1205A
Isolated Muscle Test System for Rats
The 1205A isolated muscle test system is the leading solution for quantifying mechanical properties of isolated muscle. This system is ideal for a number of limb muscles, including the TA, EDL, Soleus, Gastroc, diaphragm strips and smaller muscle samples.
Included is an apparatus designed for rat muscle, complete with a water-jacketed bath and oxygenating bubbler. There is also our flagship Dual-Mode muscle lever system, a high-power field stimulator, data acquisition hardware and control and analysis software. Experimental setup, data collection and data analysis can all be done in a matter of minutes.
Parameters such as resting length, resting force, stimulation and the actual test protocol are all set using the control software. An extensive library of standard experimental protocols such as twitch, tetanus, fatigue, force-frequency, force-velocity, stiffness and work loops are provided with the system.
The experimental apparatus is adjustable, allowing the researcher to lower and raise the bath to attach and manipulate the muscle. Force and length are measured at only one attachment point, minimizing setup time and boosting productivity.
NEW! Order this system with the 150A Integrated Muscle Test Controller. The 150A is a single unit that combines a lever system, stimulator and USB DAQ card into a single controller. This results in a smaller footprint system with minimal cabling that is portable and can be controlled with laptop! When requesting information or pricing, please reference Model 1205B – Integrated in-vitro Muscle Test System.
Go Beyond Isometric Measurements
Complete characterization of muscle function is achieved using our 300C series Dual-Mode muscle levers; a force transducer and fast length motor in one. Isotonic, eccentric and force-velocity protocols are easily accomplished and supplement basic isometric twitch and tetanus measurements.
Lightning Fast Data Analysis
Experience high-throughput data analysis, including batch processing and multi-parameter calculations for hundreds of muscle samples within minutes. Downstream analysis can be completed within Aurora Scientific DMC/DMA software or exported to your analysis program of choice.
Precise and Robust Components
Aurora Scientific has a long history of supplying some of the most accurate transducers and muscle physiology components for life science research. Our legacy systems date back more than 30 years with many still in use today..
Standard Protocol Library
The protocol library includes a variety of muscle experiments for rat in-vitro studies. Protocols include system operation and data acquisition settings optimized for sample type and measurement needs. Add your own custom protocols as well to streamline system operation with multiple lab members.
Select References
- Anderson, Brian C. et al. “Sustained release of bone morphogenetic protein-4 in adult rabbit extraocular muscle results in decreased force and muscle size: potential for strabismus treatment.” Investigative Ophthalmology & Visual Science (2011) DOI: 10.1167/iovs.10-6878
- Karisnan, Kanakeswary et al. “Interleukin-1 Receptor Antagonist Protects against Lipopolysaccharide Induced Diaphragm Weakness in Preterm Lambs.” PLoS One (2015) DOI: 10.1371/journal.pone.0124390
- Zhang, Chi and Yingxin Gao “Effects of aging on the lateral transmission of force in rat skeletal muscle.” Journal of Biomechanics (2014) DOI: 10.1016/j.jbiomech.2014.01.026
- Song, Yong et al. “Effect of maternal steroid on developing diaphragm integrity.” PLoS One (2014) DOI: 10.1371/journal.pone.0093224
- Lavin, T. et al. “Developmental changes in diaphragm muscle function in the preterm and postnatal lamb.” Pediatric Pulmonology (2013) DOI: 10.1002/ppul.22762
- Segales et al. “Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals” Nature communications (2020) DOI: 10.1038/s41467-019-13832-9
- Gorini et al. “Reversible temporally-specific inhibition of muscle using a light-activated chloride channel” bioRxiv (2018) DOI: 10.1101/398156
- Cosentino et al. “Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia” Scientific Reports (2023) DOI: 10.1038/s41598-023-37553-8
- Llewellyn, Michael E. et al. “Orderly recruitment of motor units under optical control in vivo.” Nature Medicine (2010) DOI: 10.1038/nm.2228
- Ma et al. “Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle” Internation Journal of Molecular Sciences (2018) DOI: 10.3390/ijms19092643
System Components
300E: Dual-Mode Muscle Levers
Seamless, flexible control of force and length, with the unique ability to measure one or both in a single and convenient lever system.
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400C: Force Transducers
The 400C series of force transducers is the next generation of our widely used 400A and 400B series. The 400C series enables contractile measurements from a variety of muscle types and sizes and are designed to meet the needs of muscle researchers.
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605A: Dynamic Muscle Data Acquisition and Analysis System
Precise, custom software designed for real-time data acquisition, instrument control and data analysis with unique, integrative features. Includes force and SL control capability
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701C: Electrical Stimulator
Our high-powered, bi-phase stimulator designed for muscle researchers conducting the most demanding field stimulation protocols.
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800C: in-vitro Muscle Apparatus
Flexible design makes these systems the ideal choice for measuring muscle properties of intact muscle tissue in mice and rats
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608C: LCD Monitor
A 22” widescreen LCD monitor providing high quality visualization of data collection
Resources
Parts & Accessories
| Model # | 1205A |
|---|---|
| 800-EA | Replacement electrode assembly |
| 805-LTC | Lower tissue clamp assembly for 805A rat in-vitro apparatus – includes: electrode clamp, lower tissue clamp, lower tissue plate, support tube and support tube clamp |
| 800-FT | Adaptor mount for 400A series force transducers – converts 800A/805A to strictly isometric |
| 800-TB-100 | 100mL Radnoti tissue bath which mounts to 805A rat in-vitro apparatus |
| 800-OXY | Oxygenating tube for Radnoti tissue bath |
| 800-TC-18 | Teflon thermocouple probe for measuring bath temperature |
| 300-3B | 3 cm long replacement lever arm, attaches to 300C or older 300B series motors for in-vitro and in-situ measurement |
| 300-4B | 4 cm long replacement lever arm, attaches to 305C or older 305B series motors for in-vitro and in-situ measurement |
| 300-CLA | Custom length replacement lever arm, attaches to 300C/305C or older 300B/305B series motors for in-vitro and in-situ measurement |
| 300-CBL-3 | 3m replacement motor cable (Other lengths available on request) |
| 300-CBL-FR | 0.4m long cable to reverse force direction of 300C/305C motor |
| 6350 | Replacement motor for 300C dual-mode lever system (Lever arm sold separately) |
| 6650-LR | Replacement motor for 305C dual-mode lever system (Lever arm sold separately) |
| 606A | 150cm long BNC to BNC cable |
| 603D | 16-bit NI X Series USB A/D with interface |
| 603E | 16-bit NI X Series PCI express A/D card |
| 606A | 150cm long BNC to BNC cable |
| 607B | 50 Ohm BNC Tee adapter allowing connection of two BNC cables to one BNC port |
| 615B | 2nd Copy of DMC and DMA suite software |
| 615C | DMC and DMA suite software upgrade |
| 608C | 22” LCD monitor |
| 827A | Heated Water Circulator for maintaining temperature of bath solution (North America power ONLY) |
| 830A | Half-rack adapter that allows half-rack instruments to be mounted in standard 19” racking (works with models: 400A series and 701C) |
| 831A | Heavy gauge, steel desktop or shelf-top rack, with standard 19” width for any Aurora Scientific Instruments (6U high for 1200A) |