline system operation with multiple lab members.

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1500A: Isolated Muscle System - Microscope Mountable

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Measure complete mechanical properties of small samples with a turnkey system for intact muscle and physiological tissues.

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  • powerful 3-in-1 design: save time and space while increasing productivity
  • turn-key functionality
  • high experiment throughput
  • fast data acquisition and analysis software for Windows
  • dual purpose field/nerve stimulator
  • ideal for live animal protocols: precision platform with temperature control
  • simple to assemble, operate, and expand as your measurement needs change
  • capable of more complex multi-measurement protocols

1305A – Footplate Configuration for Rats Invaluable to the Study of Muscle Damage

CHALLENGE

In 2012, Marius Locke at the University of Toronto had been studying skeletal muscle damage and the role that heat shock proteins (HSPs) play in protecting the muscle from stress induced damage, such as exercise.  Dr. Locke was looking for equipment that could reliably and repeatedly induce muscle damage in his rats while accurately quantifying force production and recovery.

SOLUTION

Our 1305A system was suggested for the job as it had the ability to perform the kinds of repeated contractions that Dr. Locke was looking to accomplish. It was first implemented piecemeal to integrate with some existing equipment in the laboratory, but because of its ease of use, the remaining Aurora Scientific pieces were added for a complete system.  Aurora Scientific technical support helped craft the best protocols for Dr. Locke’s experiments and soon thereafter the first cohort of rats was tested.

RESULTS

The system has helped Dr. Locke and his graduate students publish valuable findings about the protective role of HSPs in damaged muscle. In addition, Dr. Locke established an important rat model of standard human exercise protocols to gain valuable, physiologically relevant data which may one day be applicable to athletes and people alike.

Models Included With This System

305C-FP: Dual-Mode Footplate

Seamless, flexible control and measure of force and length, designed for in-vivo mechanics of rat plantar and dorsi flexors.

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605A: Dynamic Muscle Data Acquisition And Analysis System

Integrated, Windows based, powerful and complete data acquisition and analysis system handling the entire data collection, control and analysis of muscle contractile experiments.

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608C: LCD Monitor

A 22” widescreen LCD monitor providing high quality visualization of data collection.

701C: Electrical Stimulator

The ideal solution for field stimulation with the flexibility and control required for use as a nerve and in-situ muscle stimulator.

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806D: in-situ Rat Apparatus

A beautifully designed, innovative apparatus for measuring in-vitro, in-situ and in-vivo muscle properties in rats.

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