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Molecular Biology & Pharmacology

The study of animal models is one of the foundational pillars of molecular biology research. Aurora Scientific understands that your animal model is unique, and that characterizing its molecular phenotype can be challenging. It is important that the mechanism of drug action be understood in order to comprehend complex tissue responses. We have the solutions to study gross whole body physiology or the function of specific muscles to make characterizing the response of your animal model to pharmaceuticals both precise and efficient.

Understanding Muscle Biochemistry and the Response to Pharmaceuticals

knockout mouse function, signaling and transduction pathways, muscle regulatory proteins, stretch-activated channels

1500A: Isolated Muscle System - Microscope Mountable

1500A: Isolated Muscle System - Microscope Mountable

Measure complete mechanical properties of small samples with a turnkey system for intact muscle and physiological tissues.
1400A: Permeabilized Fiber System - Microscope Mountable

1400A: Permeabilized Fiber System - Microscope Mountable

Simplify your most demanding permeabilized fiber experiments with a revolutionary automatic indexing test system.
1200A: Isolated Muscle System - Mouse

1200A: Isolated Muscle System - Mouse

The industry leading, easy-to-use test system for measuring the mechanical properties of isolated muscle, bundles and strips.
1300A: 3-in-1 Whole Animal System - Mouse

1300A: 3-in-1 Whole Animal System - Mouse

A flexible test system that delivers accurate measurement of rodent muscle properties in-situ, in-vivo and in-vitro.

Dr. Fabio Minozzo – McGill University

I’ve worked with Aurora Scientific for more than five years now. Their systems, including software and hardware, are solid and reliable. But, above all, their personnel are what makes ASI a unique company: their people are not only experts in their fields but they are also friendly and extremely helpful. Their support works fast and they never let you down. Considering all together, I strongly recommend ASI.

1200A – Easy to Use System Is an Invaluable Tool for Lab

CHALLENGE

In 2013 Aurora Scientific was approached by Dr. Espen Spangenburg at the University of Maryland about our 1200A test system for working with isolated EDL and soleus muscle taken from mice.

1300A – 3-in-1 Test System Helps Major Pharmaceutical Companies Dramatically Improve Throughput

CHALLENGE

Several large Fortune 500 pharmaceutical companies sought a way to quickly screen large groups of mice that had been treated with new experimental compounds/therapies.

1305A – Footplate Configuration for Rats Invaluable to the Study of Muscle Damage

CHALLENGE

In 2012, Marius Locke at the University of Toronto had been studying skeletal muscle damage and the role that heat shock proteins (HSPs) play in protecting the muscle from stress-induced damage, such as exercise.

1400A – Durable System Helps Researcher Study Thousands of Fibers

CHALLENGE

In 2004, Dr. Hans Degens was studying changes in skeletal muscle function and morphology. Dr. Degens was looking to use permeabilized fibers as his test samples as they represent a pure system for studying cross-bridge mechanics without bias and artifacts.

300C – Dual-Mode Muscle Lever Enables Myonecrosis Research in Injured Muscle

CHALLENGE

Dr. Cliff Bayer has been studying myonecrosis induced by Group A streptococci (GAS) bacteria at V.A. Medical Center in Boise Idaho. Interestingly, this necrotizing infection develops in sites of muscle injury and is thought to be exacerbated by anti-inflammatory drugs (NSAIDs).

801C – Ability to Assess Oxygen Consumption/Customization

CHALLENGE

In 2008 Dr. Carter Ralphe at the University of Wisconsin was attempting to measure force and contractility in his tissue constructs in an oxygen sealed environment.

1200A

1300A

1400A

1500A