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Muscle Pathology & Wasting

As the largest generation in history enters their senior years, research into muscle pathologies has come into greater focus. These can include rare conditions like muscular dystrophy or more commonly, muscle atrophy due to cancer or disuse after injury. To develop drugs and therapies that combat this broad group of myopathies, functional measurements of muscle are often required in animal models. Aurora Scientific has worked with researchers in this community to provide tools that allow the study of muscles like the diaphragm as well as non-invasive assays to perform longitudinal tests on an individual animal as a disease or therapy progresses. We are proud of our long history working with the leading researchers and academics in this field and proud of the role our muscle pathology research instruments have played.

Muscle Atrophy Through Disease, Disuse or Chronic Injury

Duchenne muscular dystrophy (DMD), cachexia & sarcopenia, gerontology & aging, muscle atrophy, Spinal Muscular Atrophy (SMA), myotonia, glycogen storage disease type II (Pompe Disease), myotubular myopathy

1500A: Isolated Muscle System - Microscope Mountable

1500A: Isolated Muscle System - Microscope Mountable

Measure complete mechanical properties of small samples with a turnkey system for intact muscle and physiological tissues.
1200A: Isolated Muscle System - Mouse

1200A: Isolated Muscle System - Mouse

The industry leading, easy-to-use test system for measuring the mechanical properties of isolated muscle, bundles and strips.
1300A: 3-in-1 Whole Animal System - Mouse

1300A: 3-in-1 Whole Animal System - Mouse

A flexible test system that delivers accurate measurement of rodent muscle properties in-situ, in-vivo and in-vitro.

Dr. Leo Ferreira – University of Florida

The equipment and customer support I have received from Aurora Scientific is amazing. Their engineers and software developers have spent countless hours tailoring protocols, software, and apparatuses to meet my needs. Their support and assistance have strengthened my research tremendously. I consider my relationship with Aurora Scientific to be a true partnership.

Dr. Coen Ottenheijm – Vrie Universitet

Several Aurora Scientific systems are in use in my lab. Their equipment has allowed us to generate precise, publishable data for many years. Their local support team has a good relationship with my lab workers, allowing us to resolve issues quickly and with a minimum of disruption. I consider them to be a valued collaborator in our work.

1200A – Easy To Use System Is an Invaluable Tool for Lab

CHALLENGE

In 2013 Aurora Scientific was approached by Dr. Espen Spangenburg at the University of Maryland about our 1200A test system for working with isolated EDL and soleus muscle taken from mice.

1300A – 3-in-1 Test System Helps Major Pharmaceutical Companies Dramatically Improve Throughput

CHALLENGE

Several large Fortune 500 pharmaceutical companies sought a way to quickly screen large groups of mice that had been treated with new experimental compounds/therapies.

1305A – Footplate Configuration for Rats Invaluable to the Study of Muscle Damage

CHALLENGE

In 2012, Marius Locke at the University of Toronto had been studying skeletal muscle damage and the role that heat shock proteins (HSPs) play in protecting the muscle from stress-induced damage, such as exercise.

1310A – A Custom Apparatus for Larger Animal Models

CHALLENGE

In 2011 Aurora Scientific was approached by Dr. Christopher Cardozo at the VA Medical Center to assist with researching the mechanisms of muscle atrophy in rats.

1400A – Durable System Helps Researcher Study Thousands of Fibers

CHALLENGE

In 2004, Dr. Hans Degens was studying changes in skeletal muscle function and morphology. Dr. Degens was looking to use permeabilized fibers as his test samples as they represent a pure system for studying cross-bridge mechanics without bias and artifacts.

300C Series Custom Modification Facilitates Genetic Therapy Research for Rare Myopathies

CHALLENGE

A group of researchers in North Carolina had several colonies of specially bred dogs as a model for muscular dystrophy and other rare myopathic disorders.

300C – Dual-Mode Muscle Lever Enables Myonecrosis Research in Injured Muscle

CHALLENGE

Dr. Cliff Bayer has been studying myonecrosis induced by Group A streptococci (GAS) bacteria at V.A. Medical Center in Boise Idaho. Interestingly, this necrotizing infection develops in sites of muscle injury and is thought to be exacerbated by anti-inflammatory drugs (NSAIDs).

400A – Studying cancer cachexia in mouse models

CHALLENGE

In 2011 Dr. Theresa Guise and her colleague Dr. Andrew Marks approached Aurora Scientific seeking help in functionally characterizing muscle from their mouse tumor model. They were looking to assess the progression of muscle loss and weakness in these mice and investigate potential therapies.

900B – Sarcomere Length in Zebrafish Larvae

CHALLENGE

In 2011 Dr. Dennis Claflin approached us to try out our 900B Video Sarcomere Length system. Dr. Claflin was a long time user of Aurora Scientific equipment and an expert in single fiber measurements. He had been using a simple laser diffraction method to quantify SL in his permeabilized fibers, however, this method was not compatible with another one of his chambers.

1200A

1300A

1500A