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809C: in-situ Mouse Apparatus

The 809C mouse apparatus performs three different tests for measuring muscle properties using a single, easy-to-use platform. In two of these configurations, the apparatus is mounted with an animal and limb plate for measuring contractions in-situ (using a lever arm) or muscle dynamics in-vivo (using a footplate). The third configuration involves the addition of a 25mL horizontal in-vitro bath, enabling contractile measurements in isolated, intact muscle using a lever arm.

The animal platform is temperature-controlled and adjustable to ensure clear access to the animal while positioning the limb. A variety of limb clamps for specific applications and research subjects are also available, creating greater ease of use during examination.

The 809C is compatible with our 300C series of muscle levers . All models are mounted on slides to position the lever easily with respect to the limb. Motor mounts also provide a fine translation stage to properly set resting tension of the muscle.

in-vitro Bath Variant:

809C-IV: in-vitro Mouse Apparatus
Perform in-vitro experiments on intact mouse muscle in the 25 mL horizontal bath

  • in-vitro, in-situ and in-vivo muscle experimentation in one platform
  • designed specifically for mouse applications
  • simple to switch between configurations
  • flexible limb clamping
  • adjustable animal platform with option for temperature control using a circulating bath
  • dual coarse/fine translation stage
  • T-slot design for flexibility and expansion
  • corrosion resistant materials

809C – in-vitro Configuration Sheds Light on the Relationship Between Muscle and Nerve

CHALLENGE

In 2010, Dr. Katherine Wilkinson, then a postdoc at Emory University, approached us about equipment for testing EDL muscle from mice. Specifically, Dr. Wilkinson was interested in sensory neurons innervating the skeletal muscle and how these neurons fire in response to various mechanical, chemical and other stimuli from the muscle.

809C Helps Neuroscientist Assess Muscle Function in Model of Peripheral Nerve Injury.

CHALLENGE

Dr. Young-Jin Son at Shriners Hospitals Pediatric Research Center studies peripheral nerve regeneration and the role Schwann cells play in maintaining and aiding regeneration of synaptic connections. Dr. Son was looking for a way to test functional recovery in mice with peripheral nerve injury in addition to measuring number of motor units and neuromuscular junction (NMJ) properties.

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