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400A: Force Transducers

The 400A series of high-level output force transducers enables measurement of a wide range of muscle types and sizes and are designed to meet the needs of muscle researchers. Each model has bi-directional force measurement capabilities. These transducers are more rugged and have less compliance than semi-conductor strain gauges. Physiologists now have a reliable and accurate way to quickly measure the contractile properties of all muscle types and connective tissue.

The 400A series of force transducers consists of seven unique models with a resolution to 10nN (1 microgram). With a frequency response up to 4kHz, researchers can measure force from individual cells, single fibers and whole muscle covering a force range from 0.5mN to 1000mN.

Researchers can now confidently measure force with extremely low compliance, eliminating any motion in the sample. The design provides excellent thermal stability and minimal sensitivity to vibration and interference. It provides reliability and ease of use without troublesome compensation techniques.

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403A-CF: Force Transducer With Carbon Fiber Attachment
Complete, ready-to-use force transducers designed for fast response, high resolution and low compliance measurement of force – 2mN full range

  • measure force production of skeletal, smooth and cardiac muscle as well as connective tissue
  • maximum forces from 0.5mN – 1000mN
  • bi-directional force capability
  • fast response, up to 4kHz
  • high resolution (10nN for 406A)
  • incredibly low compliance (5µm at full load – all models)
  • excellent thermal stability
  • rejection of ambient vibrations or interference
  • rugged and repairable
  • ready-to-use, complete with sensor head and electronics
  • digital output display
  • easy-to-use

400A – Studying cancer cachexia in mouse models

CHALLENGE

In 2011 Dr. Theresa Guise and her colleague Dr. Andrew Marks approached Aurora Scientific seeking help in functionally characterizing muscle from their mouse tumor model. They were looking to assess the progression of muscle loss and weakness in these mice and investigate potential therapies.

Because the pathology in these mice was incredibly aggressive, many animals would need to be tested in a short period of time. This would necessitate the use of multiple rigs and a robust transducer that allowed for high throughput. Because Dr. Guise was only looking to perform basic isometric strength and fatigue measures, a dual-mode lever system would have been prohibitively expensive for its capabilities.

SOLUTION

Enter the Aurora Scientific 407A. As the transducer in the 400A series with the greatest force measurement capacity, it was suitable for making isometric force measurements in whole skeletal muscle from mouse. The unit is the most robust out of the whole 400A series, lessening the risk of accidental damage. The 407A was effectively paired with a modified 800A in-vitro muscle apparatus, as well as our 701C electrical stimulator and 615A DMC/DMA software.

RESULTS

The 407A transducer helped the labs of Dr. Guise and Dr. Marks to test many mouse models of cancer cachexia and performed so well that several more units were required in both labs to keep up with demand. Using the Aurora Scientific 407A, these researchers were ultimately able to determine the mechanisms and pathways that cause muscle weakness associated with various cancers. These results and many others were recently published in Nature Medicine.

Models In The Series

400A - 50mN

Complete, ready-to-use force transducers designed for fast response, high resolution and low compliance measurement of mechanical properties – 50mN

402A - 500mN

Complete, ready-to-use force transducers designed for fast response, high resolution and low compliance measurement of mechanical properties – 500mN

403A - 5mN

Complete, ready-to-use force transducers designed for fast response, high resolution and low compliance measurement of mechanical properties – 5mN

404A - 100mN

Complete, ready-to-use force transducers designed for fast response, high resolution and low compliance measurement of mechanical properties – 100mN

405A - 10mN

Complete, ready-to-use force transducers designed for fast response, high resolution and low compliance measurement of mechanical properties – 10mN

406A - 0.5mN

Complete, ready-to-use force transducers designed for fast response, high resolution and low compliance measurement of mechanical properties – 0.5mN

407A - 1000mN

Complete, ready-to-use force transducers designed for fast response, high resolution and low compliance measurement of mechanical properties – 1000mN