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1700A: Myofibril System – Microscope Mountable

The 1700A Myofibril System is the first commercially available myofibril system specifically designed to measure the nano Newton forces arising from activation of single myofibrils.  This is a complete test system, including all hardware required to characterize myofibril contraction. The 1700A includes: 470A Myofibril Atomic Force Microscopy (AFM) Transducer, 340A Piezo Length Controller, temperature controlled bath, 470A-XYZ motorized translation stages, 820A Dual XYZ Motion Controller for computer control of both AFM cantilever and glass needle positioning, solution valve controller, solution switching motor driver and our real-time Linux 600A Data Acquisition System.

The 470 Myofibril AFM Transducer utilizes atomic force microscopy and the optical beam deflection method to measure the nano Newton forces that arise from single myofibril activation. The myofibril is held between an AFM cantilever, which acts as a highly-sensitive force transducer, and a glass needle, connected to the 340A Piezo Length Controller. Controlling length and measuring force allows the 1700A Myofibril System to provide complete mechanical characterization of the myofibril.  Depending on the cantilever used, the full-scale force is 1-10µN with an astounding resolution of 1nN.

The 1700A contains a temperature regulated tissue bath as well as controls for a buffer exchange system, crucial components for quick activation of any myofibril. The apparatus can easily be mounted on an inverted microscope, providing easy and clear access to both the bath and myofibril.

Customizable protocols for mechanical characterization of myofibrils can be performed using our 600A Data Acquisition System and when combined with our optional 900B/901C VSL sarcomere length measurement software, the researcher can control and measure length, force, and sarcomere length.

The 1700A Myofibril System was invented by Dilson Rassier and Aleksander Labuda, McGill University, Montreal, Canada where it was nicknamed “The Penguin”. The 1700A System is Patent Pending (US Patent Application No.: 13/097,197). Aurora Scientific is the exclusive, worldwide, licensee of the 1700A “Penguin” system.

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  • complete test system for permeabilized myofibrils
  • temperature regulated tissue bath
  • simple mounting on an inverted microscope
  • computer controlled, motorized XYZ micro-positioning stages
  • includes buffer valve and of a solution switcher contols
  • control and measure force, length, and sarcomere spacing
  • measure force-pCa, kTr, stiffness, length-tension and force-velocity relationships
  • seamlessly interfaces with Aurora Scientific 900B High-Speed Video Sarcomere Length system (HVSL)

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Models Included With This System

340A: Piezo Length Controller

Exceptionally fast length control with sub-micron resolution for small fibers, cells and myofibrils

470A: Myofibril AFM Transducer

Atomic Force Measurement transducer specifically designed to measure the nano newton forces arising from activation of single myofibrils

470A-XYZ: Dual Motorized XYZ Stages

Dual 3-axis motorized stages with sub-micron resolution for positioning of AFM sensor and 340A Piezo Length Controller

600A: Real-Time Muscle Data Acquisition and Analysis System

A precision, real-time controller and data acquisition system for Aurora Scientific apparatus and measurement devices

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608C: LCD Monitor

A 22” widescreen LCD monitor providing high quality visualization of data collection

820A: Dual XYZ Motion Controller

A precision, computerized controller for 470A-XYZ stages with sub-micron accuracy

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